Myoglobin Strikes Back
The biochemical and physiological role of myoglobin is briefly reviewed with reference to the seminal work by Wittenberg and Wittenberg. The function of myoglobin as a NO scavenger in the skeletal muscle and the heart was found to protect cellular respiration, which is known to depend on inhibition of cytochrome-c-oxidase.
KeywordsNitric Oxide Paracoccus Denitrificans Intermediate Oxidation State Binuclear Centre Isolate Mouse Heart
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- Cleeter, M. W., Cooper, J. M., Darley-Usmar, V. M., Moncada, S., and Schapira, A. H. 1994. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett. 345:50–54.PubMedCrossRefGoogle Scholar
- Giuffrè, A., Sarti, P., D’Itri, E., Buse, G., Soulimane, T., and Brunori, M. 1999. On the mechanism of inhibition of cytochrome c oxidase by nitric oxide. J. Biol. Chem. 271:33404–33408.Google Scholar
- Glabe, A., Chung, Y., Xu, D., and Jue, T. 1998. Carbon monoxide inhibition of regulatory pathways in myocardium. Am. J. Physiol 234:H2143–H2151.Google Scholar
- Wittenberg, J.B. 1959. Oxygen transport: a new function proposed for myoglobin. Biol. Bull. 117:402–403.Google Scholar