Novel pH/Temperature-Sensitive Hydrogels Based on Poly(β-Amino Ester) for Controlled Protein Delivery
The concept of this research was to use poly(β-amino ester) (PAE) as a bi-functional group for synthesis of the novel stimuli-sensitive injectable hydrogels for controlled drug/protein delivery. Firstly, PAE was used as a pH-sensitive moiety to conjugate with the temperature-sensitive biodegradable triblock copolymer of poly(ethylene glycol)-poly(ε-caprolactone)(PCL-PEG-PCL) or poly(ethylene glycol)-poly(ε-caprolactone-co-D,L-lactide) (PACL-PEG-PCLA). Secondly, the cationic nature of PAE was used as the second function to make ionic complexes with anionic biomolecules loaded onto the hydrogel such as insulin. As a result, the release of the drug/protein from the hydrogel device can be controlled by the degradation of the copolymer.
KeywordsBlock Copolymer Insulin Release Triblock Copolymer Copolymer Solution Phosphate Buffer Saline Buffer
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