Extrapyramidal Syndromes: PET and SPECT

  • Klaus Tatsch


Extrapyramidal syndromes or diseases belong to the most common neurologic illnesses. Since new and promising therapeutic options are currently under development, there is a substantial demand for functional imaging procedures that have the potential to identify the pathologic changes of those illnesses. This chapter gives an overview of the current major positron emission tomography (PET) and single photon emission computed tomography (SPECT) applications in this context.


Single Photon Emission Compute Tomography Multiple System Atrophy Dementia With Lewy Body Progressive Supranuclear Palsy Essential Tremor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Suggested Reading

  1. Booij J, Tissingh G, Winogrodzka A, van Royen EA (1999) Imaging of the dopaminergic neurotransmission system using single-photon emission tomography and positron emission tomography in patients with parkinsonism. Eur J Nucl Med 26:171–182PubMedCrossRefGoogle Scholar
  2. Brooks DJ (2000) Morphological and functional imaging studies on the diagnosis and progression of Parkinson’s disease. J Neurol 247:11–18CrossRefGoogle Scholar
  3. Brooks DJ (2004) Neuroimaging in Parkinson’s disease. NeuroRx 1:243–254PubMedCrossRefGoogle Scholar
  4. Eckert T, Barnes A, Dhawan V et al (2005) FDG PET in the differential diagnosis of parkinsonian disorders. Neuroimage 26:912–921PubMedCrossRefGoogle Scholar
  5. Feigin A, Lewis D, Huang CR et al (2005) Parkinsonian patients without evidence of a dopaminergic deficit: an F-dopa and FDG PET study. Neurology 64:A234–A235Google Scholar
  6. Gerschlager W, Bencsits G, Pirker W et al (2002) [123I]beta-CIT SPECT distinguishes vascular parkinsonism from Parkinson’s disease. Mov Disord 17:518–523PubMedCrossRefGoogle Scholar
  7. Koch W, Hamann C, Radau PE, Tatsch K (2007) Does combined imaging of the pre-and postsynaptic dopaminergic system increase the diagnostic accuracy in the differential diagnosis of parkinsonism? Eur J Nucl Med Mol Imaging 34:1265–1273PubMedCrossRefGoogle Scholar
  8. McKeith I, O’Brien J, Walker Z et al (2007) Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol 6:305–313PubMedCrossRefGoogle Scholar
  9. Morrish PK, Rakshi JS, Bailey DL et al (1998) Measuring the rate of progression and estimating the preclinical period of Parkinson’s disease with F-18 dopa PET. J Neurol Neurosurg Psychiatry 64:314–319PubMedCrossRefGoogle Scholar
  10. Piccini P, Whone A (2004) Functional brain imaging in the differential diagnosis of Parkinson’s disease. Lancet Neurol 3:284–390PubMedCrossRefGoogle Scholar
  11. Pirker W, Holler I, Gerschlager W et al (2003) Measuring the rate of progression of Parkinson’s disease over a 5-year period with beta-CIT SPECT. Mov Disord 18:1266–1272PubMedCrossRefGoogle Scholar
  12. Plotkin M, Amthauer H, Klaffke S et al (2005) Combined 123I-FPCIT and 123I-IBZM SPECT for the diagnosis of parkinsonian syndromes: study on 72 patients. J Neural Transm 112:677–692PubMedCrossRefGoogle Scholar
  13. Ravina B, Eidelberg D, Ahlskog JE et al (2005) The role of radiotracer imaging in Parkinson disease. Neurology 64:208–215PubMedGoogle Scholar
  14. Scherfler C, Schwarz J, Antonini A et al (2007) Role of DAT SPECT in the diagnostic work-up of parkinsonism. Mov Disord 22:1229–1238PubMedCrossRefGoogle Scholar
  15. Seibyl J, Jennings D, Tabamo R, Marek K (2004) Neuroimaging trials of Parkinson’s disease progression. J Neurol 251Suppl 7:vII9–vII13PubMedCrossRefGoogle Scholar
  16. Seibyl J, Jennings D, Tabamo R, Marek K (2005) Unique roles of SPET brain imaging in clinical and research studies. Lessons from Parkinson’s disease research. Q J Nucl Med Mol Imaging 49:215–221PubMedGoogle Scholar
  17. Tatsch K (2008) Imaging of the dopaminergic system in differential diagnosis of dementia. Eur J Nucl Med Mol Imaging DOI 10.1007/s00259-007-0702-0Google Scholar
  18. Thobois S, Jahanshahi M, Pinto S et al (2004) PET and SPECT functional imaging studies in Parkinsonian syndromes: from the lesion to its consequences. Neuroimage 23:1–16PubMedCrossRefGoogle Scholar
  19. Zijlmans J, Evans A, Fontes F et al (2007) [(123)I] FP-CIT spect study in vascular parkinsonism and Parkinson’s disease. Mov Disord 22:1278–1285PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2008

Authors and Affiliations

  • Klaus Tatsch
    • 1
  1. 1.Department of Nuclear MedicineUniversity Hospital — Großhadern, Ludwig-Maximilians-University MunichMunichGermany

Personalised recommendations