New Insights into Prenatal Stress: Immediate and Long-Term Effects on the Fetus and Their Timing

  • K. O’Donnell
  • V. Glover


A burgeoning literature emphasizes the importance of the in-utero environment on a range of fetal, neonatal, infant and adult health-related outcomes. This period of prenatal development, characterized by rapid growth and development, is a time of increased vulnerability, when intrauterine insults can have deleterious effects on emerging systems and structures. One important factor which affects the in-utero environment is maternal stress.


Prenatal Stress Maternal Stress Acad Child Adolesc Psychiatry Mental Developmental Index Prenatal Maternal Stress 
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  1. 1.
    Giannakoulopoulos X, Sepulveda W, Kourtis P et al (1994) Fetal plasma cortisol and betaendorphin response to intrauterine needling. Lancet 344:77–81PubMedCrossRefGoogle Scholar
  2. 2.
    Gitau R, Fisk NM, Teixeira JM et al (2001) Fetal hypothalamic-pituitary-adrenal stress responses to invasive procedures are independent of maternal responses. J Clin Endocrinol Metab 86:104–109PubMedCrossRefGoogle Scholar
  3. 3.
    Giannakoulopoulos X, Teixeira J, Fisk N et al (1999) Human fetal and maternal noradrenaline responses to invasive procedures. Pediatr Res 45:494–499PubMedCrossRefGoogle Scholar
  4. 4.
    Teixeira JM, Glover V, Fisk NM (1999) Acute cerebral redistribution in response to invasive procedures in the human fetus. Am J Obstet Gynecol 181:1018–1025PubMedCrossRefGoogle Scholar
  5. 5.
    Smith RP, Glover V, Fisk NM (2003) Acute increase in femoral artery resistance in response to direct physical stimuli in the human fetus. BJOG 110:916–921PubMedCrossRefGoogle Scholar
  6. 6.
    Glover V, Fisk N (1996) Do fetuses feel pain? We don’t know; better to err on the safe side from mid-gestation. BMJ 313:796PubMedGoogle Scholar
  7. 7.
    Greenfield SA (1995) Journeys to the centres of the mind. Freeman, New YorkGoogle Scholar
  8. 8.
    Edelman DB, Tononi G (2000) A universe of conciousness. Basic Books, New YorkGoogle Scholar
  9. 9.
    Seth AK, Baars BJ, Edelman DB (2005) Criteria for consciousness in humans and other mammals. Conscious Cogn 14:119–139PubMedCrossRefGoogle Scholar
  10. 10.
    Edelman DB, Baars BJ, Seth AK (2005) Identifying hallmarks of consciousness in nonmammalian species. Conscious Cogn 14:169–187PubMedCrossRefGoogle Scholar
  11. 11.
    Lorenz J, Casey KL (2005) Imaging of acute versus pathological pain in humans. Eur J Pain 9:163–165PubMedCrossRefGoogle Scholar
  12. 12.
    Fitzgerald M (1994) Neurobiology of fetal and neonatal pain. In: Wall P, Melzack ER (eds) Textbook of pain. Churchill Livingstone, EdinburghGoogle Scholar
  13. 13.
    Klimach VJ, Cooke RW (1988) Maturation of the neonatal somatosensory evoked response in preterm infants. Dev Med Child Neurol 30:208–214PubMedCrossRefGoogle Scholar
  14. 14.
    Fitzgerald M (1993) Development of pain pathways and mechanisms. In: Anand KIS, McGrath PJ (eds) Pain research and clinical management. Elsevier, New YorkGoogle Scholar
  15. 15.
    Lee SJ, Ralston HJP, Drey EA et al (2005) Fetal pain: a systematic multidisciplinary review of the evidence. JAMA 294:947–954PubMedCrossRefGoogle Scholar
  16. 16.
    Austin MP, Leader LR, Reilly N (2005) Prenatal stress, the hypothalamic-pituitary-adrenal axis, and fetal and infant neurobehaviour. Early Hum Dev 81:917–926PubMedCrossRefGoogle Scholar
  17. 17.
    Morishima HO, Pedersen H, Finster M (1978) The influence of maternal psychological stress on the fetus. Am J Obstet Gynecol 131:286–290PubMedGoogle Scholar
  18. 18.
    Myers RE (1975) Maternal psychological stress and fetal asphyxia: a study in the monkey. Am J Obstet Gynecol 122:47–59PubMedGoogle Scholar
  19. 19.
    DiPietro JA, Hilton SC, Hawkins M et al (2002) Maternal stress and affect influence fetal neurobehavioral development. Dev Psychol 38:659–668PubMedCrossRefGoogle Scholar
  20. 20.
    Monk C, Sloan RP, Myers MM et al (2004) Fetal heart rate reactivity differs by women’s psychiatric status: an early marker for developmental risk? J Am Acad Child Adolesc Psychiatry 43:283–290PubMedCrossRefGoogle Scholar
  21. 21.
    DiPietro JA, Costigan KA, Gurewitsch ED (2005) Maternal psychophysiological change during the second half of gestation. Biol Psychol 69:23–38PubMedCrossRefGoogle Scholar
  22. 22.
    Kammerer M, Adams D, Castelberg Bv, Glover V (2002) Pregnant women become insensitive to cold stress. BMC Pregnancy Childbirth 2:8PubMedCrossRefGoogle Scholar
  23. 23.
    Barker DJ, Osmond C (1986) Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet 1:1077–1081PubMedCrossRefGoogle Scholar
  24. 24.
    Osmond C, Barker DJ, Winter PD et al (1993) Early growth and death from cardiovascular disease in women. BMJ 307:1519–1524PubMedCrossRefGoogle Scholar
  25. 25.
    Van den Bergh BR, Mulder EJ, Mennes M et al (2005) Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review. Neurosci Biobehav Rev 29:237–258CrossRefGoogle Scholar
  26. 26.
    Talge NM, Neal C, Glover V (2007) Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? J Child Psychol Psychiatry 48:245–261PubMedCrossRefGoogle Scholar
  27. 27.
    O’Connor TG, Heron J, Golding J et al (2002) Maternal antenatal anxiety and children’s behavioural/emotional problems at 4 years. Report from the Avon Longitudinal Study of Parents and Children. Br J Psychiatry 180:502–508PubMedCrossRefGoogle Scholar
  28. 28.
    van den Bergh BR, Mennes M, Stevens V et al (2006) ADHD deficit as measured in adolescent boys with a continuous performance task is related to antenatal maternal anxiety. Pediatr Res 59:78–82PubMedCrossRefGoogle Scholar
  29. 29.
    Van den Bergh BR, Marcoen A (2004) High antenatal maternal anxiety is related to ADHD symptoms, externalizing problems, and anxiety in 8-and 9-year-olds. Child Dev 75:1085–1097PubMedCrossRefGoogle Scholar
  30. 30.
    Niederhofer H, Reiter A (2004) Prenatal maternal stress, prenatal fetal movements and perinatal temperament factors influence behavior and school marks at the age of 6 years. Fetal Diagn Ther 19:160–162PubMedCrossRefGoogle Scholar
  31. 31.
    Huizink AC, Robles de Medina PG, Mulder EJ et al (2003) Stress during pregnancy is associated with developmental outcome in infancy. J Child Psychol Psychiatry 44:810–818PubMedCrossRefGoogle Scholar
  32. 32.
    Bergman K, Sarkar P, O’Connor TG et al (2007) Maternal stress during pregnancy predicts cognitive ability and fearfulness in infancy. J Am Acad Child Adolesc Psychiatry (in press)Google Scholar
  33. 33.
    Laplante DP, Barr RG, Brunet A et al (2004) Stress during pregnancy affects general intellectual and language functioning in human toddlers. Pediatr Res 56:400–410PubMedCrossRefGoogle Scholar
  34. 34.
    DiPietro JA, Novak MF, Costigan KA et al (2006) Maternal psychological distress during pregnancy in relation to child development at age two. Child Dev 77:573–587PubMedCrossRefGoogle Scholar
  35. 35.
    van Os J, Selten JP (1998) Prenatal exposure to maternal stress and subsequent schizophrenia. The May 1940 invasion of The Netherlands. Br J Psychiatry 172:324–326PubMedGoogle Scholar
  36. 36.
    Selten JP, van der Graaf Y, van Duursen R et al (1999) Psychotic illness after prenatal exposure to the 1953 Dutch Flood Disaster. Schizophr Res 35:243–245PubMedCrossRefGoogle Scholar
  37. 37.
    Brown AS, Susser ES, Lin SP et al (1995) Increased risk of affective disorders in males after second trimester prenatal exposure to the Dutch hunger winter of 1944-45. Br J Psychiatry 166:601–606PubMedGoogle Scholar
  38. 38.
    Brown AS, van Os J, Driessens C et al (2000) Further evidence of relation between prenatal famine and major affective disorder. Am J Psychiatry 157:190–195PubMedCrossRefGoogle Scholar
  39. 39.
    Weinstock M (1997) Does prenatal stress impair coping and regulation of hypothalamic-pituitary-adrenal axis? Neurosci Biobehav Rev 21:1–10PubMedCrossRefGoogle Scholar
  40. 40.
    Schneider ML, Coe CL, Lubach GR (1992) Endocrine activation mimics the adverse effects of prenatal stress on the neuromotor development of the infant primate. Dev Psychobiol 25:427–439PubMedCrossRefGoogle Scholar
  41. 41.
    Schneider ML, Moore CF, Kraemer GW et al (2002) The impact of prenatal stress, fetal alcohol exposure, or both on development: perspectives from a primate model. Psychoneuroendocrinology 27:285–298PubMedCrossRefGoogle Scholar
  42. 42.
    Schneider ML (1999) Growth and development following prenatal stress exposure in primates: an examination of ontogenetic vulnerability. Child Dev 70:263PubMedCrossRefGoogle Scholar
  43. 43.
    O’Connor TG, Ben-Shlomo Y, Heron J et al (2005) Prenatal anxiety predicts individual differences in cortisol in pre-adolescent children. Biol Psychiatry 58:211–217PubMedCrossRefGoogle Scholar
  44. 44.
    Gitau R, Cameron A, Fisk NM et al (1998) Fetal exposure to maternal cortisol. Lancet 352:707–708PubMedCrossRefGoogle Scholar
  45. 45.
    Sarkar P, Bergman K, Fisk NM et al (2007) Ontogeny of foetal exposure to maternal cortisol using midtrimester amniotic fluid as a biomarker. Clin Endocrinol (Oxf) 66:636–640CrossRefGoogle Scholar
  46. 46.
    Schulte HM, Weisner D, Allolio B (1990) The corticotrophin releasing hormone test in late pregnancy: lack of adrenocorticotrophin and cortisol response. Clin Endocrinol (Oxf) 33:99–106Google Scholar
  47. 47.
    Sarkar P, Bergman K, Fisk NM et al (2006) Maternal anxiety at amniocentesis and plasma cortisol. Prenat Diagn 26:505–509PubMedCrossRefGoogle Scholar
  48. 48.
    Mairesse J, Lesage J, Breton C et al (2007) Maternal stress alters endocrine function of the feto-placental unit in rats. Am J Physiol Endocrinol Metab 292:E1526–E1533PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • K. O’Donnell
    • 1
  • V. Glover
    • 1
  1. 1.Institute of Reproductive and Developmental BiologyImperial College LondonLondonUK

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