Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Diagnostic Imaging of Primary Pediatric Brain Tumors

  • Chapter
Diseases of the Brain, Head & Neck, Spine

Abstract

Pediatric brain tumors are the most common type of solid tumor among children, the second most frequent childhood malignancy after leukemia [1], and the leading cause of death from solid tumors in this population. The incidence of brain tumors in children younger than 20 years of age was 27.4 cases per million children according to the NCI’s Surveillance Epidemiology and End Results (SEER) cancer statistics reported in 2004 [2]. Approximately 9% of tumors included in the Central Brain Tumor Registry of the United States (CBTRUS) were diagnosed in children under the age of 20 [3].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gurney J, Smith M, Bunin G (1999) In: Ries L, Smith M, Gurney J (eds) CNS and miscellaneous intracranial and intraspinal neoplasms. Cancer incidence and survival among children and adolescents: United States SEER Program 1975–1995 NIH Publication No 99-4649. Bethesda, MD: National Cancer Institute SEER Program, pp 51–63

    Google Scholar 

  2. Ries L, Melbert D, Krapcho M et al (eds) (2007) SEER Cancer Statistics Review, 1975–2004. National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2004/, based on November 2006 SEER data, posted to the SEER website

    Google Scholar 

  3. CBTRUS (2005) Statistical report: primary brain tumors in the United States, 1998–2002. Central Brain Tumor Registry of the United States, Hinsdale, Illinois

    Google Scholar 

  4. Poussaint TY, Rodriguez D (2006) Advanced neuroimaging of pediatric brain tumors: MR diffusion, MR perfusion, and MR spectroscopy. Neuroimaging Clin N Am 16:169–192, ix

    Article  PubMed  Google Scholar 

  5. Sorensen A, Reimer P (2000) Cerebral MR perfusion imaging. Thieme, New York

    Google Scholar 

  6. Barkovich A (2005) Pediatric neuroimaging. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  7. Kassner A, Roberts TP (2004) Beyond perfusion: cerebral vascular reactivity and assessment of microvascular permeability. Top Magn Reson Imaging 15:58–65

    Article  PubMed  Google Scholar 

  8. Barrett T, Brechbiel M, Bernardo M, Choyke PL (2007) MRI of tumor angiogenesis. J Magn Reson Imaging 26:235–249

    Article  PubMed  Google Scholar 

  9. Golay X, Hendrikse J, Lim TC (2004) Perfusion imaging using arterial spin labeling. Top Magn Reson Imaging 15:10–27

    Article  PubMed  Google Scholar 

  10. Gauvain KM, McKinstry RC, Mukherjee P et al (2001) Evaluating pediatric brain tumor cellularity with diffusion-tensor imaging. AJR Am J Roentgenol 177:449–454

    PubMed  CAS  Google Scholar 

  11. Hamstra DA, Rehemtulla A, Ross BD (2007) Diffusion magnetic resonance imaging: a biomarker for treatment response in oncology. J Clin Oncol 25:4104–4109

    Article  PubMed  Google Scholar 

  12. Mabbott DJ, Noseworthy MD, Bouffet E et al (2006) Diffusion tensor imaging of white matter after cranial radiation in children for medulloblastoma: correlation with IQ. Neuro Oncol 8:244–252

    Article  PubMed  Google Scholar 

  13. Qiu D, Kwong DL, Chan GC et al (2007) Diffusion tensor magnetic resonance imaging finding of discrepant fractional anisotropy between the frontal and parietal lobes after wholebrain irradiation in childhood medulloblastoma survivors: reflection of regional white matter radiosensitivity? Int J Radiat Oncol Biol Phys 69:846–851

    PubMed  Google Scholar 

  14. Jolesz FA (2005) Future perspectives for intraoperative MRI. Neurosurg Clin N Am 16:201–213

    Article  PubMed  Google Scholar 

  15. Pollack IF (1994) Brain tumors in children. N Engl J Med 331:1500–1507

    Article  PubMed  CAS  Google Scholar 

  16. Louis D, Ohgaki H, Wiestler O, Cavenee W (eds) (2007) WHO classification of tumours of the central nervous system. IARC, Lyon

    Google Scholar 

  17. Ball WS Jr, Holland SK (2001) Perfusion imaging in the pediatric patient. Magn Reson Imag Clin N Am 9:207–230

    Google Scholar 

  18. Rumboldt Z, Camacho DL, Lake D et al (2006) Apparent diffusion coefficients for differentiation of cerebellar tumors in children. AJNR Am J Neuroradiol 27:1362–1369

    PubMed  CAS  Google Scholar 

  19. Law M, Yang S, Wang H et al (2003) Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging. AJNR Am J Neuroradiol 24:1989–1998

    PubMed  Google Scholar 

  20. Goh S, Butler W, Thiele EA (2004) Subependymal giant cell tumors in tuberous sclerosis complex. Neurology 63:1457–1461

    PubMed  Google Scholar 

  21. Parmar HA, Hawkins C, Ozelame R et al (2007) Fluid-attenuated inversion recovery ring sign as a marker of dysembryoplastic neuroepithelial tumors. J Comput Assist Tomogr 31:348–353

    Article  PubMed  Google Scholar 

  22. Wolff JE, Sajedi M, Brant R et al (2002) Choroid plexus tumours. Br J Cancer 87:1086–1091

    Article  PubMed  CAS  Google Scholar 

  23. Krieger MD, Panigrahy A, McComb JG et al (2005) Differentiation of choroid plexus tumors by advanced magnetic resonance spectroscopy. Neurosurg Focus 18:E4

    PubMed  Google Scholar 

  24. Panigrahy A, Krieger MD, Gonzalez-Gomez I et al (2006) Quantitative short echo time 1H-MR spectroscopy of untreated pediatric brain tumors: preoperative diagnosis and characterization. AJNR Am J Neuroradiol 27:560–572

    PubMed  CAS  Google Scholar 

  25. Aicardi J (2005) Aicardi syndrome. Brain Dev 27:164–171

    Article  PubMed  Google Scholar 

  26. Hargrave D, Bartels U, Bouffet E (2006) Diffuse brainstem glioma in children: critical review of clinical trials. Lancet Oncol 7:241–248

    Article  PubMed  Google Scholar 

  27. Laprie A, Pirzkall A, Haas-Kogan DA et al (2005) Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy. Int J Radiat Oncol Biol Phys 62:20–31

    Article  PubMed  Google Scholar 

  28. Ternier J, Wray A, Puget S et al (2006) Tectal plate lesions in children. J Neurosurg 104:369–376

    Article  PubMed  Google Scholar 

  29. Fleischman A, Brue C, Poussaint TY et al (2005) Diencephalic syndrome: a cause of failure to thrive and a model of partial growth hormone resistance. Pediatrics 115:e742–e748

    Article  PubMed  Google Scholar 

  30. Johnston JJ, Olivos-Glander I, Killoran C et al (2005) Molecular and clinical analyses of Greig cephalopolysyndactyly and Pallister-Hall syndromes: robust phenotype prediction from the type and position of GLI3 mutations. Am J Hum Genet 76:609–622

    Article  PubMed  CAS  Google Scholar 

  31. Poussaint TY, Barnes PD, Anthony DA et al (1996) Hemorrhagic pituitary adenomas of adolescence. AJNR Am J Neuroradiol 17:1907–1912

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Harvard Medical School and Department of Radiology, Division of Neuroradiology, Children’s Hospital Boston, Boston, MA, USA

    Tina Young Poussaint

Authors
  1. Tina Young Poussaint
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Hospital Balgrist, Radiology, Orthopedic University, Zurich, Switzerland

    J. Hodler

  2. Nuclear Medicine, University Hospital, Zurich, Switzerland

    G. K. Von Schulthess

  3. Kilchberg/Zurich, Switzerland

    Ch. L. Zollikofer

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag Italia

About this chapter

Cite this chapter

Poussaint, T.Y. (2008). Diagnostic Imaging of Primary Pediatric Brain Tumors. In: Hodler, J., Von Schulthess, G.K., Zollikofer, C.L. (eds) Diseases of the Brain, Head & Neck, Spine. Springer, Milano. https://doi.org/10.1007/978-88-470-0840-3_43

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-0840-3_43

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0839-7

  • Online ISBN: 978-88-470-0840-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation