Multifocal and Multicentric Tumors

  • Carlo de Werra
  • Ivana Donzelli
  • Mario Perone
  • Rosa Di Micco
  • Gianclaudio Orabona
Part of the Updates in Surgery book series (UPDATESSURG)


Multifocal tumors are not multiple tumors; they originate from a unique cellular clone and grow multifocally in a single organ (liver, kidney, thyroid, etc.). These tumors are not included as multiple primary malignancies (MPM), but they can represent a single event of this syndrome. Multicentric tumors are also different because they develop simultaneously in more than one organ (e.g, breast, mono- or bilaterally in the kidney), but without a clonal relationship with respect to their carcinogenesis. The differential diagnosis is often very difficult. Examples of multifocality are mammary carcinoma, renal cell carcinoma, hepatocellular carcinoma, and esophageal adenocarcinoma.


Papillary Thyroid Carcinoma Multifocal Tumor Multicentric Tumor Multiple Primary Malignancy Multifocal Papillary Thyroid Carcinoma 


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Copyright information

© Springer-Verlag Italia 2009

Authors and Affiliations

  • Carlo de Werra
    • 1
  • Ivana Donzelli
    • 1
  • Mario Perone
    • 1
  • Rosa Di Micco
    • 1
  • Gianclaudio Orabona
    • 1
  1. 1.General, Oncological, Geriatrical and Advanced Technology DepartmentFederico II UniversityNaplesItaly

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