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Pharmacologic Analgesia in the Newborn

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Neonatal Pain

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Abstract

There is increasing evidence that neuroanatomic and neuroendocrine components for the perception and transmission of painful stimuli are fully developed in the newborn even when preterm. Incomplete myelination only means slower transmission. Pain in the newborn increases heart rate, mean airway pressure, O2 consumption, and levels of catecholamines, corticosteroids, and glucagons; decreases arterial O2 saturation; produces acidosis, hyperglycemia, and pulmonary hypertension; and increases susceptibility to infections and intraventricular hemorrhage (preterms) [1, 2]. Untreated pain may in fact exacerbate injury, increase the incidence of neurological handicap, lead to infection, prolong hospitalization, and may even lead to death [3, 4].

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Authors and Affiliations

  1. Department of Medical and Surgical Neonatology, Bambin Gesù Pediatric Hospital - I.R.C.C.S. - Roma, Italy

    A. M. Guadagni

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  1. A. M. Guadagni
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Editors and Affiliations

  1. Department of Pediatrics, Obstetrics and Reproduction Medicine, University of Siena, Siena, Italy

    Giuseppe Buonocore  & Carlo V. Bellieni  & 

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Guadagni, A.M. (2008). Pharmacologic Analgesia in the Newborn. In: Buonocore, G., Bellieni, C.V. (eds) Neonatal Pain. Springer, Milano. https://doi.org/10.1007/978-88-470-0732-1_13

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  • DOI: https://doi.org/10.1007/978-88-470-0732-1_13

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0731-4

  • Online ISBN: 978-88-470-0732-1

  • eBook Packages: MedicineMedicine (R0)

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