Human Serum Haeme-albumin: An Allosteric ‘Chronosteric’ Protein
Serum albumin (SA) participates in plasma haeme scavenging. Sequestering the haeme, SA accounts for most of the antioxidant capacity of plasma. In turn, serum haeme albumin (SA-haeme) displays ligand-binding and pseudoenzymatic properties. Recently, engineered SA-haeme has been proposed as an O2 carrier not only for red blood cell substitutes but also as an O2-therapeutic agent. Eventually, SA-haeme could be considered an allosteric ‘chronosteric’ haeme-protein, the transient haeme-based reactivity being modulated by third components.
KeywordsHuman Serum Albumin Sperm Whale Acute Intermittent Porphyria Ligand Binding Property Porphyrin Plane
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