Hydrogels pp 25-41 | Cite as

Polysaccharide Based Hydrogels for Biomedical Applications

  • Gemma Leone
  • Rolando Barbucci


Polysaccharide based hydrogels for their physico-chemical and biological properties can be used as scaffolds for soft tissue regneration and as vehicles for drug controlled release. For both these applications, Hyaluronan shows optimal characteristics even though its quick enzymatic degradability makes this natural polysaccharide unsuitable for applications which require prolonged presence in the human organism.

For this reason, new semisynthetic polysaccharides based on carboxymethylcellulose alginate and guar were developed and tested as cartilage substitutes, nucleus pulposus substitutes and as a vehicle for biologically active substances directed towards bone tissue regeneration.


Intervertebral Disc Nucleus Pulposus Nucleus Pulposus Cell Alginate Hydrogel Amidation Reaction 


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Copyright information

© Springer-Verlag Italia, Milan 2009

Authors and Affiliations

  • Gemma Leone
    • 1
  • Rolando Barbucci
    • 1
  1. 1.Department of Chemical and Biosystem Sciences and Technologies and Interuniversity Research Center for Advanced Medical Systems (C.R.I.S.M.A.)University of SienaItaly

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