Polysaccharide Based Hydrogels for Biomedical Applications
Polysaccharide based hydrogels for their physico-chemical and biological properties can be used as scaffolds for soft tissue regneration and as vehicles for drug controlled release. For both these applications, Hyaluronan shows optimal characteristics even though its quick enzymatic degradability makes this natural polysaccharide unsuitable for applications which require prolonged presence in the human organism.
For this reason, new semisynthetic polysaccharides based on carboxymethylcellulose alginate and guar were developed and tested as cartilage substitutes, nucleus pulposus substitutes and as a vehicle for biologically active substances directed towards bone tissue regeneration.
KeywordsIntervertebral Disc Nucleus Pulposus Nucleus Pulposus Cell Alginate Hydrogel Amidation Reaction
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