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On-Off Switching Properties of ultra thin Intelligent Temperature-Responsive Polymer Modified Surface

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Book cover Hydrogels

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Abstract

Intelligent temperature-responsive polymers are currently utilized in a variety of fields within engineering and medicine. Particularly, special attention has been paid to the temperature-responsive polymer, poly(N-isopropylacrylamide) (PIPAAm). We have investigated properties of PIAAm grafted surfaces and applied the surfaces to novel chromatography matrix and novel cell culture surfaces. In this chapter, we describe the features of PIPAAm grafted surfaces in response to external temperature stimuli. We discuss the features in terms of the degree of the mobility of the grafted polymer chains as well as hydration and dehydration of the chains by temperature change. For culturing cells on PIPAAm grafted surfaces, nanometer-thickness of the grafted PIPAAm layer plays a crucial role in cell adhesion/attachment behavior. Furthermore, we introduce a new concept for tissue engineering, utilizing temperature-responsive polymer grafted tissue culture dishes, and summarize the development of advanced temperature-responsive cell culture surfaces.

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Authors and Affiliations

  1. Institute of Advanced Biomedical Engineering and Science Tokyo, Women’s Medical University, TWIns, Tokyo, Japan

    Yoshikatsu Akiyama & Teruo Okano

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  1. Yoshikatsu Akiyama
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  2. Teruo Okano
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© 2009 Springer-Verlag Italia, Milan

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Akiyama, Y., Okano, T. (2009). On-Off Switching Properties of ultra thin Intelligent Temperature-Responsive Polymer Modified Surface. In: Hydrogels. Springer, Milano. https://doi.org/10.1007/978-88-470-1104-5_14

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