Skip to main content

Preoperative Portal Vein Embolization

  • Chapter
  • First Online:
Surgical Treatment of Hilar and Intrahepatic Cholangiocarcinoma

Part of the book series: Updates in Surgery ((UPDATESSURG))

  • 800 Accesses

Abstract

Curative treatment of hilar cholangiocarcinoma leads to a major reduction of hepatic function due to the need for extended hepatectomy with biliary tract resection; therefore, it is exposed to the risk of postoperative hepatic failure [1,2]. Makuuchi [3] can take the credit, for introducing preoperative embolic occlusion of portal branches (PVE) in patients with hilar cholangiocarcinoma to stimulate compensatory hypertrophy of the future remnant liver (FRL) and prevent the sudden increase of portal pressure after hepatectomy. Diversion of portal flow following PVE entails an improvement of the functional reserve of residual liver and allows extending the indications for surgical therapy even in patients with a marginal hepatic function.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Shirabe K, Shimada M, Gion T et al (1999) Postoperative liver failure after major hepatic resection for hepatocellular carcinoma in the modern era with special reference to remnant liver volume. J Am Coll Surg 188(3):304–309

    Article  CAS  PubMed  Google Scholar 

  2. Abdalla EK, Barnett CC, Doherty D et al (2002) Extended hepatectomy in patients with hepatobiliary malignancies with and without preoperative portal vein embolization. Arch Surg 137(6):675–680; discussion 680–681

    Article  PubMed  Google Scholar 

  3. Makuuchi M, Thai BL, Takayasu K et al (1990) Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report. Surgery 107(5):521–527

    CAS  PubMed  Google Scholar 

  4. Black DM, Behrns KE (2002) A scientist revisits the atrophy-hypertrophy complex: hepatic apoptosis and regeneration. Surg Oncol Clin N Am 11(4):849–864

    Article  PubMed  Google Scholar 

  5. Yokoyama Y, Nagino M, Nimura Y (2007) Mechanisms of hepatic regeneration following portal vein embolization and partial hepatectomy: a review. World J Surg 31(2):367–374

    Article  CAS  PubMed  Google Scholar 

  6. Komori K, Nagino M, Nimura Y (2006) Hepatocyte morphology and kinetics after portal vein embolization. Br J Surg 93(6):745–751

    Article  CAS  PubMed  Google Scholar 

  7. Madoff DC, Abdalla EK, Vauthey JN (2005) Portal vein embolization in preparation for major hepatic resection: evolution of a new standard of care. J Vasc Interv Radiol 16(6):779–790

    Article  PubMed  Google Scholar 

  8. Nagino M, Nimura Y, Kamiya J (1995) Changes in hepatic lobe volume in biliary tract cancer patients after right portal vein embolization. Hepatology 21(2):434–439

    CAS  PubMed  Google Scholar 

  9. Abdalla EK, Hicks ME, Vauthey JN (2001) Portal vein embolization: rationale, technique and future prospects. Br J Surg 88(2):165–175

    Article  CAS  PubMed  Google Scholar 

  10. Goto Y, Nagino M, Nimura Y (1998) Doppler estimation of portal blood flow after percutaneous transhepatic portal vein embolization. Ann Surg 228(2):209–213

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hemming AW, Reed AI, Howard RJ et al (2003) Preoperative portal vein embolization for extended hepatectomy. Ann Surg 237(5):686–691: discussion 691–693

    PubMed  PubMed Central  Google Scholar 

  12. Yigitler C, Farges O, Kianmanesh R et al (2003) The small remnant liver after major liver resection: how common and how relevant? Liver Transpl 9(9):S18–S25

    Article  PubMed  Google Scholar 

  13. Vauthey JN, Chaoui A, Do KA et al (2000) Standardized measurement of the future liver remnant prior to extended liver resection: methodology and clinical associations. Surgery 127(5):512–519

    Article  CAS  PubMed  Google Scholar 

  14. Kubota K, Makuuchi M, Kusaka K et al (1997) Measurement of liver volume and hepatic functional reserve as a guide to decision-making in resectional surgery for hepatic tumours. Hepatology 26(5):1176–1181

    CAS  PubMed  Google Scholar 

  15. Azoulay D, Castaing D, Krissat J et al (2000) Percutaneous portal vein embolization increases the feasibility and safety of major liver resection for hepatocellular carcinoma in injured liver. Ann Surg 232(5):665–672

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Farges O, Belghiti J, Kianmanesh R et al (2003) Portal vein embolization before right hepatectomy: prospective clinical trial. Ann Surg 237(2):208–217

    PubMed  PubMed Central  Google Scholar 

  17. Belghiti J (2004) Arguments for a selective approach of preoperative portal vein embolization before major hepatic resection. J Hepatobiliary Pancreat Surg 11(1):21–24

    Article  PubMed  Google Scholar 

  18. Imamura H, Shimada R, Kubota M et al (1999) Preoperative portal vein embolization: an audit of 84 patients. Hepatology 29(4):1099–1105

    Article  CAS  PubMed  Google Scholar 

  19. Cherqui D, Benoist S, Malassagne B et al (2000) Major liver resection for carcinoma in jaundiced patients without preoperative biliary drainage. Arch Surg 135(3):302–308

    Article  CAS  PubMed  Google Scholar 

  20. Nagino M, Nimura Y, Hayakawa N (1993) Percutaneous transhepatic portal embolization using newly devised catheters: preliminary report. World J Surg 17(4):520–524

    Article  CAS  PubMed  Google Scholar 

  21. Nagino M, Kamiya J, Nishio H et al (2006) Two hundred forty consecutive portal vein embolizations before extended hepatectomy for biliary cancer: surgical outcome and longterm follow-up. Ann Surg 243(3):364–372

    Article  PubMed  PubMed Central  Google Scholar 

  22. Denys AL, Abehsera M, Sauvanet A et al (1999) Failure of right portal vein ligation to induce left lobe hypertrophy due to intrahepatic portoportal collaterals: successful treatment with portal vein embolization. AJR Am J Roentgenol 173(3):633–635

    Article  CAS  PubMed  Google Scholar 

  23. Kinoshita H, Sakai K, Hirohashi K et al (1986) Preoperative portal vein embolization for hepatocellular carcinoma. World J Surg 10(5):803–808

    Article  CAS  PubMed  Google Scholar 

  24. Di Stefano DR, de Baere T, Denys A et al (2005) Preoperative percutaneous portal vein embolization: evaluation of adverse events in 188 patients. Radiology 234(2):625–630

    Article  PubMed  Google Scholar 

  25. Nagino M, Nimura Y, Kamiya J et al (1996) Selective percutaneous transhepatic embolization of the portal vein in preparation for extensive liver resection: the ipsilateral approach. Radiology 200(2):559–563

    Article  CAS  PubMed  Google Scholar 

  26. Madoff DC, Hicks ME, Abdalla EK et al (2003) Portal vein embolization with polyvinyl alcohol particles and coils in preparation for major liver resection for hepatobiliary malignancy: safety and effectiveness study in 26 patients. Radiology 227(1):251–260

    Article  PubMed  Google Scholar 

  27. Liem MS, Liu CL, Tso WK et al (2005) Portal vein embolisation prior to extended right-sided hepatic resection. Hong Kong Med J 11(5):366–372

    CAS  PubMed  Google Scholar 

  28. Perarnau JM, Daradkeh S, Johann M et al (2003) Transjugular preoperative portal embolization (TJPE) a pilot study. Hepatogastroenterology 50(51):610–613

    PubMed  Google Scholar 

  29. Bruix J, Castells A, Bosch J et al (1996) Surgical resection of hepatocellular carcinoma in cirrhotic patients: prognostic value of preoperative portal pressure. Gastroenterology 111(4):1018–1022

    Article  CAS  PubMed  Google Scholar 

  30. Tanaka H, Hirohashi K, Kubo S et al (1999) Influence of histological inflammatory activity on regenerative capacity of liver after percutaneous transhepatic portal vein embolization. J Gastroenterol 34(1):100–104

    Article  CAS  PubMed  Google Scholar 

  31. Seyama Y, Kubota K, Sano K et al (2003) Long-term outcome of extended hemihepatectomy for hilar bile duct cancer with no mortality and high survival rate. Ann Surg 238(1):73–83

    PubMed  PubMed Central  Google Scholar 

  32. Kodama Y, Shimizu T, Endo H et al (2002) Complications of percutaneous trnashepatic portal vein embolization. J Vasc Interv Radiol 13(12):1233–1237

    Article  PubMed  Google Scholar 

  33. Lee KC, Kinoshita H, Hirohashi K et al (1993) Extension of surgical indications for hepatocellular carcinoma by portal vein embolization. World J Surg 17(1):109–115

    Article  CAS  PubMed  Google Scholar 

  34. Shimamura T, Nakajima Y, Une Y et al (1997) Efficacy and safety of preoperative percutaneous transhepatic portal embolization with absolute ethanol: a clinical study. Surgery 121(2):135–141

    Article  CAS  PubMed  Google Scholar 

  35. Wakabayashi H, Yachida S, Maeba T, Maeta H (2000) Indications for portal vein embolization combined with major hepatic resection for advanced-stage hepatocellular carcinomas. A preliminary clinical study. Dig Surg 17(6):587–594

    Article  CAS  PubMed  Google Scholar 

  36. Tanaka H, Hirohashi K, Kubo S et al (2000) Preoperative portal vein embolization improves prognosis after right hepatectomy for hepatocellular carcinoma in patients with impaired hepatic function. Br J Surg 87(7):879–882

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer

About this chapter

Cite this chapter

Guglielmi, A., Ruzzenente, A., Iacono, C. (2008). Preoperative Portal Vein Embolization. In: Surgical Treatment of Hilar and Intrahepatic Cholangiocarcinoma. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-0729-1_7

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-0729-1_7

  • Published:

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0728-4

  • Online ISBN: 978-88-470-0729-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics