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Novel pH/Temperature-Sensitive Hydrogels Based on Poly(β-Amino Ester) for Controlled Protein Delivery

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Hydrogels

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Abstract

The concept of this research was to use poly(β-amino ester) (PAE) as a bi-functional group for synthesis of the novel stimuli-sensitive injectable hydrogels for controlled drug/protein delivery. Firstly, PAE was used as a pH-sensitive moiety to conjugate with the temperature-sensitive biodegradable triblock copolymer of poly(ethylene glycol)-poly(ε-caprolactone)(PCL-PEG-PCL) or poly(ethylene glycol)-poly(ε-caprolactone-co-D,L-lactide) (PACL-PEG-PCLA). Secondly, the cationic nature of PAE was used as the second function to make ionic complexes with anionic biomolecules loaded onto the hydrogel such as insulin. As a result, the release of the drug/protein from the hydrogel device can be controlled by the degradation of the copolymer.

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Authors and Affiliations

  1. Department of Polymer Science and Engineering, SungKyunKwan University, Suwon, Kyungki, Korea

    Dai Phu Huynh, Chaoliang He & Doo Sung Lee

Authors
  1. Dai Phu Huynh
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  2. Chaoliang He
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  3. Doo Sung Lee
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© 2009 Springer-Verlag Italia, Milan

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Huynh, D.P., He, C., Lee, D.S. (2009). Novel pH/Temperature-Sensitive Hydrogels Based on Poly(β-Amino Ester) for Controlled Protein Delivery. In: Hydrogels. Springer, Milano. https://doi.org/10.1007/978-88-470-1104-5_13

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