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The Cancer Spectrum Related to Hereditary and Familial Breast and Ovarian Cancers

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Book cover Multiple Primary Malignancies

Part of the book series: Updates in Surgery ((UPDATESSURG))

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Abstract

Multiple factors are associated with an increased risk of developing breast cancer, including age, family history, exposure to reproductive hormones, dietary factors, benign breast diseases, and environmental factors. Recently, increasing interest has been devoted to the interaction between environmental and genetic factors. Family history has been recognized as an important risk factor for developing breast cancer. Individuals with a first-degree family member affected with breast cancer have a relative risk of 2.1 (95% CI = 2.0–2.2). Moreover, risk varies with the age at which the affected relative was diagnosed, the number of affected and unaffected family members and, finally, the closeness of the relationship.

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Authors and Affiliations

  1. Unit of Screening and Follow-up for Hereditary and Familial Cancer, Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy

    Matilde Pensabene, Rosaria Gesuita, Ida Capuano, Caterina Condello, Ilaria Spagnoletti, Eleonora De Maio, Stefano Pepe & Alma Contegiacomo

  2. Centro di Epidemiologia, Biostatistica e Informatica Medica, Università Politecnica delle Marche, Ancona, Italy

    Flavia Carle

Authors
  1. Matilde Pensabene
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  2. Rosaria Gesuita
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  3. Ida Capuano
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  4. Caterina Condello
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  5. Ilaria Spagnoletti
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  6. Eleonora De Maio
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  7. Flavia Carle
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  8. Stefano Pepe
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  9. Alma Contegiacomo
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© 2009 Springer-Verlag Italia

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Pensabene, M. et al. (2009). The Cancer Spectrum Related to Hereditary and Familial Breast and Ovarian Cancers. In: Multiple Primary Malignancies. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-1095-6_10

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  • DOI: https://doi.org/10.1007/978-88-470-1095-6_10

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1094-9

  • Online ISBN: 978-88-470-1095-6

  • eBook Packages: MedicineMedicine (R0)

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