Abstract
Surgical resection is the most important aspect of therapy for pancreatic carcinoma. However, surgery is increasingly considered as a therapeutic option to be combined with other treatments such as chemotherapy and radiotherapy. This is especially true for locally advanced tumors, where surgical treatment alone does not typically result in a satisfactory rate of overall survival. For pancreatic carcinoma, as for other solid tumors, the therapeutic strategy depends on the stage of the disease, and accurate staging is mandatory before starting treatment. In the last 20 years, this strategy has promoted the development of more accurate and sophisticated staging techniques; historically, exploratory laparotomies accounted for up to 50% of the patients considered to be resectable at preoperative staging [1–4], and modern multimodal treatments are diversified regardless of whether the tumor is resectable, locally advanced, or metastatic [5, 6].
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References
Yeo CJ, Cameron JL (1999) Improving results of pancreaticoduodenectomy for pancreatic cancer. World J Surg 23:907–912
Parker SL, Tong T, Bolden S et al (1996) Cancer statistics, 1996. CA Cancer J Clin 46:5–27
Kalra MK, Maher MM, Mueller PR et al (2003) State-of-the-art imaging of pancreatic neoplasms. Br J Radiol 76:857–865
Soriano A, Castells A, Ayuso C et al (2004) Preoperative staging and tumor resectability assessment of pancreatic cancer: prospective study comparing endoscopic ultrasonography, helical computed tomography, magnetic resonance imaging, and angiography. Am J Gastroenterol 99:492–501
Liu RC, Traverso LW (2005) Diagnostic laparoscopy improves staging of pancreatic cancer deemed locally unresectable by computed tomography. Surg Endosc 19:638–642
Shoup M, Winston C, Brennan MF et al (2004) Is there a role for staging laparoscopy in patients with locally advanced, unresectable pancreatic adenocarcinoma? J Gastrointest Surg 8:1068–1071
Minnard EA, Conlon KC, Hoos A et al (1998) Laparoscopic ultrasound enhances standard laparoscopy in the staging of pancreatic cancer. Ann Surg 228:182–187
Merchant NB, Conlon KC (1998) Laparoscopic evaluation in pancreatic cancer. Semin Surg Oncol 15:155–165
Cuschieri A, Hall AW, Clark J (1978) Value of laparoscopy in the diagnosis and management of pancreatic carcinoma. Gut 19:672–677
Nieveen van Dijkum EJ, Romijn MG, Terwee CB et al (2003) Laparoscopic staging and subsequent palliation in patients with peripancreatic carcinoma. Ann Surg 237:66–73
Katz MH, Hwang R, Fleming JB et al (2008) Tumor-node-metastasis staging of pancreatic adenocarcinoma. CA Cancer J Clin 58:111–125
National Comprehensive Cancer Network (2008) NCCN practice guidelines for pancreatic cancer. Available at: http://www.nccn.org. Accessed May 2008
Varadhachary GR, Tamm EP, Abbruzzese JL et al (2006) Borderline resectable pancreatic cancer: definitions, management, and role of preoperative therapy. Ann Surg Oncol 13:1035–1046
Lawson TL (1978) Sensitivity of pancreatic ultrasonography in the detection of pancreatic disease. Radiology 128:733–736
Taylor KJW, Buchin PJ, Viscomi GN et al (1981) Ultrasonographic scanning of the pancreas. Radiology 138:211–213
Pasanen PA, Partanen KP, Pikkarainen PH et al (1993) A comparison of ultrasound, computed tomography and endoscopic retrograde cholangiopancreatography in the differential diagnosis of benign and malignant jaundice and cholestasis. Eur J Surg 159:23–29
Karlson BM, Ekbom A, Lindgren PG et al (1999) Abdominal US for diagnosis of pancreatic tumor: prospective cohort analysis. Radiology 213:107–111
Michl P, Pauls S, Gress TM (2006) Evidence-based diagnosis and staging of pancreatic cancer. Best Pract Res Clin Gastroenterol 20:227–251
Clarke DL, Thomson SR, Madiba TE et al (2003) Preoperative imaging of pancreatic cancer: a management-oriented approach. J Am Coll Surg 196:119–129
Tomiyama T, Ueno N, Tano S et al (1996) Assessment of arterial invasion in pancreatic cancer using color Doppler ultrasonography. Am J Gastroenterol 91:1410–1416
Morrin MM, Kruskal JB, Raptopoulos V et al (2001) State-of-the-art ultrasonography is as accurate as helical computed tomography and computed tomographic angiography for detecting unresectable periampullary cancer. J Ultrasound Med 20:481–490
Rosch T, Lightdale CJ, Botet JF et al (1992) Localization of pancreatic endocrine tumors by endoscopic ultrasonography. N Engl J Med 326:1721–1726
Yasuda K, Mukai H, Nakajima M (1995) Endoscopic ultrasonography diagnosis of pancreatic cancer. Gastrointest Endosc Clin N Am 5:699–712
Hunt GC, Faigel DO (2002) Assessment of EUS for diagnosing, staging, and determining resectability of pancreatic cancer: a review. Gastrointest Endosc 55:232–237
Kulig J, Popiela T, Zajac A et al (2005) The value of imaging techniques in the staging of pancreatic cancer. Surg Endosc 19:361–365
Buscail L, Pages P, Berthelemy P et al (1999) Role of EUS in the management of pancreatic and ampullary carcinoma: a prospective study assessing resectability and prognosis. Gastrointest Endosc 50:34–40
Ahmad NA, Lewis JD, Ginsberg GG et al (2000) EUS in preoperative staging of pancreatic cancer. Gastrointest Endosc 52:463–468
Akahoshi K, Chijiiwa Y, Nakano I et al (1998) Diagnosis and staging of pancreatic cancer by endoscopic ultrasound. Br J Radiol 71:492–496
Rosch T, Braig C, Gain T et al (1992) Staging of pancreatic and ampullary carcinoma by endoscopic ultrasonography. Comparison with conventional sonography, computed tomography, and angiography. Gastroenterology 102:188–199
Muller MF, Meyenberger C, Bertschinger P et al (1994) Pancreatic tumors: evaluation with endoscopic US, CT and MR imaging. Radiology 190:745–751
Midwinter MJ, Beveridge CJ, Wilsdon JB et al (1999) Correlation between spiral comuted tomography, endoscopic ultrasonography and findings at operation in pancreatic and ampullary tumours. Br J Surg 86:189–193
Brugge WR, Lee MJ, Kelsey PB et al (1996) The use of EUS to diagnose malignant portal venous system invasion by pancreatic cancer. Gastrointest Endosc 43:561–567
Aslanian H, Salem R, Lee J et al (2005) EUS diagnosis of vascular invasion in pancreatic cancer: surgical and histologic correlates. Am J Gastroenterol 100:1381–1385
Sahani DV, Shah ZK, Catalano OA et al (2008) Radiology of pancreatic adenocarcinoma: current status of imaging. J Gastroenterol Hepatol 23:23–33
Rösch T, Lorenz R, Braig C et al (1991) Endoscopic ultrasound in pancreatic tumor diagnosis. Gastrointest Endosc 37:347–352
Grimm H, Binmoeller KF, Soehendra N (1992) Endosonography-guided drainage of a pancreatic pseudocyst. Gastrointest Endosc 38:170–171
Erickson RA (2004) EUS-guided FNA. Gastrointest Endosc 60:267–279
Wiersema MJ, Vilmann P, Giovannini M et al (1997) Endosonography-guided fine-needle aspiration biopsy: diagnostic accuracy and complication assessment. Gastroenterology 112:1087–1095
Dupuy DE, Costello P, Ecker CP (1992) Spiral CT of the pancreas. Radiology 183:815–818
Taoka H, Hauptmann E, Traverso LW et al (1999) How accurate is helical computed tomography for clinical staging of pancreatic cancer? Am J Surg 177:428–432
Bluemke DA, Cameron JL, Hruban RH et al (1995) Potentially resectable pancreatic adenocarcinoma: spiral CT assessment with surgical and pathologic correlation. Radiology 197:381–385
Phoa SSKS, Reeders JWAJ, Rauws EAJ (1999) Spiral computed tomography for preoperative staging of potentially resectable carcinoma of the pancreatic head. Br J Surg 86:789–794
Vendenthan S, LU DSK, Reber HA et al (1998) Small peripancreatic veins; improved assessment in pancreatic cancer patients using thin section pancreatic phase helical CT. AJR Am J Roentgenol 170:377–383
Horton KM, Fishman EK (2000) 3D CT angiography of the celiac and superior mesenteric arteries with multidetector CT data sets: preliminary observations. Abdom Imaging 25:523–525
Fishman EK, Horton KM, Urban BA (2000) Multidetector CT angiography in the evaluation of pancreatic carcinoma: preliminary observations. J Comput Assist Tomogr 24:849–853
Bronstein YL, Loyer EM, Kaur H et al (2004) Detection of small pancreatic tumors with multiphasic helical CT. Am J Roentgenol 182:619–623
Li H, Zeng MS, Zhou KR et al (2005) Pancreatic adenocarcinoma: the different CT criteria for peripancreatic major arterial and venous invasion. J Comput Assist Tomogr 29:170–175
Prokesch RW, Chow LC, Beaulieu CF et al (2002) Local staging of pancreatic carcinoma with multi-detector row CT: use of curved planar reformations — initial experience. Radiology 225:759–765
Furukawa H, Uesaka K, Boku N (2008) Treatment decision making in pancreatic adenocarcinoma: multidisciplinary team discussion with multidetector-row computed tomography. Arch Surg 143:275–280
Roche CJ, Hughes ML, Garvey CJ et al (2003) CT and pathologic assessment of prospective nodal staging in patients with ductal adenocarcinoma of the head of the pancreas. AJR Am J Roentgenol 180:475–480
Pisters PW, Lee JE, Vauthey JN et al (2001) Laparoscopy in the staging of pancreatic cancer. Br J Surg 88:325–337
Megibow AJ, Zhou XH, Rotterdam H et al (1995) Pancreatic adenocarcinoma: CT versus MR imaging in the evaluation of resectability: report of the radiology diagnostic oncology group. Radiology 195:327–332
Ichikawa T, Haradome H, Hachiya J et al (1997) Pancreatic ductal adenocarcinoma: preoperative assessment with helical CT versus dynamic MR imaging. Radiology 202:655–662
Semelka RC, Ascher SM (1993) MR imaging of the pancreas. Radiology 188:593–602
Saisho H, Yamaguchi T (2004) Diagnostic imaging for pancreatic cancer: computed tomography, magnetic resonance imaging, and positron emission tomography. Pancreas 28:273–278
Pamuklar E, Semelka RC (2005) MR imaging of the pancreas. Magn Reson Imaging Clin N Am 13:313–330
Semelka RC, Shouenut JP, Kroeker MA (1993) Chronic pancreatitis: MRI features before and after administration of gadopentate dimeglumine. J Magn Reson Imaging 3:79–82
Wallner BK, Schumaker KA, Weidenmaier W et al (1991) Dilated biliary tract: evaluation with MR cholangiography with a T2-weighted contrast-enhanced fast sequence. Radiology 181:805–808
Mehta SN, Reinhold C, Barkun AN (1997) Magnetic resonance cholangiopancreatography. Gastrointest Endosc Clin N Am 7:247–270
Adamek H, Albert J, Breer H et al (2000) Pancreatic cancer detection with MR cholangiopancreatography and endoscopic retrograde cholangiopancreatography: a prospective controlled study. Lancet 356:190–193
Lee MG, Lee HJ, Kim MH et al (1997) Extrahepatic biliary diseases: 3D MR cholangiopancreatography compared with endoscopic retrograde cholangiopancreatography. Radiology 202:663–669
Hirschowitz BI, Curtiss LE, Peters CW et al (1958) Demonstration of a new gastroscope, the “fiberscope”. Gastroenterology 35:50
Siegel JH (1992) Endoscopic retrograde cholangiopancreatography. Technique, diagnosis and therapy. Raven, New York
Niederau C, Grendell JH (1992) Diagnosis of pancreatic carcinoma. Imaging techniques and tumor markers. Pancreas 7:66–86
Aly EA, Johnson CD (2001) Preoperative biliary drainage before resection in obstructive jaundice. Dig Surg 18:84–89
Flamm CR, Mark DH, Aronson N (2002) Evidence-based assessment of ERCP approaches to managing pancreaticobiliary malignancies. Gastrointest Endosc 56(6Suppl):S218–S225
Strasberg SM (2002) ERCP and surgical intervention in pancreatic and biliary malignancies. Gastrointest Endosc 56:S213–S217
Keogan MT, Tyler D, Clark L et al (1998) Diagnosis of pancreatic carcinoma: role of FDG PET. AJR Am J Roentgenol 171:1565–1570
Sendler A, Avril N, Helmberger H et al (2000) Preoperative evaluation of pancreatic masses with positron emission tomography using 18F-fluorodeoxyglucose: diagnostic limitations. World J Surg 24:1121–1129
Rose DM, Delbeke D, Beauchamp RD et al (1999) 18Fluorodeoxyglucose-positron emission tomography in the management of patients with suspected pancreatic cancer. Ann Surg 229:729–737
Friess H, Langhans J, Ebert M et al (1995) Diagnosis of pancreatic cancer by 2[18F]-fluoro-2-deoxy-d-glucose positron emission tomography. Gut 36:771–777
Annovazzi A, Peeters M, Maenhout A et al (2003) 18-Fluorodeoxyglucose positron emission tomography in nonendocrine neoplastic disorders of the gastrointestinal tract. Gastroenterology 125:1235–1245
Diederichs CG, Staib L, Vogel J et al (2000) Values and limitations of 18F-fluorodeoxyglucose-positron-emission tomography with preoperative evaluation of patients with pancreatic masses. Pancreas 20:109–116
Heinrich S, Goerres GW, Schafer M et al (2005) Positron emission tomography/computed tomography influences on the management of resectable pancreatic cancer and its cost-effectiveness. Ann Surg 242:235–243
Bernheim BM (1911) Organoscopy: cystoscopy of the abdominal cavity. Ann Surg 53:764–767
Cuschieri A, Hall AW, Clark J (1978) Value of laparoscopy in the diagnosis and management of pancreatic carcinoma. Gut 19:672–677
Stefanidis D, Grove KD, Schwesinger WH et al (2006) The current role of staging laparoscopy for adenocarcinoma of the pancreas: a review. Ann Oncol 17:189–199
White R, Winston C, Gonen M, D’Angelica et al (2008) Current utility of staging laparoscopy for pancreatic and peripancreatic neoplasms. J Am Coll Surg 206:445–450
Conlon KC, Dougherty E, Klimstra DS et al (1996) The value of minimal access surgery in the staging of patients with potentially resectable peripancreatic malignancy. Ann Surg 223:134–140
Leach SD, Rose JA, Lowy AM et al (1995) Significance of peritoneal cytology in patients with potentially resectable adenocarcinoma of the pancreatic head. Surgery 82:472–478
Merchant NB, Conlon KC, Saigo P et al (1999) Positive peritoneal cytology predicts unresectability of pancreatic adenocarcinoma. J Am Coll Surg 188:421–426
Nakao A, Oshima K, Takeda S et al (1999) Peritoneal washings cytology combined with immunocytochemical staging in pancreatic cancer. Hepatogastroenterology 46:2974–2977
Yachida S, Fukushima N, Sakamoto M et al (2002) Implications of peritoneal washing cytology in patients with potentially resectable pancreatic cancer. Br J Surg 89:573–578
Yamada S, Takeda S, Fujii T et al (2007) Clinical implications of peritoneal cytology in potentially resectable pancreatic cancer: positive peritoneal cytology may not confer an adverse prognosis. Ann Surg 246:254–258
Berber E, Garland AM, Engle KL et al (2004) Laparoscopic ultrasonography and biopsy of hepatic tumor in 310 patients. Am J Surg 187:213–218
Charukhchyan SA, Lucas GW (1998) Laparoscopy and lesser sac endoscopy in gastric carcinoma operability assessment. Am Surg 64:160–164
Jaeck D, Boudjema K, Bachellier P et al (1998) Exeresi pancreatiche cefaliche: duodenocefalo-pancreasectomie (DCP). In: Encyclopédie médico chirurgicale: Tecniche chirurgiche — Addominale. Elsevier, Paris, 40-880-B, 17 p
Brown KM, Siripurapu V, Davidson M et al (2008) Chemoradiation followed by chemotherapy before resection for borderline pancreatic adenocarcinoma. Am J Surg 195:318–321
Verslype C, Van Cutsem E, Dicato M et al (2007) The management of pancreatic cancer. Current expert opinion and recommendations derived from the 8th World Congress on Gastrointestinal Cancer, Barcelona, 2006. Ann Oncol 18(Suppl 7):vii1–vii10
Crane CH, Varadhachary G, Pisters PW et al (2007) Future chemoradiation strategies in pancreatic cancer. Semin Oncol 34:335–346
Russo S, Butler J, Ove R et al (2007) Locally advanced pancreatic cancer: a review. Semin Oncol 34:327–334
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Persiani, R., Biondi, A., Zoccali, M., D’Ugo, D. (2009). Preoperative Staging and Resectability Assessment of Pancreatic Cancer. In: Surgical Treatment of Pancreatic Diseases. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-0856-4_16
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DOI: https://doi.org/10.1007/978-88-470-0856-4_16
Publisher Name: Springer, Milano
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