Pancreatic Cancer: Pathological Factors and TNM Staging

  • Angelo de Sanctis
  • Massimiliano Rimini
  • Mario Guerrieri
Part of the Updates in Surgery book series (UPDATESSURG)


Ductal adenocarcinoma, a solid, exocrine epithelial neoplasm, represents with its variations the large majority of primitive malignant tumors of the pancreas (about 90% of cases) [1]. It is typically characterized by insidious growth with a generally unfavorable prognosis. At the time of diagnosis in most cases there are already peripancreatic lymph node metastases, and at post mortem, liver (80%), peritoneal (60%), pulmonary (50–70%), and suprarenal metastases (25%) are also frequently found [2]. Despite the recent knowledge acquired in the biomolecular genetics of this neoplasm and the progress made in instrumental diagnostic technology, the prognosis of this tumor is still poor, with an average survival of 19% at 1 year after diagnosis and 2–4% after 5 years: pancreatic cancer still has the worst prognosis of the solid neoplasms [3].


Pancreatic Cancer Hepatocyte Growth Factor Pancreatic Carcinoma Pancreatic Adenocarcinoma Uncinate Process 


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Copyright information

© Springer-Verlag Italia 2009

Authors and Affiliations

  • Angelo de Sanctis
    • 1
  • Massimiliano Rimini
    • 1
  • Mario Guerrieri
    • 1
  1. 1.Division of Minimally Invasive Surgery, Ospedali Riuniti University HospitalPolytechnic University of MarcheAnconaItaly

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