Hydrogels pp 179-197 | Cite as

On-Off Switching Properties of ultra thin Intelligent Temperature-Responsive Polymer Modified Surface

  • Yoshikatsu Akiyama
  • Teruo Okano


Intelligent temperature-responsive polymers are currently utilized in a variety of fields within engineering and medicine. Particularly, special attention has been paid to the temperature-responsive polymer, poly(N-isopropylacrylamide) (PIPAAm). We have investigated properties of PIAAm grafted surfaces and applied the surfaces to novel chromatography matrix and novel cell culture surfaces. In this chapter, we describe the features of PIPAAm grafted surfaces in response to external temperature stimuli. We discuss the features in terms of the degree of the mobility of the grafted polymer chains as well as hydration and dehydration of the chains by temperature change. For culturing cells on PIPAAm grafted surfaces, nanometer-thickness of the grafted PIPAAm layer plays a crucial role in cell adhesion/attachment behavior. Furthermore, we introduce a new concept for tissue engineering, utilizing temperature-responsive polymer grafted tissue culture dishes, and summarize the development of advanced temperature-responsive cell culture surfaces.


Lower Critical Solution Temperature Cell Sheet Biomed Mater Silica Bead Contact Angle Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia, Milan 2009

Authors and Affiliations

  • Yoshikatsu Akiyama
    • 1
  • Teruo Okano
    • 1
  1. 1.Institute of Advanced Biomedical Engineering and Science TokyoWomen’s Medical University, TWInsTokyoJapan

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