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Abstract

Curative treatment of hilar cholangiocarcinoma leads to a major reduction of hepatic function due to the need for extended hepatectomy with biliary tract resection; therefore, it is exposed to the risk of postoperative hepatic failure [1,2]. Makuuchi [3] can take the credit, for introducing preoperative embolic occlusion of portal branches (PVE) in patients with hilar cholangiocarcinoma to stimulate compensatory hypertrophy of the future remnant liver (FRL) and prevent the sudden increase of portal pressure after hepatectomy. Diversion of portal flow following PVE entails an improvement of the functional reserve of residual liver and allows extending the indications for surgical therapy even in patients with a marginal hepatic function.

Keywords

Hepatic Resection Portal Vein Embolization Hilar Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Portal Branch 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Shirabe K, Shimada M, Gion T et al (1999) Postoperative liver failure after major hepatic resection for hepatocellular carcinoma in the modern era with special reference to remnant liver volume. J Am Coll Surg 188(3):304–309PubMedCrossRefGoogle Scholar
  2. 2.
    Abdalla EK, Barnett CC, Doherty D et al (2002) Extended hepatectomy in patients with hepatobiliary malignancies with and without preoperative portal vein embolization. Arch Surg 137(6):675–680; discussion 680–681PubMedCrossRefGoogle Scholar
  3. 3.
    Makuuchi M, Thai BL, Takayasu K et al (1990) Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report. Surgery 107(5):521–527PubMedGoogle Scholar
  4. 4.
    Black DM, Behrns KE (2002) A scientist revisits the atrophy-hypertrophy complex: hepatic apoptosis and regeneration. Surg Oncol Clin N Am 11(4):849–864PubMedCrossRefGoogle Scholar
  5. 5.
    Yokoyama Y, Nagino M, Nimura Y (2007) Mechanisms of hepatic regeneration following portal vein embolization and partial hepatectomy: a review. World J Surg 31(2):367–374PubMedCrossRefGoogle Scholar
  6. 6.
    Komori K, Nagino M, Nimura Y (2006) Hepatocyte morphology and kinetics after portal vein embolization. Br J Surg 93(6):745–751PubMedCrossRefGoogle Scholar
  7. 7.
    Madoff DC, Abdalla EK, Vauthey JN (2005) Portal vein embolization in preparation for major hepatic resection: evolution of a new standard of care. J Vasc Interv Radiol 16(6):779–790PubMedGoogle Scholar
  8. 8.
    Nagino M, Nimura Y, Kamiya J (1995) Changes in hepatic lobe volume in biliary tract cancer patients after right portal vein embolization. Hepatology 21(2):434–439PubMedGoogle Scholar
  9. 9.
    Abdalla EK, Hicks ME, Vauthey JN (2001) Portal vein embolization: rationale, technique and future prospects. Br J Surg 88(2):165–175PubMedCrossRefGoogle Scholar
  10. 10.
    Goto Y, Nagino M, Nimura Y (1998) Doppler estimation of portal blood flow after percutaneous transhepatic portal vein embolization. Ann Surg 228(2):209–213PubMedCrossRefGoogle Scholar
  11. 11.
    Hemming AW, Reed AI, Howard RJ et al (2003) Preoperative portal vein embolization for extended hepatectomy. Ann Surg 237(5):686–691: discussion 691–693PubMedCrossRefGoogle Scholar
  12. 12.
    Yigitler C, Farges O, Kianmanesh R et al (2003) The small remnant liver after major liver resection: how common and how relevant? Liver Transpl 9(9):S18–S25PubMedCrossRefGoogle Scholar
  13. 13.
    Vauthey JN, Chaoui A, Do KA et al (2000) Standardized measurement of the future liver remnant prior to extended liver resection: methodology and clinical associations. Surgery 127(5):512–519PubMedCrossRefGoogle Scholar
  14. 14.
    Kubota K, Makuuchi M, Kusaka K et al (1997) Measurement of liver volume and hepatic functional reserve as a guide to decision-making in resectional surgery for hepatic tumours. Hepatology 26(5):1176–1181PubMedGoogle Scholar
  15. 15.
    Azoulay D, Castaing D, Krissat J et al (2000) Percutaneous portal vein embolization increases the feasibility and safety of major liver resection for hepatocellular carcinoma in injured liver. Ann Surg 232(5):665–672PubMedCrossRefGoogle Scholar
  16. 16.
    Farges O, Belghiti J, Kianmanesh R et al (2003) Portal vein embolization before right hepatectomy: prospective clinical trial. Ann Surg 237(2):208–217PubMedCrossRefGoogle Scholar
  17. 17.
    Belghiti J (2004) Arguments for a selective approach of preoperative portal vein embolization before major hepatic resection. J Hepatobiliary Pancreat Surg 11(1):21–24PubMedCrossRefGoogle Scholar
  18. 18.
    Imamura H, Shimada R, Kubota M et al (1999) Preoperative portal vein embolization: an audit of 84 patients. Hepatology 29(4):1099–1105PubMedCrossRefGoogle Scholar
  19. 19.
    Cherqui D, Benoist S, Malassagne B et al (2000) Major liver resection for carcinoma in jaundiced patients without preoperative biliary drainage. Arch Surg 135(3):302–308PubMedCrossRefGoogle Scholar
  20. 20.
    Nagino M, Nimura Y, Hayakawa N (1993) Percutaneous transhepatic portal embolization using newly devised catheters: preliminary report. World J Surg 17(4):520–524PubMedCrossRefGoogle Scholar
  21. 21.
    Nagino M, Kamiya J, Nishio H et al (2006) Two hundred forty consecutive portal vein embolizations before extended hepatectomy for biliary cancer: surgical outcome and longterm follow-up. Ann Surg 243(3):364–372PubMedCrossRefGoogle Scholar
  22. 22.
    Denys AL, Abehsera M, Sauvanet A et al (1999) Failure of right portal vein ligation to induce left lobe hypertrophy due to intrahepatic portoportal collaterals: successful treatment with portal vein embolization. AJR Am J Roentgenol 173(3):633–635PubMedGoogle Scholar
  23. 23.
    Kinoshita H, Sakai K, Hirohashi K et al (1986) Preoperative portal vein embolization for hepatocellular carcinoma. World J Surg 10(5):803–808PubMedCrossRefGoogle Scholar
  24. 24.
    Di Stefano DR, de Baere T, Denys A et al (2005) Preoperative percutaneous portal vein embolization: evaluation of adverse events in 188 patients. Radiology 234(2):625–630PubMedCrossRefGoogle Scholar
  25. 25.
    Nagino M, Nimura Y, Kamiya J et al (1996) Selective percutaneous transhepatic embolization of the portal vein in preparation for extensive liver resection: the ipsilateral approach. Radiology 200(2):559–563PubMedGoogle Scholar
  26. 26.
    Madoff DC, Hicks ME, Abdalla EK et al (2003) Portal vein embolization with polyvinyl alcohol particles and coils in preparation for major liver resection for hepatobiliary malignancy: safety and effectiveness study in 26 patients. Radiology 227(1):251–260PubMedCrossRefGoogle Scholar
  27. 27.
    Liem MS, Liu CL, Tso WK et al (2005) Portal vein embolisation prior to extended right-sided hepatic resection. Hong Kong Med J 11(5):366–372PubMedGoogle Scholar
  28. 28.
    Perarnau JM, Daradkeh S, Johann M et al (2003) Transjugular preoperative portal embolization (TJPE) a pilot study. Hepatogastroenterology 50(51):610–613PubMedGoogle Scholar
  29. 29.
    Bruix J, Castells A, Bosch J et al (1996) Surgical resection of hepatocellular carcinoma in cirrhotic patients: prognostic value of preoperative portal pressure. Gastroenterology 111(4):1018–1022PubMedCrossRefGoogle Scholar
  30. 30.
    Tanaka H, Hirohashi K, Kubo S et al (1999) Influence of histological inflammatory activity on regenerative capacity of liver after percutaneous transhepatic portal vein embolization. J Gastroenterol 34(1):100–104PubMedCrossRefGoogle Scholar
  31. 31.
    Seyama Y, Kubota K, Sano K et al (2003) Long-term outcome of extended hemihepatectomy for hilar bile duct cancer with no mortality and high survival rate. Ann Surg 238(1):73–83PubMedCrossRefGoogle Scholar
  32. 32.
    Kodama Y, Shimizu T, Endo H et al (2002) Complications of percutaneous trnashepatic portal vein embolization. J Vasc Interv Radiol 13(12):1233–1237PubMedCrossRefGoogle Scholar
  33. 33.
    Lee KC, Kinoshita H, Hirohashi K et al (1993) Extension of surgical indications for hepatocellular carcinoma by portal vein embolization. World J Surg 17(1):109–115PubMedCrossRefGoogle Scholar
  34. 34.
    Shimamura T, Nakajima Y, Une Y et al (1997) Efficacy and safety of preoperative percutaneous transhepatic portal embolization with absolute ethanol: a clinical study. Surgery 121(2):135–141PubMedCrossRefGoogle Scholar
  35. 35.
    Wakabayashi H, Yachida S, Maeba T, Maeta H (2000) Indications for portal vein embolization combined with major hepatic resection for advanced-stage hepatocellular carcinomas. A preliminary clinical study. Dig Surg 17(6):587–594PubMedCrossRefGoogle Scholar
  36. 36.
    Tanaka H, Hirohashi K, Kubo S et al (2000) Preoperative portal vein embolization improves prognosis after right hepatectomy for hepatocellular carcinoma in patients with impaired hepatic function. Br J Surg 87(7):879–882PubMedCrossRefGoogle Scholar

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