Complications After Pancreatic Surgery

  • F. Francesco di Mola
  • Giuseppe Mascetta
  • Antonio De Bonis
  • Pierluigi di Sebastiano
Part of the Updates in Surgery book series (UPDATESSURG)


Pancreatic cancer is the fourth-leading cause of death from malignant disease; each year about 33,000 individuals in the United States are diagnosed with this condition and more than 60,000 in Europe [1]. It is a devastating disease with a very poor prognosis and has a death rate roughly equal to its incidence rate. Contributing to the high death rate is the often late diagnosis at a stage when the tumor has already metastasized, the possibility of a curative resection is greatly reduced, and responsiveness to conventional oncological treatment options is poor. Although chemotherapy has improved prognosis in many malignancies, its impact on pancreatic cancer is limited. The same is true for intraoperative or external radiotherapy, antihormonal treatment, and immunotherapy. Due to the lack of effective adjuvant treatment protocols, median survival time following diagnosis of nonresectable tumors is only about 4–6 months. For cancers without distant metastases, resectability rates have increased steadily during the past several decades, due in part to improved diagnostic techniques and lower postoperative mortality and morbidity at centers experienced in pancreatic surgery and having a high case load (>40 procedures/yearxxx]. However, long-term survival after resection continues to be low. Recent studies indicate that the 5-year survival rate following resection for pancreatic cancer is only around 10%, with a range between 0.4 and 33% [2].


Pancreatic Cancer Chronic Pancreatitis Gastric Emptying Pancreatic Fistula Pancreatic Resection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia 2009

Authors and Affiliations

  • F. Francesco di Mola
    • 1
  • Giuseppe Mascetta
    • 1
  • Antonio De Bonis
    • 1
  • Pierluigi di Sebastiano
    • 1
  1. 1.Department of General Surgery, Abdominal Surgery UnitCasa Sollievo della Sofferenza, IRCCSSan Giovanni RotondoItaly

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