The main prognostic factors of intrahepatic cholangiocarcinoma (ICC) are: gross type (size, multifocality, vascular, serosal and biliary involvement), local extent, lymph-node involvement and microscopic and molecular biological patterns.


Biliary Tract Cancer Intrahepatic Cholangiocarcinoma Mass Form Intrahepatic Metastasis Serosal Invasion 
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  1. 1.
    The Liver Cancer Study Group of Japan (2003). General rules for the clinical and pathological study of primary liver cancer. 2nd edn. Kanehara, TokyoGoogle Scholar
  2. 2.
    Sasaki A, Aramaki M, Kawano K et al (1998) Intrahepatic peripheral cholangiocarcinoma: mode of spread and choice of surgical treatment. Br J Surg 85(9):1206–1209PubMedCrossRefGoogle Scholar
  3. 3.
    Yamamoto M, Takasaki K, Yoshikawa T (1999) Extended resection for intrahepatic cholangiocarcinoma in Japan. J Hepatobiliary Pancreat Surg 6(2):117–121PubMedCrossRefGoogle Scholar
  4. 4.
    Yamamoto M, Takasaki K, Yoshikawa T et al (1998) Does gross appearance indicate prognosis in intrahepatic cholangiocarcinoma? J Surg Oncol 69(3):162–167PubMedCrossRefGoogle Scholar
  5. 5.
    Suh KS, Roh HR, Koh YT et al (2000) Clinicopathologic features of the intraductal growth type of peripheral cholangiocarcinoma. Hepatology 31(1):12–17PubMedCrossRefGoogle Scholar
  6. 6.
    Ohashi K, Nakajima Y, Kanehiro H et al (1995) Ki-ras mutations and p53 protein expressions in intrahepatic cholangiocarcinomas: relation to gross tumour morphology. Gastroenterology 109(5):1612–1617PubMedCrossRefGoogle Scholar
  7. 7.
    Yeh CN, Jan YY, Yeh TS et al (2004) Hepatic resection of the intraductal papillary type of peripheral cholangiocarcinoma. Ann Surg Oncol 11(6):606–611PubMedCrossRefGoogle Scholar
  8. 8.
    Sakamoto E, Hayakawa N, Kamiya J et al (1999) Treatment strategy for mucin-producing intrahepatic cholangiocarcinoma: value of percutaneous transhepatic biliary drainage and cholangioscopy. World J Surg 23(10):1038–1043PubMedCrossRefGoogle Scholar
  9. 9.
    Isa T, Kusano T, Shimoji H et al (2001) Predictive factors for long-term survival in patients with intrahepatic cholangiocarcinoma. Am J Surg 181(6):507–511PubMedCrossRefGoogle Scholar
  10. 10.
    Ikai I, Arii S, Ichida T et al (2005) Report of the 16th follow-up survey of primary liver cancer. Hepatol Res 32(3):163–172PubMedCrossRefGoogle Scholar
  11. 11.
    Yamasaki S (2003) Intrahepatic cholangiocarcinoma: macroscopic type and stage classification. J Hepatobiliary Pancreat Surg 10(4):288–291PubMedCrossRefGoogle Scholar
  12. 12.
    Uenishi T, Yamazaki O, Yamamoto T et al (2005) Serosal invasion in TNM staging of mass-forming intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg 12(6):479–483PubMedCrossRefGoogle Scholar
  13. 13.
    Hirohashi K, Uenishi T, Kubo S et al (2002) Histologic bile duct invasion by a mass-forming intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg 9(2):233–236PubMedCrossRefGoogle Scholar
  14. 14.
    Morimoto Y, Tanaka Y, Ito T et al (2003) Long-term survival and prognostic factors in the surgical treatment for intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg 10(6):432–440PubMedCrossRefGoogle Scholar
  15. 15.
    Suzuki S, Sakaguchi T, Yokoi Y et al (2002) Clinicopathological prognostic factors and impact of surgical treatment of mass-forming intrahepatic cholangiocarcinoma. World J Surg 26(6):687–693PubMedCrossRefGoogle Scholar
  16. 16.
    Nozaki Y, Yamamoto M, Ikai I et al (1998) Reconsideration of the lymph-node metastasis pattern (N factor) from intrahepatic cholangiocarcinoma using the International Union Against Cancer TNM staging system for primary liver carcinoma. Cancer 83(9):1923–1929PubMedCrossRefGoogle Scholar
  17. 17.
    Isaji S, Kawarada Y, Taoka H et al (1999) Clinicopathological features and outcome of hepatic resection for intrahepatic cholangiocarcinoma in Japan. J Hepatobiliary Pancreat Surg 6(2):108–116PubMedCrossRefGoogle Scholar
  18. 18.
    Nakagawa T, Kamiyama T, Kurauchi N et al (2005) Number of lymph-node metastases is a significant prognostic factor in intrahepatic cholangiocarcinoma. World J Surg 29(6):728–733PubMedCrossRefGoogle Scholar
  19. 19.
    Miwa S, Miyagawa S, Kobayashi A et al (2006) Predictive factors for intrahepatic cholangiocarcinoma recurrence in the liver following surgery. J Gastroenterol 41(9):893–900PubMedCrossRefGoogle Scholar
  20. 20.
    Nakagohri T, Asano T, Kinoshita H et al (2003) Aggressive surgical resection for hilar-invasive and peripheral intrahepatic cholangiocarcinoma. World J Surg 27(3):289–293PubMedCrossRefGoogle Scholar
  21. 21.
    Nakajima T, Kondo Y, Miyazaki M, Okui K (1988) A histopathologic study of 102 cases of intrahepatic cholangiocarcinoma: histologic classification and modes of spreading. Hum Pathol 19(10):1228–1234PubMedCrossRefGoogle Scholar
  22. 22.
    Valverde A, Bonhomme N, Farges O et al (1999) Resection of intrahepatic cholangiocarcinoma: a Western experience. J Hepatobiliary Pancreat Surg 6(2):122–127PubMedCrossRefGoogle Scholar
  23. 23.
    Casavilla FA, Marsh JW, Iwatsuki S et al (1997) Hepatic resection and transplantation for peripheral cholangiocarcinoma. J Am Coll Surg 185(5):429–436PubMedGoogle Scholar
  24. 24.
    Okabayashi T, Yamamoto J, Kosuge T et al (2001) A new staging system for mass-forming intrahepatic cholangiocarcinoma: analysis of preoperative and postoperative variables. Cancer 92(9):2374–2383PubMedCrossRefGoogle Scholar
  25. 25.
    Lang H, Kaiser GM, Zopf T et al (2006) Surgical therapy of hilar cholangiocarcinoma. Chirurg 77(4):325–334PubMedCrossRefGoogle Scholar
  26. 26.
    Ohtsuka M, Ito H, Kimura F et al (2002) Results of surgical treatment for intrahepatic cholangiocarcinoma and clinicopathological factors influencing survival. Br J Surg 89(12):1525–1531PubMedCrossRefGoogle Scholar
  27. 27.
    Yamanaka N, Okamoto E, Ando T et al (1995) Clinicopathologic spectrum of resected extraductal mass-forming intrahepatic cholangiocarcinoma. Cancer 76(12):2449–2456PubMedCrossRefGoogle Scholar
  28. 28.
    Cherqui D, Tantawi B, Alon R et al (1995) Intrahepatic cholangiocarcinoma. Results of aggressive surgical management. Arch Surg 130(10):1073–1078PubMedGoogle Scholar
  29. 29.
    Yamamoto M, Takasaki K, Yoshikawa T (1999) Lymph-node metastasis in intrahepatic cholangiocarcinoma. Jpn J Clin Oncol 29(3):147–150PubMedCrossRefGoogle Scholar
  30. 30.
    Huang JL, Biehl TR, Lee FT et al (2004) Outcomes after resection of cholangiocellular carcinoma. Am J Surg 187(5):612–617PubMedCrossRefGoogle Scholar
  31. 31.
    Tsuji T, Hiraoka T, Kanemitsu K et al (2001) Lymphatic spreading pattern of intrahepatic cholangiocarcinoma. Surgery 129(4):401–407PubMedGoogle Scholar
  32. 32.
    Okami J, Dono K, Sakon M et al (2003) Patterns of regional lymph-node involvement in intrahepatic cholangiocarcinoma of the left lobe. J Gastrointest Surg 7(7):850–856PubMedCrossRefGoogle Scholar
  33. 33.
    Uenishi T, Hirohashi K, Kubo S et al (2001) Clinicopathological factors predicting outcome after resection of mass-forming intrahepatic cholangiocarcinoma. Br J Surg 88(7):969–974PubMedCrossRefGoogle Scholar
  34. 34.
    Abdalla EK, Vauthey JN (2001) Biliary tract cancer. Curr Opin Gastroenterol 17(5):450–457PubMedCrossRefGoogle Scholar
  35. 35.
    Rashid A, Ueki T, Gao YT et al (2002) K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China. Clin Cancer Res 8(10):3156–3163PubMedGoogle Scholar
  36. 36.
    Malhi H, Gores GJ (2006) Cholangiocarcinoma: modern advances in understanding a deadly old disease. J Hepatol 45(6):856–867PubMedCrossRefGoogle Scholar
  37. 37.
    Nakanuma Y, Harada K, Ishikawa A et al (2003) Anatomic and molecular pathology of intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg 10(4):265–281PubMedCrossRefGoogle Scholar
  38. 38.
    Park BK, Paik YH, Park JY et al (2006) The clinicopathologic significance of the expression of vascular endothelial growth factor-C in intrahepatic cholangiocarcinoma. Am J Clin Oncol 29(2):138–142PubMedCrossRefGoogle Scholar
  39. 39.
    Andrianifahanana M, Moniaux N, Batra SK (2006) Regulation of mucin expression: mechanistic aspects and implications for cancer and inflammatory diseases. Biochim Biophys Acta 1765(2):189–222PubMedGoogle Scholar

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