Imaging of Central Nervous System Disease in Pediatrics

  • Tina Young Poussaint


Pediatric Neuroradiology, a radiologic discipline in which neuroimaging techniques are used to assess central nervous system (CNS) disease in the infant, child, and teenager, relies on: (1) an understanding of normal brain development and maturation from gestation through adolescence; (2) a technical mastery of the neuroimaging techniques that are used in evaluating brain diseases of childhood; (3) an overall grasp of the imaging features of numerous brain pathologies, both acquired and congenital; and (4) the ability to select the most appropriate modality or modalities in evaluating a suspected or diagnosed case of pediatric CNS disease.


Single Photon Emission Compute Tomography Apparent Diffusion Coefficient Tuberous Sclerosis Complex Central Nervous System Disease Vestibular Schwannomas 
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  1. 1.
    Barkovich AJ (2005) Pediatric neuroimaging. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  2. 2.
    Veyrac C, Couture A, Saguintaah M, Baud C (2006) Brain ultrasonography in the premature infant. Pediatr Radiol 36:626–635PubMedCrossRefGoogle Scholar
  3. 3.
    Daneman A, Epelman M, Blaser S, Jarrin JR (2006) Imaging of the brain in full-term neonates: does sonography still play a role? Pediatr Radiol 36:636–646PubMedCrossRefGoogle Scholar
  4. 4.
    Bammer R (2003) Basic principles of diffusion-weighted imaging. Eur J Radiol 45:169–184PubMedCrossRefGoogle Scholar
  5. 5.
    Roberts TP, Schwartz ES (2007) Principles and implementation of diffusion-weighted and diffusion tensor imaging. Pediatr Radiol 37:739–748PubMedCrossRefGoogle Scholar
  6. 6.
    Mukherjee P, McKinstry RC (2006) Diffusion tensor imaging and tractography of human brain development. Neuroimaging Clin N Am 16:19–43, viiPubMedCrossRefGoogle Scholar
  7. 7.
    Robertson RL, Glasier CM (2007) Diffusion-weighted imaging of the brain in infants and children. Pediatr Radiol 37:749–768PubMedCrossRefGoogle Scholar
  8. 8.
    Rollins NK (2007) Clinical applications of diffusion tensor imaging and tractography in children. Pediatr Radiol 37:769–780PubMedCrossRefGoogle Scholar
  9. 9.
    Medina LS, Bernal B, Dunoyer C et al (2005) Seizure disorders: functional MR imaging for diagnostic evaluation and surgical treatment — prospective study. Radiology 236:247–253PubMedCrossRefGoogle Scholar
  10. 10.
    Zarifi MK, Astrakas LG, Poussaint TY et al (2002) Prediction of adverse outcome with cerebral lactate level and apparent diffusion coefficient in infants with perinatal asphyxia. Radiology 225:859–870PubMedCrossRefGoogle Scholar
  11. 11.
    Tong KA, Ashwal S, Obenaus A et al (2007) Susceptibility-weighted MR imaging: a review of clinical applications in children. AJNR Am J Neuroradiol 29:9–17PubMedCrossRefGoogle Scholar
  12. 12.
    Frieden IJ, Reese V, Cohen D (1996) PHACE syndrome. The association of posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities. Arch Dermatol 132:307–311PubMedCrossRefGoogle Scholar
  13. 13.
    Belman AL (1992) Acquired immunodeficiency syndrome and the child’s central nervous system. Pediatr Clin N Am 39:691–714Google Scholar
  14. 14.
    Rodriguez DP, Poussaint TY (2007) Neuroimaging of the child with developmental delay. Top Magn Reson Imaging 18:75–92PubMedCrossRefGoogle Scholar
  15. 15.
    Desprechins B, Stadnik T, Koerts G et al (1999) Use of diffusion-weighted MR imaging in differential diagnosis between intracerebral necrotic tumors and cerebral abscesses. AJNR Am J Neuroradiol 20:1252–1257PubMedGoogle Scholar
  16. 16.
    Poussaint TY (2001) Magnetic resonance imaging of pediatric brain tumors: state of the art. Top Magn Reson Imaging 12:411–433PubMedCrossRefGoogle Scholar
  17. 17.
    Morris EB, Laningham FH, Sandlund JT, Khan RB (2007) Posterior reversible encephalopathy syndrome in children with cancer. Pediatr Blood Cancer 48:152–159PubMedCrossRefGoogle Scholar
  18. 18.
    McKinney AM, Short J, Truwit CL et al (2007) Posterior reversible encephalopathy syndrome: incidence of atypical regions of involvement and imaging findings. AJR Am J Roentgenol 189:904–912PubMedCrossRefGoogle Scholar
  19. 19.
    Barnes PD, Brody JD, Jaramillo D et al (1993) Atypical idiopathic scoliosis: MR imaging evaluation. Radiology 186:247–253PubMedGoogle Scholar
  20. 20.
    Poussaint TY, Moeller KK (2002) Imaging of pediatric head trauma. Neuroimaging Clin N Am 12:271–294, ixPubMedCrossRefGoogle Scholar
  21. 21.
    Schaefer PW, Huisman TA, Sorensen AG et al (2004) Diffusion-weighted MR imaging in closed head injury: high correlation with initial Glasgow coma scale score and score on modified Rankin scale at discharge. Radiology 233:58–66PubMedCrossRefGoogle Scholar
  22. 22.
    Ashwal S, Babikian T, Gardner-Nichols J et al (2006) Susceptibility-weighted imaging and proton magnetic resonance spectroscopy in assessment of outcome after pediatric traumatic brain injury. Arch Phys Med Rehabil 87:S50–S58PubMedCrossRefGoogle Scholar
  23. 23.
    Ersahin Y, Gulmen V, Palali I, Mutluer S (2000) Growing skull fractures (craniocerebral erosion). Neurosurg Rev 23:139–144PubMedCrossRefGoogle Scholar
  24. 24.
    Kleinman PK, Barnes PD (1998) Head trauma. In: Kleinman PK (ed) Diagnostic imaging of child abuse. Mosby, St. Louis, pp 285–342Google Scholar
  25. 25.
    Suh DY, Davis PC, Hopkins KL et al (2001) Nonaccidental pediatric head injury: diffusion-weighted imaging findings. Neurosurgery 49:309–318PubMedCrossRefGoogle Scholar
  26. 26.
    Sevick RJ, Barkovich AJ, Edwards MS et al (1992) Evolution of white matter lesions in neurofibromatosis type 1: MR findings. AJR Am J Roentgenol 159:171–175PubMedGoogle Scholar
  27. 27.
    Di Paolo DP, Zimmerman RA, Rorke LB et al (1995) Neurofibromatosis type 1: pathologic substrate of high-signal-intensity foci in the brain. Radiology 195:721–724Google Scholar
  28. 28.
    Smirniotopoulos JG, Murphy FM (1992) The phakomatoses. AJNR Am J Neuroradiol 13:725–746PubMedGoogle Scholar
  29. 29.
    Parry DM, Eldridge R, Kaiser-Kupfer MI et al (1994) Neurofibromatosis 2 (NF2): clinical characteristics of 63 affected individuals and clinical evidence for heterogeneity. Am J Med Genet 52:450–461PubMedCrossRefGoogle Scholar
  30. 30.
    Braffman B, Naidich TP (1994) The phakomatoses: Part I. Neurofibromatosis and tuberous sclerosis. Neuroimaging Clin N Am 4:299–324PubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 2008

Authors and Affiliations

  • Tina Young Poussaint
    • 1
  1. 1.Harvard Medical School and Department of Radiology, Division of NeuroradiologyChildren’s Hospital BostonBostonUSA

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