Pediatric Neuroradiology

  • William S. Ball


There is nothing mystical about imaging in children. It differs from imaging in adults for three reasons: (1) Many of the more common diseases of the brain and spine encountered in children are different from those that occur in adults; there are also many diseases in children that are seldom if ever seen in adults. (2) The appearance of disease in children is often modified by the process of progressive maturation whereas in mature adults disease is often modified by the process of regressive aging — two very different processes pathophysiologically. (3) Even when “adult” diseases begin in childhood, they often appear very different by the time the child reaches maturity. The radiologist’s familiarity with these differences will allow him or her to successfully and competently perform imaging studies in children. A detailed discussion of these differences is beyond the scope of this chapter. Instead, some of the more controversial issues within the more common types of disease occurring in children under the age of 16 years will be presented here.


Sickle Cell Disease Periventricular Leukomalacia Metachromatic Leukodystrophy Glycerol Ether Pediatric Neuroradiology 


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Suggested Reading

  1. Ball WS (1991) Magnetic resonance imaging of the infant brain. Semin Ultrasound CT MR. 12:379–409PubMedGoogle Scholar
  2. Ball WS, Prenger EC, Ballard ET (1992) Neurotoxicity of radio/chemotherapy in children: pathologic and mr correlation. AJNR Am J Neuroradiol 13:761–776PubMedGoogle Scholar
  3. Barkovich AJ, Norman D (1989) Absence of the septum pellucidum: a useful sign in the diagnosis of congenital brain malformations. AJNR Am J Neuroradiol 9:1107–1114Google Scholar
  4. Barkovich AJ, Truwit CL (1990) Brain damage from perinatal asphyxia: correlation of MR findings with gestational age. AJNR Am J Neuroradiol 1:1087–1096Google Scholar
  5. Byrd SE, Osborn RE, Bohan TP, Niadich TP (1989) The CT and MR evaluation of migrational disorders of the brain. Pediatr Radiol 19:219–222PubMedCrossRefGoogle Scholar
  6. Byrd SE, Osborn RE, Radkowski MA et al (1988) Disorders of midline structures: holoprosencephaly, absence of corpus callosum, and Chiari malformation. Semin Ultrasound CT MR 9:201–215PubMedGoogle Scholar
  7. Flodmark O, Roland EH, Hill A, Whitfield MF (1987) Periventricular leukomalacia: radiologic diagnosis Radiology 162:119–124PubMedGoogle Scholar
  8. Graves VB, Duff TA (1990) Intracranial arteriovenous malformations: current imaging and treatment. Invest Radiol 25:952–960PubMedCrossRefGoogle Scholar
  9. Kjos BO, Umansky R, Barkovich AJ (1990) Brain MR imaging in children with developmental retardation of unknown cause: results in 76 cases. AJNR Am J Neuroradiol 1:1035–1040Google Scholar
  10. Nowell MA, Grossman RI, Hackney DB et al (1988) MR imaging of white matter disease in children. AJR Am J Roentgenol 151:359–365PubMedGoogle Scholar
  11. Pavlakis SG, Gould RJ, Zito JL (1991) Stroke in children. Adv Pediatr 38:151–179PubMedGoogle Scholar
  12. Pollei SR, Boyer RS, Crawford S et al (1988) Disorders of migration and sulcation. Semin Ultrasound CT MR 9:231–246PubMedGoogle Scholar
  13. Rorke LB (1990) Demystifying malformations. AJNR Am J Neuroradiol 11:675PubMedGoogle Scholar
  14. Sato Y, Yuh WTC, Smith WL et al (1989) Head injury in child abuse: evaluation with MR imaging. Radiology 173:653–657PubMedGoogle Scholar
  15. Tzika AA, Ball, Jr WS, Vigneron DB et al (1993) Childhood adrenoleukodystrophy: assessment with proton MR spectroscopy. Radiology 189:467–480PubMedGoogle Scholar
  16. Valk J, van der Knaap MS (1989) Magnetic resonance of myelin, myelination, and myelin disorders. Springer-Verlag, New York, p 82Google Scholar
  17. Wilson DA, Steiner RE (1986) Periventricular leukomalacia: evaluation with MR imaging. Radiology 160:507–511PubMedGoogle Scholar
  18. Withers HR, Peters LJ, Kogelnik HS (1980) The pathobiology of late effects of irradiation. In: Meyn RE, Withers HR (eds) Radiation biology in cancer research. Raven, New York, pp 439–448Google Scholar

Copyright information

© Springer-Verlag Italia 2008

Authors and Affiliations

  • William S. Ball
    • 1
  1. 1.Biomedical Engineering, Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiUSA

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