Skip to main content
SpringerLink
Log in

Multiple Primary Malignancies and Human Papilloma Virus Infections

  • Chapter
Multiple Primary Malignancies

Part of the book series: Updates in Surgery ((UPDATESSURG))

  • 655 Accesses

Abstract

Patients may develop multiple primary malignancies (MPM) due to the occurrence of many known predisposing factors (i.e. genetic background, environmental factors, hormonal unbalance, and acquired immunosuppression); however, in most cases, no obvious cause of has been found [1–3]. During the last few decades, accumulating evidence has pointed to the involvement of human papillomavirus (HPV) in the development of several neoplastic and preneoplastic lesions of anatomic sites beyond the uterine cervix. In particular, HPV has been associated with squamous cell carcinomas and related precursors in the oral cavity, esophagus, skin, larynx, conjunctiva, paranasal sinuses and bronchus, but even in non-Malpighian-derived tumors, such as urinary bladder carcinoma. At least for a subset of these cases, it has been suggested that exposure to HPV can precede the appearance of cancer by 10 or more years [4, 5]; nonetheless, the true prevalence of HPV DNA in pre-cancerous lesions remains uncertain.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Yamamoto S, Yoshimura K, Ri S et al (2006) The risk of multiple primary malignancies with colorectal carcinoma. Dis Colon Rectum 49:S30–36

    Article  PubMed  Google Scholar 

  2. Colangelo LA, Gapstur SM, Gann PH et al (2004) Cigarette smoking and colorectal carcinoma mortality in a cohort with long-term follow-up. Cancer 100:288–293

    Article  PubMed  Google Scholar 

  3. Otani T, Iwasaki M, Yamamoto S et al (2003) Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and female: Japan Public Health Center-based prospective study. Cancer Epidemiol Biomarkers Prev 12:1492–1500

    PubMed  CAS  Google Scholar 

  4. Syrjänen S (2007) Human papillomaviruses in head and neck carcinomas. N Engl J Med 356: 1993–1995

    Article  PubMed  Google Scholar 

  5. Mork J, Lie AK, Glattre E et al (2001) Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 344:1125–1131

    Article  PubMed  CAS  Google Scholar 

  6. Bosch FX, Lorincz A, Munoz N (2002) The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 55:244–265

    PubMed  CAS  Google Scholar 

  7. Wright TC, Schiffman M, Solomon D et al (2004) Interim guidance for the use of human papillomavirus DNA testing as an adjunct to cervical cytology for screening. Obstet Gynecol 103:304–308

    PubMed  Google Scholar 

  8. Schiffman M, Kjaer SK (2003) Natural history of anogenital human papillomavirus infection and neoplasia. J Natl Cancer Inst Monogr 31:14–19

    PubMed  Google Scholar 

  9. Castellsague X, Munoz N (2003) Cofactors in human papillomavirus carcinogenesis-role of parity, oral contraceptives, and tobacco smoking. J Natl Cancer Inst Monogr 31:20–28

    PubMed  Google Scholar 

  10. Palefsky JM, Holly EA (2003) Immunosuppression and co-infection with HIV. J Natl Cancer Inst Monogr 31:41–46

    PubMed  Google Scholar 

  11. Kreimer AR, Clifford GM, Boyle P et al (2005) Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev 14:467–475

    Article  PubMed  CAS  Google Scholar 

  12. Polo SE, Yheocharis SE, Klijaieko J et al (2004) CAF-1, a marker of clinical value to distinguish quiescent from proliferative cells. Cancer Res 64:2371–2381

    Article  PubMed  CAS  Google Scholar 

  13. Staibano S, Mignogna C, Lo Muzio L et al (2007) Chromatin assembly factor-1 (CAF-1) mediated regulation of cells proliferation and DNA repair: a link with the biological behavior of squamous cell carcinoma of the tongue. Histopathology 50:911–919

    Article  PubMed  CAS  Google Scholar 

  14. Staibano S, Mascolo M, Mancini FP et al (2008) Chromatin Assembly Factor-1 (CAF-1) “a prostate cancer progression marker?” (In press)

    Google Scholar 

  15. Staibano S, Mascolo M, Scalvenzi M (2008) Detection of biological profile of cutaneous malignant melanoma by CAF-1 proteins expression. (In press)

    Google Scholar 

  16. Staibano S, Mascolo M, Nugnes L et al (2008) CAF-1 and chromatin states in the cervical cancer: is there a correlation?” (In press)

    Google Scholar 

  17. Lo Muzio L, Staibano S, Pannone G et al (2001) Expression of the apoptosis inhibitor survivin in aggressive squamous cell carcinoma. Exp Mol Pathol 70:249–254

    Article  PubMed  CAS  Google Scholar 

  18. Li HP, Leu YW, Chang YS (2005) Epigenetic changes in virus-associated human cancers. Cell Research 15:262–271

    Article  PubMed  CAS  Google Scholar 

  19. Matsukura T, Sugase M (2001) Relationship between 80 Human papillomavirus genotypes and different grades of cervical intraepithelial neoplasia: Association and causality. Virology 283:139–147

    Article  PubMed  CAS  Google Scholar 

  20. Woodman CB, Collins SI, Young LS (2007) The natural history of cervical HPV infection: unresolved issues Nat Rev Cancer 7:11–22

    Article  PubMed  CAS  Google Scholar 

  21. Sedjo RL, Inserra P, Abrahamsen M et al (2002) Human papillomavirus persistence and nutrients involved in the methylation pathway among a cohort of young women. Cancer Epidemiol Biomarkers Prev 11:353–359

    PubMed  CAS  Google Scholar 

  22. Kim K, Garner-Hamrick PA, Fisher C et al (2003) Methylation patterns of papillomavirus DNA, its influence on E2 function, and implications in viral infection. J Virol 77:12450–12459

    Article  PubMed  CAS  Google Scholar 

  23. Badal S, Badal V, Calleya-Macias IE et al (2004) The human papillomavirus-18 genome is efficiently targeted by cellular DNA methylation. Virology 324:483–492

    Article  PubMed  CAS  Google Scholar 

  24. Turan T, Kalantoni M, Calleya-Macias IE et al (2006) Methylation of the human papillomavirus-18 L1 gene: a biomarker of neoplastic progression? Virology 349:175–183

    Article  PubMed  CAS  Google Scholar 

  25. Badal V, Chuang LS, Tan EH et al (2004) CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression. J Virol 77:6227–6234

    Article  Google Scholar 

  26. Kang GH, Lee S, Kim WH et al (2002) Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol 160:787–794

    PubMed  CAS  Google Scholar 

  27. Vo QN, Geradts J, Gulley ML et al (2002) Epstein-Barr virus in gastric adenocarcinomas: association with ethnicity and CDKN2A promoter methylation. J Clin Pathol 55:669–675

    Article  PubMed  CAS  Google Scholar 

  28. Yang B, Guo M, Herman JG et al (2003) Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol 163:1101–1107

    PubMed  CAS  Google Scholar 

  29. Li X, Hui AM, Sun L et al (2004) P16INK4A hypermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma. Clin Cancer Res 10:7484–7489

    Article  PubMed  CAS  Google Scholar 

  30. Kim NR, Lin Z, Kim KR et al (2005) Epstein-Barr virus and p16INK4A methylation in squamous cell carcinoma and precancerous lesions of the cervix uteri. J Korean Med Sci 20:636–642

    Article  PubMed  Google Scholar 

  31. Suzuki M, Toyooka S, Shivapurkar N et al (2005) Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infection. Oncogene 10:1302–1308

    Article  CAS  Google Scholar 

  32. Gasco M, Crook T (2003) The p53 network in head and neck cancer. Oral Oncol 39:222–231

    Article  PubMed  CAS  Google Scholar 

  33. Dong SM, Sun DI, Benoit NE et al (2003) Epigenetic inactivation of RASSF1A in head and neck cancer. Clin Cancer Res 9:3635–3640

    PubMed  CAS  Google Scholar 

  34. Torland EC, Myers SL, Persing DH et al (2000) Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites. Cancer Res 60:5916–5921

    Google Scholar 

  35. Thorland EC, Myers SL, Gostout BS et al (2003) Common fragile sites are preferential targets for HPV16 integrations in cervical tumors. Oncogene 22:1225–1237

    Article  PubMed  CAS  Google Scholar 

  36. Marsit CJ, McClean MD, Furniss CS et al (2006) Epigenetic inactivation of the SFRP genes is associated with drinking, smoking and HPV in head and neck squamous cell carcinoma. IntJ Cancer 119:1761–1766

    Article  CAS  Google Scholar 

  37. Chan AO, Peng JZ, Lam SK et al (2006) Eradication of Helicobacter pylori infection reverses E-cadherin promoter hypermethylation Gut 55:463–468

    Article  PubMed  CAS  Google Scholar 

  38. Esteller M (2006) Epigenetics provides a new generation of oncogenes and tumour-suppressor genes. Br J Cancer 94:179–183

    Article  PubMed  CAS  Google Scholar 

  39. Monk BJ, Wiley DJ (2004) Human papillomavirus infections: truth or consequences. Cancer 100:225–227

    Article  PubMed  Google Scholar 

  40. Woodman CB Collins S Winter H et al (2001) Natural history of cervical human Papillomavirus infection in young women: a longitudinal cohort study. Lancet 357:1831–1836

    Article  PubMed  CAS  Google Scholar 

  41. Syrjänen S (2004) HPV infections and tonsillar carcinoma. J Clin Pathol 57:449–455

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biomorfological and Functional Sciences, Unit of Pathology, Federico II University, Naples, Italy

    Stefania Staibano, Massimo Mascolo, Lorenzo Lo Muzio, Gennaro Ilardi, Loredana Nugnes & Gaetano De Rosa

  2. Surgical, Anesthesiology-rianimative and Emergency Sciences Department, Federico II University, Naples, Italy

    Concetta Dodaro & Andrea Renda

Authors
  1. Stefania Staibano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Massimo Mascolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lorenzo Lo Muzio
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gennaro Ilardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Loredana Nugnes
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Concetta Dodaro
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Andrea Renda
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Gaetano De Rosa
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Italia

About this chapter

Cite this chapter

Staibano, S. et al. (2009). Multiple Primary Malignancies and Human Papilloma Virus Infections. In: Multiple Primary Malignancies. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-1095-6_7

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-1095-6_7

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1094-9

  • Online ISBN: 978-88-470-1095-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation