Neonatal Pain pp 103-108 | Cite as

Pharmacologic Analgesia in the Newborn

  • A. M. Guadagni


There is increasing evidence that neuroanatomic and neuroendocrine components for the perception and transmission of painful stimuli are fully developed in the newborn even when preterm. Incomplete myelination only means slower transmission. Pain in the newborn increases heart rate, mean airway pressure, O2 consumption, and levels of catecholamines, corticosteroids, and glucagons; decreases arterial O2 saturation; produces acidosis, hyperglycemia, and pulmonary hypertension; and increases susceptibility to infections and intraventricular hemorrhage (preterms) [1, 2]. Untreated pain may in fact exacerbate injury, increase the incidence of neurological handicap, lead to infection, prolong hospitalization, and may even lead to death [3, 4].


Epidural Infusion Heel Prick Heel Lance Neuroendocrine Component Neonatal Pain 
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Copyright information

© Springer 2008

Authors and Affiliations

  • A. M. Guadagni
    • 1
  1. 1.Department of Medical and Surgical NeonatologyBambin Gesù Pediatric Hospital - I.R.C.C.S. - RomaItaly

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