Skip to main content
SpringerLink
Log in
Book cover

Dioxygen Binding and Sensing Proteins pp 183–189Cite as

Myoglobin Strikes Back

  • Chapter

  • 366 Accesses

Part of the book series: Protein Reviews ((PRON,volume 9))

Abstract

The biochemical and physiological role of myoglobin is briefly reviewed with reference to the seminal work by Wittenberg and Wittenberg. The function of myoglobin as a NO scavenger in the skeletal muscle and the heart was found to protect cellular respiration, which is known to depend on inhibition of cytochrome-c-oxidase.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bates, T.E., Loesch, A., Burnstock, G., and Clark, J. B. 1995. Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochem. Biophys. Res. Commun. 213:896–900.

    Article  PubMed  CAS  Google Scholar 

  • Bredt, D.S., and Snyder, S.H. 1994. Nitric oxide: a physiologic messenger molecule. Annu. Rev. Biochem. 63:175–195.

    Article  PubMed  CAS  Google Scholar 

  • Brown, G.C. 1995. Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase. FEBS Lett. 369:136–139.

    Article  PubMed  CAS  Google Scholar 

  • Brown, G.C., and Cooper, C.E. 1994. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett. 356:295–298.

    Article  PubMed  CAS  Google Scholar 

  • Brunori, M. 2001a. Nitric oxide, cytochrome-c oxidase and myoglobin. Trends Biochem. Sci. 26:21–23.

    Article  PubMed  CAS  Google Scholar 

  • Brunori, M. 2001b. Nitric oxide moves myoglobin centre stage. Trends Biochem. Sci. 26:209–210.

    Article  PubMed  CAS  Google Scholar 

  • Brunori, M., Forte, E., Arese, M., Mastronicola, D., Giuffre, A., and Sarti P. 2006. Nitric oxide and the respiratory enzyme. Biochim. Biophys. Acta 1757:1144–1154.

    Article  PubMed  CAS  Google Scholar 

  • Brunori, M., and Vallone, B. 2006. A globin for the brain. FASEB J. 20:2192–2197.

    Article  PubMed  CAS  Google Scholar 

  • Burmester, T., Weich, B., Reinhardt, S., and Hankein, T. 2000. A vertebrate globin expressed in the brain. Nature 407:520–523.

    Article  PubMed  CAS  Google Scholar 

  • Carr, G.J., and Ferguson, S.J. 1990. Nitric oxide formed by nitrite reductase of Paracoccus denitrificans is sufficiently stable to inhibit cytochrome oxidase activity and is reduced by its reductase under aerobic conditions. Biochim. Biophys. Acta 1017:57–62.

    Article  PubMed  CAS  Google Scholar 

  • Chen, W., Zheng, J., Eljgelshoven, M. H., Zhang, Y., Zhu, X. H., Wang, C., Cho, Y., Merkle, H., and Ugurbie, K. 1997. Determination of deoxy myoglobin changes during graded myocardial ischemia: an in vivo H-NMR spectroscopy study. Magn. Reson. Med. 38:193–197.

    Article  PubMed  CAS  Google Scholar 

  • Cleeter, M. W., Cooper, J. M., Darley-Usmar, V. M., Moncada, S., and Schapira, A. H. 1994. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett. 345:50–54.

    Article  PubMed  CAS  Google Scholar 

  • Eich, R. F., Li, T., Lemon, D. D., Doherty, D. H., Curry, S. R., Altken, J. F., Mathews, A. J., Johnson, K. A., Smith, R. D., Phillips, G. N. Jr, Olson, J. S. 1996. Mechanism of NO-induced oxidation of myoglobin and hemoglobin. Biochemistry 35:6976–6983.

    Article  PubMed  CAS  Google Scholar 

  • Flögel, U., Merx, M. W., Gödecke, A., Decking, U. K. M.., and Schrader, J. 2001. Myoglobin: a scavenger of bioactive NO. Proc. Natl. Acad. Sci. U.S.A. 98:735–740.

    Article  PubMed  Google Scholar 

  • Garry, D.J., Ordway, G. A., Lorenz, J. N., Radford, N. B., Chin, E. R., Grange, R. W., Bassel-Duby, R., and Williams, R. S. 1998. Mice without myoglobin. Nature 395:905–908.

    Article  PubMed  CAS  Google Scholar 

  • Ghafourifar, P., and Richter, C. 1997. Nitric oxide synthase activity in mitochondria. FEBS Lett. 418:291–296.

    Article  PubMed  CAS  Google Scholar 

  • Giuffrè, A., Sarti, P., D’Itri, E., Buse, G., Soulimane, T., and Brunori, M. 1999. On the mechanism of inhibition of cytochrome c oxidase by nitric oxide. J. Biol. Chem. 271:33404–33408.

    Google Scholar 

  • Glabe, A., Chung, Y., Xu, D., and Jue, T. 1998. Carbon monoxide inhibition of regulatory pathways in myocardium. Am. J. Physiol 234:H2143–H2151.

    Google Scholar 

  • Gödecke, A., Flögel, U., Zanger, K., Ding, Z., Hirchenhain, J., Decking, U. K. M, and Schrader, J. 1999. Disruption of myoglobin in mice induces multiple compensatory mechanisms. Proc. Natl. Acad. Sci. U.S.A. 96:10495–10500.

    Article  PubMed  Google Scholar 

  • Ignarro, L.J., Buga, G. M., Wood, K. S., Byrns, R. E., and Chaudhuri, G. 1987. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. U. S. A. 84:9265–9269.

    Article  PubMed  CAS  Google Scholar 

  • Mason, M.G., Nicholls, P., Wilson, M. T., and Cooper, C. E. 2006. Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome c oxidase. Proc. Natl. Acad. Sci. U. S. A. 103:708–713.

    Article  PubMed  CAS  Google Scholar 

  • Palmer, R.M., Ferrige, A.G., and Moncada, S. 1987. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524–526.

    Article  PubMed  CAS  Google Scholar 

  • Persichini, T., Mazzone, V., Polticelli, F., Moreno, S., Venturini, G., Clementi, E., and Colasanti, M. 2005. Mitochondrial type I nitric oxide synthase physically interacts with cytochrome c oxidase. Neurosci. Lett. 384:254–295.

    Article  PubMed  CAS  Google Scholar 

  • Sarti, P., Giuffre, A., Barone, M. C., Forte, E., Mastronicola, D., and Brunori, M. 2003. Nitric oxide and cytochrome oxidase: reaction mechanism from the enzyme to the cell. Free Radic. Biol. Med. 34:509–520.

    Article  PubMed  CAS  Google Scholar 

  • Scholander, P.F. 1960. Oxygen transport through hemoglobin solutions. Science 131:585–590.

    Article  PubMed  CAS  Google Scholar 

  • Tatoyan, A., and Giulivi, C. 1998. Purification and characterization of a nitric oxide synthase from rat liver mitochondrial. J. Biol. Chem. 273:11044–11048.

    Article  PubMed  CAS  Google Scholar 

  • Torres, J., Cooper, C.E., and Wilson, M.T. 1998. A common mechanism for the interaction of nitric oxide with the oxidized binuclear centre and oxygen intermediates of cytochrome c oxidase. J. Biol. Chem. 273:8756–8766.

    Article  PubMed  CAS  Google Scholar 

  • Torres, J., Darley-Usmar, V., and Wilson, M.T. 1995. Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration. Biochem. J. 312:169–173.

    PubMed  CAS  Google Scholar 

  • Wittenberg, B.A., and Wittenberg, J.B. 1987. Myoglobin-mediated oxygen delivery to mitochondria of isolated cardiac myocytes. Proc. Natl. Acad. Sci. U.S.A. 84:7503–7507.

    Article  PubMed  CAS  Google Scholar 

  • Wittenberg, J.B, and Wittenberg, B.A. 2003. Myoglobin function reassessed. J. Exp. Biol. 206:2011–2020.

    Article  PubMed  CAS  Google Scholar 

  • Wittenberg, J.B. 1959. Oxygen transport: a new function proposed for myoglobin. Biol. Bull. 117:402–403.

    Google Scholar 

  • Wittenberg, J.B. 1963. Facilitated diffusion of oxygen through haemerythrin solutions. Nature 199:816–817.

    Article  PubMed  CAS  Google Scholar 

  • Wittenberg, J.B. 1966. The molecular mechanism of hemoglobin-facilitated oxygen diffusion. J. Biol. Chem. 241:104–114.

    PubMed  CAS  Google Scholar 

  • Wyman, J. 1966. Facilitated diffusion and the possible role of myoglobin as a transport mechanism. J. Biol. Chem. 241:115–121.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemical Sciences, University of Rome “La Sapienza”, Rome, Italy

    Maurizio Brunori

Authors
  1. Maurizio Brunori
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biomolecular Sciences and Biotechnology, University of Milan, Milan, Italy

    Martino Bolognesi

  2. Institute of Protein Biochemistry, CNR, Naples, Italy

    Guido di Prisco  & Cinzia Verde  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag Italia

About this chapter

Cite this chapter

Brunori, M. (2008). Myoglobin Strikes Back. In: Bolognesi, M., di Prisco, G., Verde, C. (eds) Dioxygen Binding and Sensing Proteins. Protein Reviews, vol 9. Springer, Milano. https://doi.org/10.1007/978-88-470-0807-6_15

Download citation

Publish with us

Policies and ethics

Search

Navigation