Long-term survival after surgery of hilar cholangiocarcinoma is related to patient status, tumour stage and proper treatment selection.


Portal Vein Embolisation Hilar Cholangiocarcinoma Bile Duct Cancer Intrahepatic Cholangiocarcinoma Preoperative Biliary Drainage 
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  1. 1.
    Mittal B, Deutsch M, Iwatsuki S (1985) Primary cancers of extrahepatic biliary passages. Int J Radiat Oncol Biol Phys 11(4):849–854PubMedGoogle Scholar
  2. 2.
    Seyama Y, Makuuchi M (2007) Current surgical treatment for bile duct cancer. World J Gastroenterol 13(10):1505–15PubMedGoogle Scholar
  3. 3.
    Sano T, Shimada K, Sakamoto Y et al (2006) One hundred two consecutive hepatobiliary resections for perihilar cholangiocarcinoma with zero mortality. Ann Surg 244(2):240–247PubMedCrossRefGoogle Scholar
  4. 4.
    Nagino M, Kamiya J, Arai T et al (2005) One hundred consecutive hepatobiliary resections for biliary hilar malignancy: preoperative blood donation, blood loss, transfusion, and outcome. Surgery 137(2):148–155PubMedCrossRefGoogle Scholar
  5. 5.
    Gerhards MF, van Gulik TM, de Wit LT et al (2000) Evaluation of morbidity and mortality after resection for hilar cholangiocarcinoma: a single center experience. Surgery 127(4):395–404PubMedCrossRefGoogle Scholar
  6. 6.
    Su CH, Tsay SH, Wu CC et al (1996) Factors influencing postoperative morbidity, mortality, and survival after resection for hilar cholangiocarcinoma. Ann Surg 223(4):384–394PubMedCrossRefGoogle Scholar
  7. 7.
    Cherqui D, Benoist S, Malassagne B et al (2000) Major liver resection for carcinoma in jaundiced patients without preoperative biliary drainage. Arch Surg 135(3):302–308PubMedCrossRefGoogle Scholar
  8. 8.
    Kanai M, Nimura Y, Kamiya J et al (1996) Preoperative intrahepatic segmental cholangitis in patients with advanced carcinoma involving the hepatic hilus. Surgery 119(5):498–504PubMedCrossRefGoogle Scholar
  9. 9.
    Klempnauer J, Ridder GJ, von Wasielewski R et al (1997) Resectional surgery of hilar cholangiocarcinoma: a multivariate analysis of prognostic factors. J Clin Oncol 15(3):947–954PubMedGoogle Scholar
  10. 10.
    Neuhaus P, Jonas S, Bechstein WO et al (1999) Extended resections for hilar cholangiocarcinoma. Ann Surg 230(6):808–818; discussion 819PubMedCrossRefGoogle Scholar
  11. 11.
    Miyazaki M, Ito H, Nakagawa K et al (1999) Parenchyma-preserving hepatectomy in the surgical treatment of hilar cholangiocarcinoma. J Am Coll Surg 189(6):575–583PubMedCrossRefGoogle Scholar
  12. 12.
    Kosuge T, Yamamoto J, Shimada K et al (1999) Improved surgical results for hilar cholangiocarcinoma with procedures including major hepatic resection. Ann Surg 230(5):663–671PubMedCrossRefGoogle Scholar
  13. 13.
    Dinant S, Gerhards MF, Rauws EA et al (2006) Improved outcome of resection of hilar cholangiocarcinoma (Klatskin tumour). Ann Surg Oncol 13(6):872–880PubMedCrossRefGoogle Scholar
  14. 14.
    Tabata M, Kawarada Y, Yokoi H et al (2000) Surgical treatment for hilar cholangiocarcinoma. J Hepatobiliary Pancreat Surg 7(2):148–154PubMedCrossRefGoogle Scholar
  15. 15.
    Lee SG, Lee YJ, Park KM et al (2000) One hundred and eleven liver resections for hilar bile duct cancer. J Hepatobiliary Pancreat Surg 7(2):135–141PubMedCrossRefGoogle Scholar
  16. 16.
    Seyama Y, Makuuchi M, Sano K et al (2002) Intermittent total vascular exclusion in removing caudate lobe tumour with tumour thrombus in the vena cava. Surgery 131(5):574–576PubMedCrossRefGoogle Scholar
  17. 17.
    Kawasaki S, Imamura H, Kobayashi A et al (2003) Results of surgical resection for patients with hilar bile duct cancer: application of extended hepatectomy after biliary drainage and hemihepatic portal vein embolization. Ann Surg 238(1):84–92PubMedCrossRefGoogle Scholar
  18. 18.
    Hemming AW, Reed AI, Fujita S et al (2005) Surgical management of hilar cholangiocarcinoma. Ann Surg 241(5):693–699: discussion 699–702PubMedCrossRefGoogle Scholar
  19. 19.
    Jarnagin WR, Fong Y, DeMatteo RP et al (2001) Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma. Ann Surg 234(4):507–517: discussion 517–519PubMedCrossRefGoogle Scholar
  20. 20.
    Fujii Y, Shimada H, Endo I et al (2003) Risk factors of posthepatectomy liver failure after portal vein embolization. J Hepatobiliary Pancreast Surg 10(3):226–232CrossRefGoogle Scholar
  21. 21.
    Nagino M, Kamiya J, Uesaka K et al (2001) Complications of hepatectomy for hilar cholangiocarcinoma. World J Surg 25(10):1277–1283PubMedCrossRefGoogle Scholar
  22. 22.
    Miyagawa S, Makuuchi M, Kawasaki S (1995) Outcome of extended right hepatectomy after biliary drainage in hilar bile duct cancer. Arch Surg 130(7):759–763PubMedGoogle Scholar
  23. 23.
    Pichlmayr R, Weimann A, Klempnauer J et al (1996) Surgical treatment in proximal bile duct cancer. A single-center experience. Ann Surg 224(5):628–638PubMedCrossRefGoogle Scholar
  24. 24.
    Nagino M, Nimura Y, Kamiya J et al (1998) Segmental liver resections for hilar cholangiocarcinoma. Hepatogastroenterology 45(19):7–13PubMedGoogle Scholar
  25. 25.
    Ogura Y, Kawarada Y (1998) Surgical strategies for carcinoma of the hepatic duct confluence. Br J Surg 85(1):20–24PubMedCrossRefGoogle Scholar
  26. 26.
    Launois B, Terblanche J, Lakehal M et al (1999) Proximal bile duct cancer: high resectability rate and 5-year survival. Ann Surg 230:266–275PubMedCrossRefGoogle Scholar
  27. 27.
    Todoroki T, Kawamoto T, Koike N et al (2000) Radical resection of hilar bile duct carcinoma and predictors of survival. Br J Surg 87(3):306–313PubMedCrossRefGoogle Scholar
  28. 28.
    Kondo S, Hirano S, Ambo Y et al (2004) Forty consecutive resections of hilar cholangiocarcinoma with no postoperative mortality and no positive ductal margins: results of a prospective study. Ann Surg 240(1):95–101PubMedCrossRefGoogle Scholar
  29. 29.
    Rea DJ, Munoz-Juarez M, Farnell MB et al (2004) Major hepatic resection for hilar cholangiocarcinoma: analysis of 46 patients. Arch Surg 139(5):514–523: discussion 523–525PubMedCrossRefGoogle Scholar
  30. 30.
    Seyama Y, Makuuchi M (2007) Current surgical treatment for bile duct cancer. World J Gastroenterol 13(10):1505–1515PubMedGoogle Scholar
  31. 31.
    Nagino M, Nishio H, Ebata T et al (2007) Intrahepatic cholangiojejunostomy following hepatobiliary resection. Br J Surg 94(1):70–77PubMedCrossRefGoogle Scholar
  32. 32.
    Miyazaki M, Ito H, Nakagawa K et al (1998) Aggressive surgical approaches to hilar cholangiocarcinoma: hepatic or local resection? Surgery 123(2):131–136PubMedGoogle Scholar
  33. 33.
    Madariaga JR, Iwatsuki S, Todo S et al (1998) Liver resection for hilar and peripheral cholangiocarcinomas: a study of 62 cases. Ann Surg 227(1):70–79PubMedCrossRefGoogle Scholar
  34. 34.
    de Castro SM, Kuhlmann KF, Busch OR et al (2005) Incidence and management of biliary leakage after hepaticojejunostomy. J Gastrointest Surg 9(8):1163–1171; discussion 1171–1173PubMedCrossRefGoogle Scholar
  35. 35.
    Miyazaki M, Kato A, Ito H et al (2007) Combined vascular resection in operative resection for hilar cholangiocarcinoma: does it work or not? Surgery 141(5):581–588.PubMedCrossRefGoogle Scholar
  36. 36.
    Ebata T, Nagino M, Kamiya J et al (2003) Hepatectomy with portal vein resection for hilar cholangiocarcinoma: audit of 52 consecutive cases. Ann Surg 238(5):720–727PubMedCrossRefGoogle Scholar
  37. 37.
    Yamanaka N, Yasui C, Yamanaka J et al (2001) Left hemihepatectomy with microsurgical reconstruction of the right-sided hepatic vasculature. A strategy for preserving hepatic function in patients with proximal bile duct cancer. Langenbecks Arch Surg 386(5):364–368PubMedCrossRefGoogle Scholar
  38. 38.
    Sakamoto Y, Sano T, Shimada K et al (2006) Clinical significance of reconstruction of the right hepatic artery for biliary malignancy. Langenbecks Arch Surg 391(3):203–208PubMedCrossRefGoogle Scholar
  39. 39.
    Shimada M, Hamatsu T, Yamashita Y et al (2001) Characteristics of multicentric hepatocellular carcinomas: comparison with intrahepatic metastasis. World J Surg 25(8):991–995PubMedCrossRefGoogle Scholar
  40. 40.
    Miyagawa S, Makuuchi M Kawasaki S et al (1996) Outcome of major hepatectomy with pancreatoduodenectomy for advanced biliary malignancies. World J Surg 20(1):77–80PubMedCrossRefGoogle Scholar
  41. 41.
    Nishio H, Nagino M, Nimura Y (2005) Surgical management of hilar cholangiocarcinoma: the Nagoya experience. HPB 7:259–262Google Scholar
  42. 42.
    Burke EC, Jarnagin WR, Hochwald SN et al (1998) Hilar cholangiocarcinoma: patterns of spread, the importance of hepatic resection for curative operation, and a presurgical clinical staging system. Ann Surg 228:385–394PubMedCrossRefGoogle Scholar
  43. 43.
    Dinant S, Gerhards MF, Busch OR et al (2005) The importance of complete excision of the caudate lobe in resection of hilar cholangiocarcinoma. HPB 7:263–267Google Scholar
  44. 44.
    Cameron JL, Pitt HA, Zinner MJ et al (1990) Management of proximal cholangiocarcinomas by surgical resection and radiotherapy. Am J Surg 159(1):91–97; discussion 97–98PubMedCrossRefGoogle Scholar
  45. 45.
    Nimura Y, Kamiya J, Kondo S et al (2000) Aggressive preoperative management and extended surgery for hilar cholangiocarcinoma: Nagoya experience. J Hepatobiliary Pancreat Surg 7(2):155–162PubMedCrossRefGoogle Scholar
  46. 46.
    Wakai T, Shirai Y, Moroda T et al (2005) Impact of ductal resection margin status on longterm survival in patients undergoing resection for extrahepatic cholangiocarcinoma. Cancer 103:1210–1216PubMedCrossRefGoogle Scholar
  47. 47.
    Nakeeb A, Pitt HA, Sohn TA et al (1996) Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumours. Ann Surg 224(4):463–473; discussion 473–475PubMedCrossRefGoogle Scholar
  48. 48.
    Surgiura Y, Nakamura S, Iida S et al (1994) Extensive resection of the bile ducts combined with liver resection for cancer of the main hepatic duct junction: a cooperative study of the Keio Bile Duct Cancer Study Group. Surgery 115(4):445–451Google Scholar
  49. 49.
    Iwatsuki S, Todo S, Marsh JW et al (1998) Treatment of hilar cholangiocarcinoma (Klatskin tumours) with hepatic resection or transplantation. J Am Coll Surg 187(4):358–364PubMedCrossRefGoogle Scholar
  50. 50.
    Kitagawa Y, Nagino M, Kamiya J et al (2001) Lymph-node metastasis from hilar cholangio-carcinoma: audit of 110 patients who underwent regional and paraaortic node dissection. Ann Surg 233(3):385–392PubMedCrossRefGoogle Scholar
  51. 51.
    Liu CL, Fan ST, Lo CM et al (2006) Improved operative and survival outcomes of surgical treatment for hilar cholangiocarcinoma. Br J Surg 93(12):1488–1494PubMedCrossRefGoogle Scholar
  52. 52.
    Sakamoto E, Nimura Y, Hayakawa N et al (1998) The pattern of infiltration at the proximal border of hilar bile duct carcinoma: a histologic analysis of 62 resected cases. Ann Surg 227(3):405–411PubMedCrossRefGoogle Scholar

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