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Cerebrovascular Disease in HIV-Infected Patients

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Cardiovascular Disease in AIDS
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Abstract

Neurological complications of HIV-1 infection, due either to the immunosuppression (opportunistic infections and neoplasms) or the neurotropism of the virus, are common and add considerably to the morbidity and mortality of the infection. Their frequency varies according to the stage of the disease. They have been reported to represent 10–15% of symptomatic primo-infection, and are the first manifestation of AIDS in 10–20% of symptomatic HIV-1 infection cases. Their prevalence in clinical studies has been estimated to range from 40 to 70%, and a prospective study revealed that neurological findings were present in 90% of AIDS patients examined by a neurologist

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References

  1. Malouf R, Jacquette G, Dobkin J, Brust JCM (1990) Neurologic disease in human immunodeficiency virus-infected drug abusers. Arch Neurol 47:1002–1007

    CAS  PubMed  Google Scholar 

  2. Moulignier A (2006) HIV and the central nervous system. Rev Neurol (Paris) 162:22–42

    CAS  Google Scholar 

  3. Moulignier A, Moulonguet A (2007) Complications neurologiques. In: Katalama C, Girard P-M, Pialoux G (eds) VIH 2007. Doin, Reuil Malmaison, pp 97–133

    Google Scholar 

  4. Sacktor N (2002) The epidemiology of human immunodeficiency virus-associated neurological disease in the era of highly active antiretroviral therapy. J Neurovirol 8(Suppl 2):115–121

    CAS  PubMed  Google Scholar 

  5. Gray F, Bazille C, Addle-Biassette H et al (2005) Central nervous system immune reconstitution disease in AIDS patients receiving highly active antiretroviral treatment. J Neurovirol 11(Suppl 3):16–22

    PubMed  Google Scholar 

  6. Scaravilli F, Bazille C, Gray F (2007). Neuropathologic contributions to understanding AIDS and the central nervous system. Brain Pathol 17:197–208

    PubMed  Google Scholar 

  7. Jellinger KA, Setinek U, Drlicek M et al (2000) Neuropathology and general autopsy findings in AIDS during the last 15 years. Acta Neuropathol 100:213–220

    CAS  PubMed  Google Scholar 

  8. Snider WD, Simpson DM, Nielsen S et al (1983) Neurological complications of acquired immune deficiency syndrome: analysis of 50 patients. Ann Neurol 14:403–418

    CAS  PubMed  Google Scholar 

  9. Rabinstein AA (2003) Stroke in HIV-infected patients: a clinical perspective. Cerebrovasc Dis 15:37–44

    PubMed  Google Scholar 

  10. Kamin DS, Grinspoon SK (2005) Cardiovascular disease in HIV-positive patients. AIDS 19:641–652

    PubMed  Google Scholar 

  11. d’Arminio Monforte A, Bongiovanni M (2005) Cerebrovascular disease in highly active antiretroviral therapy-treated individuals: incidence and risk factors. J Neurovirol 11(Suppl 3):34–47

    Google Scholar 

  12. Moulignier A (2007) Dementia due to HIV disease and aging. Psychol Neuropsychiatr Vieil 5:1–15

    Google Scholar 

  13. Pinto AN (1996) AIDS and cerebrovascular disease. Stroke 27:538–543

    CAS  PubMed  Google Scholar 

  14. Ortiz G, Koch S, Romano JG et al (2007) Mechanisms of ischemic stroke in HIV-infected patients. Neurology 68:1257–1261

    CAS  PubMed  Google Scholar 

  15. Tipping B, de Villiers L, Wainwright H et al (2007) Stroke in patients with human immunodeficiency virus infection. J Neurol Neurosurg Psychiatry 78:1320–1324

    PubMed  Google Scholar 

  16. Cole JW, Pinto AN, Hebel JR et al (2004) Acquired immunodeficiency syndrome and the risk of stroke. Stroke 35:51–56

    PubMed  Google Scholar 

  17. Levy RM, Bredesen DE (1988) Central nervous system dysfunction in acquired immunodeficiency syndrome. J Acquir Immune Defic Syndr 1:41–64

    CAS  PubMed  Google Scholar 

  18. Evers S, Nabavi D, Rahmann A et al (2003) Ischaemic cerebrovascular events in HIV infection: a cohort study. Cerebrovasc Dis 15:199–205

    PubMed  Google Scholar 

  19. Hoffmann M, Berger JR, Nath A, Rayens (2000) Cerebrovascular disease in young, HIV-infected black Africans in the KwaZulu natal province of South Africa. J Neurovirol 6:229–236

    CAS  PubMed  Google Scholar 

  20. d’Arminio A, Sabin CA, Phillips AN et al; Writing Committee of the DAD Study Group (2004) Cardioand cerebrovascular events in HIV-infected persons. AIDS 18:1811–1817

    PubMed  Google Scholar 

  21. Bozzette SA, Ake CF, Tam HK et al (2003) Cardiovascular and cerebrovascular events in patients treated for human immunodeficiency virus infection. N Engl J Med 348:702–710

    CAS  PubMed  Google Scholar 

  22. Holmberg SD, Moorman AC, Williamson JM et al (2002) Protease inhibitors and cardiovascular outcomes in patients with HIV-1. Lancet 306:1747–1748

    Google Scholar 

  23. Levy RM, Bredesen DE, Rosenblum ML (1985) Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. J Neurosurg 62:475–495

    CAS  PubMed  Google Scholar 

  24. Koppel BS, Wormser GP, Tuchman AJ et al (1985) Central nervous system involvement in patients with acquired immunodeficiency syndrome (AIDS). Acta Neurol Scand 71:337–353

    Article  CAS  PubMed  Google Scholar 

  25. Berger JR, Moskowitz L, Fischl M, Kelley RE (1987) Neurological disease as the presenting manifestation of acquired immunodeficiency syndrome. South Med J 80:683–686

    CAS  PubMed  Google Scholar 

  26. McArthur JC (1987) Neurological manifestations of AIDS. Medicine 66:407–437

    CAS  PubMed  Google Scholar 

  27. Engstrom JW, Lowenstein DH, Bredesen DE (1989) Cerebral infarctions and transient neurologic deficits associated with acquired immunodeficiency syndrome. Am J Med 86:528–532

    CAS  PubMed  Google Scholar 

  28. Moskowitz LB, Hensley GT, Chan JC et al (1984) The neuropathology of acquired immunodeficiency syndrome. Arch Pathol Lab Med 108:867–872

    CAS  PubMed  Google Scholar 

  29. Anders KH, Guerra WF, Tomiyasu U, Vinters HV (1986) The neuropathology of AIDS: UCLA experience and review. Am J Pathol 124:537–558

    CAS  PubMed  Google Scholar 

  30. Rosemberg S, Lopes MBS, Tsanadis AM (1986) Neuropathology of acquired immunodeficiency syndrome: analysis of 22 Brazilian cases. J Neurol Sci 76:187–198

    CAS  PubMed  Google Scholar 

  31. Mizusawa H, Hirano A, Llena SF, Shintaku M (1988) Cerebrovascular lesions of AIDS. Acta Neuropathol 76:451–457

    CAS  PubMed  Google Scholar 

  32. Esiri MM, Scaravilli F, Millard PR, Harcourt-Webster JN (1989) Neuropathology of HIV infection in hemophiliacs: comparative necropsy study. Br Med J 299:1312–1315

    CAS  Google Scholar 

  33. Berger JR, Harris JO, Gragorios J, Norenberg M (1990) Cerebrovascular disease in AIDS: a case control study. AIDS 4:239–244

    CAS  PubMed  Google Scholar 

  34. Kieburtz KD, Eskin TA, Ketonen L, Tuite MJ (1993) Opportunistic cerebral vasculopathy and stroke in patients with AIDS. Arch Neurol 50:430–432

    CAS  PubMed  Google Scholar 

  35. Connor MD, Lammie GA, Bell JE et al (2000) Cerebral infarction in adult AIDS patients: observations from the Edinburgh HIV Autopsy Cohort. Stroke 31:2117–2126

    CAS  PubMed  Google Scholar 

  36. Gillams AR, Allen E, Hrieb K et al (1997) Cerebral infarction in patients with AIDS. Am J Neuroradiol 18:1581–1585

    CAS  PubMed  Google Scholar 

  37. Grindal AB, Cohen RJ, Saul RF et al (1978) Cerebral infarction in young adults. Stroke 9:39–42

    CAS  PubMed  Google Scholar 

  38. Kristensen B, Malm J, Carlberg B et al (1997) Epidemiology and etiology of ischemic stroke in young adults aged 18 to 44 years in northern Sweden. Stroke 28:1702–1709

    CAS  PubMed  Google Scholar 

  39. Berger K, Schulte H, Stögbauer F, Assmann G (1998) Incidence and risk factors for stroke in an occupational cohort: the PROCAM study. Stroke 29:1562–1566

    CAS  PubMed  Google Scholar 

  40. Qureshi AI, Janssen RS, Karon JM et al (1997) Human immunodeficiency virus infection and stroke in young patients. Arch Neurol 54:1150–1153

    CAS  PubMed  Google Scholar 

  41. Bajwa ZH, Libman R, Lipton RB et al (1991) Cerebrovascular disease in patients with HIV. Neurology 41(Suppl 1):S295

    Google Scholar 

  42. Baily GG, Mandal BK (1995) Recurrent transient neurological deficits in advanced HIV infection. AIDS 9:709–712

    CAS  PubMed  Google Scholar 

  43. Brew BJ, Miller J (1996) Human immunodeficiency virus type 1-related transient neurological deficits. Am J Med 10:257–261

    Google Scholar 

  44. Rinaldi R, Manfredi R, Azzimondi G et al (1997) Recurrent ‘migrainelike’ episodes in patients with HIV disease. Headache 37:443–448

    CAS  PubMed  Google Scholar 

  45. Klein JL, Price DA, Fisher M, Coker RJ (1996) Cytomegalovirus infection: a possible cause of recurrent transient neurological dysfunction in advanced HIV infection. AIDS 10:345–346

    CAS  PubMed  Google Scholar 

  46. Card T, Wathen CG, Luzzi GA (1998) Primary HIV-1 infection presenting with transient neurological deficit. J Neurol Neurosurg Psychiatry 6:281–282

    Google Scholar 

  47. Atalaia A, Ferro J, Antunes F (1992) Stroke in an HIV-infected patient. J Neurol 239:356–357

    CAS  PubMed  Google Scholar 

  48. Bradley TP, Vas G (1997) HIV type-1-related transient neurologic deficits. Am J Med 103:250

    CAS  PubMed  Google Scholar 

  49. Zunker P, Nabavi DG, Allardt A et al (1996) HIVassociated stroke: report of two unusual cases. Stroke 27:1694–1696

    CAS  PubMed  Google Scholar 

  50. Vittecoq D, Escaut L, Monsuez JJ (1998) Vascular complications associated with use of HIV protease inhibitors. Lancet 351:1959

    CAS  PubMed  Google Scholar 

  51. Casado-Naranjo I, Toledo-Santos JA, Antolin-Rodriguez MA (1992) Ischemic stroke as the sole manifestation of HIV infection. Stroke 23:117–118

    CAS  PubMed  Google Scholar 

  52. Mochan A, Modi M, Modi G (2003) Stroke in black South African HIV-positive patients: a prospective analysis. Stroke 34:10–15

    PubMed  Google Scholar 

  53. Roldan EO, Moskowitz L, Hensley GT (1987) Pathology of the heart in acquired immunodeficiency syndrome. Arch Pathol Lab Med 111:943–946

    CAS  PubMed  Google Scholar 

  54. Lai WW, Colan SD, Easley KA et al (2001) Dilation of the aortic root in children infected with human immunodeficiency virus type 1: The Prospective P2C2 HIV Multicenter Study. Am Heart J 141:661–670

    CAS  PubMed  Google Scholar 

  55. Anders KH, Latta H, Chang BS et al (1989) Lymphomatoid granulomatosis and malignant lymphoma of the central nervous system in the acquired immunodeficiency syndrome. Hum Pathol 20:326–334

    CAS  PubMed  Google Scholar 

  56. Geier SA, Perro C, Klauss V et al (1993) HIV-related ocular microangiopathic syndrome and cognitive functioning. J Acquir Immune Defic Syndr 6:252–258

    CAS  PubMed  Google Scholar 

  57. Scaravilli F, Daniel SE, Harcourt-Webster N, Guiloff RJ (1989) Chronic basal meningitis and vasculitis in acquired immunodeficiency syndrome: a possible role for human immunodeficiency virus. Arch Pathol Lab Med 113:192–195

    CAS  PubMed  Google Scholar 

  58. Yankner BA, Skolnik PR, Shoukimas GM et al (1986) Cerebral granulomatous angiitis associated with isolation of human T-lymphotropic virus type III from the central nervous system. Ann Neurol 20:362–364

    CAS  PubMed  Google Scholar 

  59. Nogueras C, Sala M, Sasal M et al (2002) Recurrent stroke as a manifestation of primary angiitis of the central nervous system in a patient infected with human immunodeficiency virus. Arch Neurol 59:468–473

    PubMed  Google Scholar 

  60. Evidente V, Yagnik P (1995) Stroke and stroke-like syndromes in the acquired immunodeficiency syndrome. Neurology 45(Suppl 4):A444

    Google Scholar 

  61. Brannagan TH (1997) Retroviral-associated vasculitis of the nervous system. Neurol Clin 15:927–944

    PubMed  Google Scholar 

  62. van der Ven AJ, van Oostenbrugge RJ, Kubat B, Tervaert JW (2002) Cerebral vasculitis after initiation of antiretroviral therapy. AIDS 16:2362–2364

    PubMed  Google Scholar 

  63. Dehais C, Moulignier A, Deschamps R et al (2004) Immune reconstitution vasculitis in an HIV-infected patient (abstract). Program of the Journées de Neurologie de Langue Française, Strasbourg

    Google Scholar 

  64. Moulignier A, Laloum L, Chauveau E et al (2003) HIV-1-related ischaemic trochlear nerve palsy. J Neurol 250:108–109

    PubMed  Google Scholar 

  65. Brilla R, Nabavi DG, Schulte-Atedorneburg G et al (1999) Cerebral vasculopathy in HIV infection revealed by transcranial Doppler: a pilot study. Stroke 30:811–813

    CAS  PubMed  Google Scholar 

  66. Tran Dinh YR, Mamo H, Cervoni J et al (1990) Disturbances in the cerebral perfusion of human immune deficiency virus-1 seropositive asymptomatic subjects: a quantitative tomography study of 18 cases. J Nucl Med 31:1601–1607

    CAS  PubMed  Google Scholar 

  67. Tipping B, de Villiers L, Candy S, Wainwright H (2006) Stroke caused by human immunodeficiency virus-associated intracranial large-vessel aneurysmal vasculopathy. Arch Neurol 63:1640–1642

    PubMed  Google Scholar 

  68. Feldman JG, Goldwasser P, Holman S et al (2003) C-reactive protein is an independent predictor of mortality in women with HIV-1 infection. J Acquir Immune Defic Syndr 32:210–214

    CAS  PubMed  Google Scholar 

  69. Rhew DC, Bernal M, Aguilar D et al (2003) Association between protease inhibitor use and increased cardiovascular risk in patients infected with human immunodeficiency virus: a systematic review. Clin Infect Dis 31:959–972

    Google Scholar 

  70. Maggi P, Serio G, Epifani G et al (2000) Premature lesions of the carotid vessels in HIV-1-infected patients treated with protease inhibitors. AIDS 14:123–128

    Google Scholar 

  71. de Saint Martin L, Vandhuic O, Guillo P et al (2006) Premature atherosclerosis in HIV positive patients and cumulated time of exposure to antiretroviral therapy (SHIVA study). Atherosclerosis 185:361–367

    PubMed  Google Scholar 

  72. Seminari E, Pan A, Voltini G et al (2002). Assessment of atherosclerosis using carotid ultrasonography in a cohort of HIV-positive patients treated with protease inhibitors. Atherosclerosis 162:433–438

    CAS  PubMed  Google Scholar 

  73. Mercié P, Thiébaut R, Aurillac-Lavignolle V et al (2005) Carotid intima-media thickness is slightly increased over time in HIV-1-infected patients. HIV Med 6:380–387

    PubMed  Google Scholar 

  74. Depayron M, Chessex S, Sudre P et al (2001) Premature atherosclerosis in HIV-infected individuals: focus on protease inhibitor therapy. AIDS 15:329–334

    Google Scholar 

  75. Jerico C, Knobel H, Calvo N et al (2006) Subclinical carotid atherosclerosis in HIV-infected patients: role of combination antiretroviral therapy. Stroke 37:812–817

    PubMed  Google Scholar 

  76. Hsue PY, Lo JC, Franklin A et al (2004) Progression of atherosclerosis as assessed by carotid intimamedia thickness in patients with HIV infection. Circulation 109:1603–1609

    PubMed  Google Scholar 

  77. Thiébaut R, Aurillac-Lavignolle V, Bonnet F et al (2005). Change in atherosclerosis progression in HIV infected patients: ANRS Aquitaine cohort, 1999–2004. AIDS 19:729–731

    PubMed  Google Scholar 

  78. Currier JS, Kendall MA, Henry WK et al (2007) Progression of carotid intima-media thickening in HIV-infected and uninfected adults. AIDS 21:1137–1145

    PubMed  Google Scholar 

  79. Hollander M, Hak AE, Koudstaal PJ et al (2003) Comparison between measures of atherosclerosis and risk of stroke: the Rotterdam Study. Stroke 34:2367–2372

    CAS  PubMed  Google Scholar 

  80. Van Oijen M, de Jong FJ, Witteman JCM et al (2007) Atherosclerosis and risk for dementia. Ann Neurol 61:403–410

    PubMed  Google Scholar 

  81. Bock AR, Schwab J, Marienhagen J et al (1994) Anticardiolipin antibodies in HIV infection: associated with cerebral perfusion defects as detected by 99mTc-HMPAO SPECT. Clin Exp Immunol 98:361–368

    PubMed  Google Scholar 

  82. Brey RL, Chapman J, Levine SR et al (2003) Stroke and the antiphospholipid syndrome: consensus meeting, Taormina 2002. Lupus 12:508–513

    CAS  PubMed  Google Scholar 

  83. Hassell KL, Kressin DC, Neumann A, Ellison R, Marlar RA (1994) Correlation of antiphospholipid antibodies and protein S deficiency with thrombosis in HIV-infected men. Blood Coagul Fibrinolysis 5:455–462

    CAS  PubMed  Google Scholar 

  84. Mochan A, Modi M, Modi G (2005) Protein S deficiency in HIV associated ischaemic stroke: an epiphenomenon of HIV infection. J Neurol Neurosurg Psychiatry 76:1455–1456

    CAS  PubMed  Google Scholar 

  85. Martin CM, Matlow AG, Chew E et al (1989) Hyperviscosity syndrome in a patient with acquired immunodeficiency syndrome. Arch Intern Med 149:1435–1436

    CAS  PubMed  Google Scholar 

  86. Bruno A (2003) Cerebrovascular complications of alcohol and sympathomimetic drug abuse. Curr Neurol Neurosci Rep 3:40–45

    PubMed  Google Scholar 

  87. Hanyu S, Ikeguchi K, Imai H et al (1995) Cerebral infarction associated with 3,4-methylenedioxymethamphetamine (’ecstasy’) abuse. Eur Neurol 35:173

    CAS  PubMed  Google Scholar 

  88. Strobel M, Lamaury I, Brouzes F et al (1995) Accidents vasculaires cérébraux et sida. Rev Med Interne 16:743–746

    CAS  PubMed  Google Scholar 

  89. Moulignier A, Baudrimont M, Martin-Negrier ML et al (1996) Fatal brain stem encephalitis due to herpes simplex virus type 1 in AIDS. J Neurol 243:491–493

    CAS  PubMed  Google Scholar 

  90. Brust JC (2002) Neurologic complications of substance abuse. J Acquir Immune Defic Syndr 31(Suppl 2):S29–S34

    CAS  PubMed  Google Scholar 

  91. Nolte KB, Brass LM, Fletterick CF (1996) Intracranial hemorrhage associated with cocaine abuse: a prospective autopsy study. Neurology 46:1291–1296

    CAS  PubMed  Google Scholar 

  92. Buttner A, Mall G, Penning R, Sachs H, Weis S (2003) The neuropathology of cocaine abuse. Leg Med 5(Suppl 1):S240–242

    CAS  Google Scholar 

  93. Cohen JE, Eger K, Montero A, Israel Z (1998) Rapid spontaneous resolution of acute subdural hematoma and HIV related cerebral atrophy: case report. Surg Neurol 50:241–244

    CAS  PubMed  Google Scholar 

  94. Jordan BD, Navia BA, Petito C et al (1985) Neurological syndromes complicating AIDS. Front Radiat Ther Oncol 19:82–87

    CAS  PubMed  Google Scholar 

  95. Meyohas MC, Roullet E, Rouzioux C et al (1989) Cerebral venous thrombosis and dual primary infection with human immunodeficiency virus and cytomegalovirus. J Neurol Neurosurg Psychiatry 52:1010–1011

    CAS  PubMed  Google Scholar 

  96. Doberson MJ, Kleinschmidt-DeMasters BK (1994) Superior sagittal sinus thrombosis in a patient with acquired immunodeficiency syndrome. Arch Pathol Lab Med 118:844–846

    CAS  PubMed  Google Scholar 

  97. Iranzo A, Domingo P, Cadafalch J, Sambeat MA (1998) Intracranial venous and dural sinus thrombosis due to protein S deficiency in a patient with AIDS. J Neurol Neurosurg Psychiatry 64:688

    CAS  PubMed  Google Scholar 

  98. Berger JR, Harris JO, Gregorios J, Norenberg M (1990) Cerebrovascular disease in AIDS: a case control study. AIDS 4:239–244

    CAS  PubMed  Google Scholar 

  99. Afsari K, Frank J, Vaksman Y, Nguyen TV (2003) Intracranial venous sinus thrombosis complicating AIDS-associated nephropathy. AIDS Read 13:143–148

    PubMed  Google Scholar 

  100. Spiegel M, Schmidauer C, Kampfl A, Sarcletti M, Poewe W (2001) Cerebral ergotism under treatment with ergotamine and ritonavir. Neurology 57:743–744

    CAS  PubMed  Google Scholar 

  101. Martinez E, Collazos J, Mayo J (1998) Shock and cerebral infarct after rifampicin re-exposure in a patient infected with human immunodeficiency virus. Clin Infect Dis 27:1329–1330

    CAS  PubMed  Google Scholar 

  102. Carvalho Felicio A, Sampaio G, Celso dos Santos WA et al (2006) Spontaneous artery dissection in a patient with human immunodeficiency virus infection. Arq Neuropsiquitr 64:306–308

    Google Scholar 

  103. Fénelon G, Gray F, Scaravilli F et al (1991) Ischemic myelopathy secondary to disseminated intravascular coagulation in AIDS. J Neurol 238:51–54

    PubMed  Google Scholar 

  104. Gray F, Belec L, Lescs MC (1994) Varicella-zoster virus infection of the central nervous system in the acquired immune deficiency syndrome. Brain 117:987–999

    PubMed  Google Scholar 

  105. Kenyon LC, Dulaney E, Montone KT et al (1996) Varicella-zoster ventriculo-encephalitis and spinal cord infarction in a patient with AIDS. Acta Neuropathol 92:202–205

    CAS  PubMed  Google Scholar 

  106. Park YD, Belman AL, Kim TS et al (1990) Stroke in pediatric acquired immunodeficiency syndrome. Ann Neurol 28:303–311

    CAS  PubMed  Google Scholar 

  107. Patsalides AD, Wood LV, Atac GK et al (2002) Cerebrovascular disease in HIV-infected pediatric patients: neuroimaging findings. Am J Roentgenol 179:999–1003

    Google Scholar 

  108. Visudtibhan A, Visudhiphan P, Chiemchanya S (1999) Stroke and seizures as the presenting signs of pediatric HIV infection. Pediatr Neurol 20:53–56

    CAS  PubMed  Google Scholar 

  109. Husson RN, Saini R, Lewis LL et al (1992) Cerebral artery aneurysms in children infected with human immunodeficiency virus. J Pediatr 121:927–930

    CAS  PubMed  Google Scholar 

  110. Kure K, Llena JF, Lyman WD et al (1991) Human immunodeficiency virus-1 infection of the nervous system: an autopsy study of 268 adult, pediatric, and fetal brains. Hum Pathol 22:700–710

    CAS  PubMed  Google Scholar 

  111. Lang C, Jacobi G, Kreuz W et al (1992) Rapid development of giant aneurysm at the base of the brain in an 8-year-old boy with perinatal HIV infection. Acta Histochem (Suppl) 42:83–90

    CAS  Google Scholar 

  112. Bonnet D, Aggoun Y, Szezepanski I et al (2004) Arterial stiffness and endothelial dysfunction in HIV-infected children. AIDS 18:1037–1041

    PubMed  Google Scholar 

  113. Mazzoni P, Chiriboga CA, Millar WS, Rogers A (2000) Intracerebral aneurysms in human immunodeficiency virus infection: case report and literature review. Pediatr Neurol 23:252–255

    CAS  PubMed  Google Scholar 

  114. McComsey GA, O’Riordan MA, Hazen SL et al (2007) Increased carotid intima media thickness and cardiac biomarkers in HIV infected children. AIDS 21:921–927

    PubMed  Google Scholar 

  115. Vilaseca MA, Sierra C, Colome C et al (2001) Hyperhomocysteinaemia and folate deficiency in human immunodeficiency virus-infected children. Eur J Clin Invest 31:992–998

    CAS  PubMed  Google Scholar 

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Moulignier, A. (2009). Cerebrovascular Disease in HIV-Infected Patients. In: Barbaro, G., Boccara, F. (eds) Cardiovascular Disease in AIDS. Springer, Milano. https://doi.org/10.1007/978-88-470-0761-1_10

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