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Complicanze ipertensive della gravidanza

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Medicina dell’età prenatale

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Estratto

I disordini ipertensivi rappresentano una delle cause più importanti di mortalità e morbilità materno-fetale (insieme con i disordini emorragici, infettivi e tromboembolici) e allo stesso tempo rimangono uno dei più ampi e controversi capitoli della patologia ostetrica, richiedendo, sia a livello diagnostico che clinico, un’adeguata esperienza medica ed un approccio multidisciplinare.

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Bibliografia

  1. No authors listed (2000) Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 183:S1–S22

    Google Scholar 

  2. ACOG Committee on Practice Bulletins-Obstetrics (2001) Diagnosis and management of preeclampsia and eclampsia. Obstet Gynecol 98:159–167

    Google Scholar 

  3. Zhang J, Zeisler J, Hatch MC, Berkowitz G (1997) Epidemiology of pregnancy-induced hypertension. Epidemiologic Rev 19:218–232

    CAS  Google Scholar 

  4. Roberts JM (1994) Pregnancy-related hypertension. In: Creasy RK, Resnick R (eds) Maternal fetal medicine disorders. Saunders, Philadelphia, pp 804–843

    Google Scholar 

  5. Lindberg S, Axelsson O, Jorner O et al (1988) A prospective controlled five-year follow-up study of primiparas with gestational hypertension. Acta Obstet Gynecol Scand 67:605–609

    Article  Google Scholar 

  6. Pietrantoni M, O’Brien WF (1994) The current impact of the hypertensive disorders of pregnancy. Clin Exp Hypertens 16:479–492

    Article  PubMed  CAS  Google Scholar 

  7. Eskenazi B, Fenster L, Sidney S (1991) A multivariate analysis of risk factors for preeclampsia. JAMA 266:237–241

    Article  PubMed  CAS  Google Scholar 

  8. Sibai BM, Gordon T, Thorn E et al and the National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units (1995) Risk factors for preeclampsia in healthy nulliparous women: a prospective multicenter study. Am J Obstet Gynecol 172:642–648

    Google Scholar 

  9. Sibai BM, Lindheimer M, Hauth J et al (1998) Risk factors for preeclampsia, abruptio placentae, and adverse neonatal outcomes among women with chronic hypertension N Engl J Med 339:667–671

    CAS  Google Scholar 

  10. Meyer NL, Mercer BM, Friedman SA, Sibai BM (1994) Urinary dipstick protein —A poor predictor of absent or severe proteinuria. Am J Obstet Gynecol 170:137–141

    PubMed  CAS  Google Scholar 

  11. Pijnenborg R, Dixon G, Robertson WB, Brosens I (1980) Trophoblastic invasion of human deciduas from 8–18 weeks of pregnancy. Placenta 1:3–19

    Article  PubMed  CAS  Google Scholar 

  12. Zhou Y, McMaster M, Woo K et al (2002) Vascular endothelial growth factor legends and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes and low platelets syndrome. Am J Pathol 160:1405–1423

    PubMed  CAS  Google Scholar 

  13. Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (1999) Vascular endothelial growth factor (VEGF) and its receptors FASEB 13:9–22

    CAS  Google Scholar 

  14. Hornig C, Weich HA (1999) Soluble VEGF receptors. Angiogenesis 3:33–39

    Article  PubMed  CAS  Google Scholar 

  15. Miyamoto S, Katz BZ, Lafrenie RM, Yamada KM (1998) Fibronectin and integrins in cell adhesion, signalling, and morphogenesis Ann N Y Acad Sci 857:119–129

    CAS  Google Scholar 

  16. Madazli R, Budak E, Calay Z, Aksu MF (2000) Correlation between placental bed biopsy findings, vascular cell adhesion molecule and fibronectin levels in preeclampsia. Br J Obstet Gynaecol 107:514–518

    CAS  Google Scholar 

  17. Thaler I, Manor D, Itskovitz J et al (1990) Changes in uterine blood flow during human pregnancy. Am J Obstet Gynecol 162:121–125

    PubMed  CAS  Google Scholar 

  18. Dekker GA, Sibai BM (1998) Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 179:1359–1375

    Article  PubMed  CAS  Google Scholar 

  19. Dekker GA, de Vries JL, Doelitzsch PM et al (1995) Underlying disorders associated with severe eary-onset preeclampsia. Am J Obstet Gynecol 173:1042–1048

    Article  PubMed  CAS  Google Scholar 

  20. Chavarrìa ME, Lara-Gonzàlez L, Gonzàlez-Gleason A et al (2002) Maternal plasma cellular fibronectin concentrations in normal and preeclamptic pregnancies: a longitudinal study for early prediction of preeclampsia. Am J Obstet Gynecol 187:595–601

    Article  PubMed  Google Scholar 

  21. Eriksen HO, Kern Hansen P, Brocks V, Jensen BA (1987) Plasma fibronectin concentration in normal pregnancy and preeclampsia. Acta Obstet Gynecol Scand 66:25–28

    Article  PubMed  CAS  Google Scholar 

  22. Friedman SA, de Groot CJM, Taylor RN et al (1994) Plasma cellular fibronectin as a measure of endothelial involvement in preeclampsia and intra uterine growth retardation. Am J Obstet Gynecol 170:838–841

    PubMed  CAS  Google Scholar 

  23. Gredmark T, Bergman B, Hellstrom L (1999) Total fibronectin in maternal plasma as a predictor for preeclampsia. Gynecol Obstet Invest 47:89–94

    Article  PubMed  CAS  Google Scholar 

  24. Tranquilli AL, Bezzeccheri V, Giannubilo SR et al (2004) Amniotic vascular endothelial growth factor (VEGF) and nitric oxide (NO) in women with subsequent preeclampsia. Eur J Obstet Reprod Biol 113:17–20

    Article  CAS  Google Scholar 

  25. Graninger W, Tatra G, Pirich K, Nasr F (1985) Low antithrombin III and high plasma fibronectin in preeclampsia. Eur J Obstet Gynecol Reprod Biol 19:223–229

    Article  PubMed  CAS  Google Scholar 

  26. Lockwood CJ, Peters JH (1990) Increased plasma levels of ED1+ cellular fibronectin precede the clinical signs of preeclampsia. Am J Obstet Gynecol 162:358–362

    PubMed  CAS  Google Scholar 

  27. Redline RW, Patterson P (1995) Preeclampsia is associated with an excess of proliferative immature intermediate trophoblast. Hum Pathol 26:594–600

    Article  PubMed  CAS  Google Scholar 

  28. Shaarawy M, El Didy H (1996) Thrombomodulin, plasminogen activator inhibitor type 1 (PAI-1) and fibronectin as biomarkers of endothelial damage in preeclampsia and eclampsia. Int J Gynecol Obstet 55:135–139

    Article  CAS  Google Scholar 

  29. Sudd SS, Gupta I, Dhaliwal LK et al (1999) Serial plasma fibronectin levels in pre-eclamptic and normotensive women. Int J Gynecol Obstet 66:123–128

    Article  Google Scholar 

  30. Matthiesen L, Berg G, Ernerudh J et al (2005) Immunology of preeclampsia. Chem Immunol Allergy 89:49–61

    PubMed  CAS  Google Scholar 

  31. Redman CWG (1991) Immunology of preeclampsia. Semin Perinatol 15:257–262

    PubMed  CAS  Google Scholar 

  32. Chesley LC, Cooper DW (1986) Genetics of hypertension in pregnancy: possible single gene control of preeclampsia and eclampsia in the descendants of eclamptic women. Br J Obstet Gynaecol 93:898–908

    PubMed  CAS  Google Scholar 

  33. Thadhani R, Mutter WP, Wolf M et al (2004) First trimester placental growth factor and soluble Fms-like tyrosine kinase 1 and risk for preeclampsia. J Clin Endocrinol Metab 89:770–775

    Article  PubMed  CAS  Google Scholar 

  34. Levine RJ, Maynard SE, Qian C et al (2004) Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350:672–683

    Article  PubMed  CAS  Google Scholar 

  35. Buhimschi CS, Norwitz ER, Funai E et al (2005) Urinary angiogenetic factors cluster hypertensive disorders and identify women with severe preeclampsia. Am J Obstet Gynecol 192:734–741

    Article  PubMed  CAS  Google Scholar 

  36. Villar J (2005) Large trial or meta-analysis? That is not the question. Best Pract Res Clin Obstetric Gynecol 19:27–35

    Google Scholar 

  37. Poppas A, Shroff SG, Korcarz CE et al (1997) Serial assessment of the cardiovascular system in normal pregnancy:role of arterial compliance and pulsatile arterial load. Circulation 95:2407–2415

    PubMed  CAS  Google Scholar 

  38. Valensise H, Novelli GP, Vasapollo B et al (2001) Maternal diastolic dysfunction and left ventricular geometry in gestational hypertension. Hypertension 37:1209–1215

    PubMed  CAS  Google Scholar 

  39. Katz R, Karliner JS, Resink R (1978) Effects of a natural overload state (pregnancy) on left ventricular performance in normal human subjects. Circulation 58:434–441

    PubMed  CAS  Google Scholar 

  40. Valensise H, Vasapollo B, Novelli GP et al (2004) Total body water estimation and maternal cardiac systolic function assessment in normal and gestational hypertensive pregnant women. Med Sci Monit 10:CR530–CR534

    PubMed  Google Scholar 

  41. Eremina V, Sood M, Haigh J et al (2003) Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal disease. J Clin Invest 11:707–716

    Article  CAS  Google Scholar 

  42. Ferrazani S, DeCarolis S, Pomini F et al (1994) The duration of hypertension in the puerperium of preeclamptic women —Relationship with renal impairment and week of delivery. Am J Obstet Gynecol 17:506–512

    Google Scholar 

  43. Chien PWF, Arnott N, Gordon A et al (2000) How useful is uterine artery Doppler flow velocimetry in the prediction of preeclampsia, intrauterine growth retardation and perinatal death? An overview. BJOG 107:196–208

    Article  CAS  Google Scholar 

  44. Valensise H, Novelli GP, Vasapollo B et al (2000) Maternal cardiac systolic and diastolic function; relationship with uteroplacental resistences: a Doppler and echocardiographic longitudinal Study. Ultrasound Obstet gynecol 15:487–497

    Article  PubMed  CAS  Google Scholar 

  45. Thadhani, Johnson RJ, Karumanchi SA (2005) Hypertension during pregnancy: a disorder begging for pathophysiological support. Hypertension 46:1250–1251

    Article  PubMed  CAS  Google Scholar 

  46. Taylor SR, Freeman L, North RA (2001) Evaluation of ambulatory and self-initiated blood pressure monitors by pregnant and postpartum women. Hypertension Pregnancy 20:25–33

    Article  CAS  Google Scholar 

  47. Paternoster DM, Stella A, Mussap M et al (1999) Predictive markers of preeclampsia in hypertensive disorders of pregnancy. Int J Gynecol Obstet 66:237–243

    Article  CAS  Google Scholar 

  48. Benigni A, Gregorini G, Frusca T et al (1989) Effect of lowdose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension. N Engl J Med 321:357–362

    Article  PubMed  CAS  Google Scholar 

  49. Caritis S, Sibai B, Hauth J et al (1998) Low-dose aspirin to prevent preeclampsia in women at high risk. N Engl J Med 338:701–705

    Article  PubMed  CAS  Google Scholar 

  50. CLASP, Collaborative Low-dose Aspirin Study in Pregnancy Collaborative Group (1994) A randomized trial of low-dose aspirin for prevention and tretment of preeclampsia among 9364 pregnant women. Lancet 343:619

    Article  Google Scholar 

  51. Coomarasamy A, Papaioannou S, Gee H, Khan KS (2001) Aspirin for the prevention of preeclampsia in women with abnormal uterine artery Doppler —A meta-analysis. Obstet Gynecol 98:861–866

    Article  PubMed  CAS  Google Scholar 

  52. Italian Study of Aspirin in pregnancy (1993) Low-dose aspirin in prevention and treatment of intrauterine growth retardation and pregnancy-induced hypertension. Lancet 8842:396–399

    Google Scholar 

  53. Wallenburg HC, Dekker GA, Makovitz JW, Rotmans P (1986) Low-dose aspirin prevents pregnancy-induced hypertension and pre-eclampsia in angiotensin-sensitive primigravidae. Lancet 1:1–3

    Article  PubMed  CAS  Google Scholar 

  54. Olsen SF, Secher NJ, Tabor A et al (2000) Randomised clinical trials of fish oil supplementation in high risk pregnancies. Br J Ob Gyn 107:382–395

    CAS  Google Scholar 

  55. Chappell LC, Seed PT, Briley AL et al (1999) Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk —A randomized trial. Lancet 354:810–816

    PubMed  CAS  Google Scholar 

  56. Atallah AN, Hofmeyr GJ, Duley L (2000) Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev (3):CD001059

    Google Scholar 

  57. Levine RJ, Hauth JC, Curet LB et al (1997) Trial of calcium to prevent preeclampsia. N Engl J Med 337:69–76

    Article  PubMed  CAS  Google Scholar 

  58. Buchbinder A, Sibai BM, Caritis S et al (2002) Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia. Am J Obstet Gynecol 186:66–71

    Article  PubMed  Google Scholar 

  59. Fink JC, Schwartz SM, Benedetti TI, Stehman-Breen CO (1998) Increased risk of adverse maternal and infant outcomes among women with renal disease. Paediatr Perinat Epidemiol 12:277–287

    Article  PubMed  CAS  Google Scholar 

  60. Hauth JC, Ewell MG, Levine RL et al (2000) Pregnancy outcomes in healthy nulliparas women who subsequently developed hypertension. Obstet Gynecol 95:24–28

    Article  PubMed  CAS  Google Scholar 

  61. Hnat MD, Sibai BM, Caritis S et al (2002) Perinatal outcome in women with recurrent preeclampsia compared with women who develop preeclampsia as nulliparas. Am J Obstet Gynecol 186:422–426

    Article  PubMed  Google Scholar 

  62. Sibai BM, Sarinoglu C, Mercer BM (1992) Eclampsia VII. Pregnancy outcome after eclampsia and long term prognosis. Am J Obstet Gynecol 166:1757–1763

    PubMed  CAS  Google Scholar 

  63. Barton JR, Hiett AK, Conover WB (1990) The use of nifedipine during the postpartum period in patients with severe preeclampsia. Am J Obstet Gynecol 162:788–792

    PubMed  CAS  Google Scholar 

  64. Valensise H, Larciprete G, Vasapollo B et al (2003) Nifedipine-induced changes in body composition in hypertensive patients at term. Eur J Obstet Gynecol Reprod Biol 106:139–143

    Article  PubMed  CAS  Google Scholar 

  65. Brown MA, Hague WM, Higgins J et al (2000) The detection, investigation and management of hypertension in pregnancy. Aust N Z J Obstet Gynaecol 2:133–155

    Article  Google Scholar 

  66. Magee LA, Ornstein MP, Von Dadelszen P (1999) Fortnightly review —Management of hypertension in pregnancy. BMJ 318:1332–1336

    PubMed  CAS  Google Scholar 

  67. Sibai BM (2003) Diagnosis and management of gestional hypertension and preeclampsia. Obstet Gynecol 102:181–192

    Article  PubMed  Google Scholar 

  68. Schiff E, Friedman SA, Sibai BM (1994) Conservative management of severe preeclampsia remote from term. Obstet Gynecol 84:620–630

    Google Scholar 

  69. Barton JR, Witlin AG, Sibai BM (1999) Management of mild preeclampsia. Clin Obstet Gynecol 42:465–469

    Article  Google Scholar 

  70. Head BB, Owen J, Vincent RD et al (2002) Arandomized trial of intrapartum analgesia in women with severe preeclampsia. Obstet Gynecol 99:452–457

    Article  PubMed  Google Scholar 

  71. The Maggie Trial Collaborative Group (2002) Do women with preeclampsia and their babies, benefit from magnesium sulphate? The Maggie Trial. A randomized placebo controlled trial. Lancet 359:1877–1890

    Article  Google Scholar 

  72. Cunningham FG, Twickler DM (2000) Cerebral edema complicating eclampsia. Am J Obstet Gynecol 182:94–100

    Article  PubMed  CAS  Google Scholar 

  73. Dahmus MA, Barton JR, Sibai BM (1992) Cerebral imaging in eclampsia: magnetic resonance imaging versus computed tomography. Am J Obstet Gynecol 167:935–941

    PubMed  CAS  Google Scholar 

  74. Lopez-Llera M (1993) Recurrent eclampsia; clinical data, morbidity and pathogenic considerations. Eur J Obstet Gynecol Reprod Biol 50:39–45

    Article  PubMed  CAS  Google Scholar 

  75. Schwartz RB, Feske SK, Polak JF et al (2000) Preeclampsiaeclampsia: clinical and neuroradiographic correlates and insights into the pathogenesis of hypertensive encephalopathy. Radiology 217:371–376

    PubMed  CAS  Google Scholar 

  76. Sibai BM (1990) Eclampsia. VI. Maternal-perinatal outcome in 254 consecutive cases. Am J Obstet Gynecol 163:1049–1055

    PubMed  CAS  Google Scholar 

  77. Campbell DM, Templeton AA (1980) Is eclampsia preventable? In: Bonnar J, MacGillivray I, Symonds EM (eds) Pregnancy hypertension, proceedings. University Park Press, Baltimora, pp 483–488

    Google Scholar 

  78. Sibai BM (2004) Magnesium sulfate prophylaxis in preeclampsia: lessons learned from recent trials. Am J Obstet Gynecol 190:1520–1526

    Article  PubMed  CAS  Google Scholar 

  79. Richards AM, Moodley J, Graham DI, Bullock MR (1986) Active management of the unconscious eclamptic patient. Br J Obstet Gynaecol 93:554–621

    PubMed  CAS  Google Scholar 

  80. Sibai BM, Makie WC, Harvey CJ, Gonzalez AR (1987) Pulmonary edema in severe preeclampsia-eclampsia: analysis of 37 consecutive cases. Am J Obstet Gynecol 156:1174–1179

    PubMed  CAS  Google Scholar 

  81. Ben Ami M, Giladi Y, Shalev E (1994) The combination of magnesium sulfate and nifedipine: a cause of neuromuscular blockade. Br J Obstet Gynaecol 101:262–263

    PubMed  CAS  Google Scholar 

  82. Snyder SW, Cardwell MS (1989) Neuromuscular blockade with magnesium sulfate and nifedipine. Am J Obstet Gynecol 161:35–36

    PubMed  CAS  Google Scholar 

  83. No authors listed (1995) Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial. Lancet 345:1455–1463

    Google Scholar 

  84. Witlin AG, Sibai BM (1998) Magnesium sulfate in preeclampsia and eclampsia. Obstet Gynecol 92:883–889

    Article  PubMed  CAS  Google Scholar 

  85. Witlin AG, Friedman SA, Egerman RS et al (1997) Cerebrovascular disorders complicating pregnancy: beyond eclampsia. Am J Obstet Gynecol 176:1139–1148

    Article  PubMed  CAS  Google Scholar 

  86. Zeeman GG, Fleckenstein JL, Twickler DM, Cunningham FG (2004) Cerebral infarction in eclampsia. Am J Obstet Gynecol 190:714–720

    Article  PubMed  Google Scholar 

  87. Belfort MA, Grunewald C, Saade GR et al (1999) Preeclampsia may cause both overperfusion and underperfusion of the brain. Acta Obstet Gynecol Scand 78:586–591

    Article  PubMed  CAS  Google Scholar 

  88. Chames MC, Livingston JC, Invester TS et al (2002) Late postpartum eclampsia: a preventable disease? Am J Obstet Gynecol 186:1174–1177

    Article  PubMed  Google Scholar 

  89. Lubarsky SL, Barton JR, Friedman SA et al (1994) Late postpartum eclampsia revisited. Obstet Gynecol 83:502–505

    Article  PubMed  CAS  Google Scholar 

  90. Adelusi B, Ojengbede OA (1986) Reproductive performance after eclampsia. Int J Gynaecol Obstet 24:183–189

    Article  PubMed  CAS  Google Scholar 

  91. Lopez-Llera M, Horton JLH (1974) Pregnancy after eclampsia. Am J Obstet Gynecol 119:193–198

    PubMed  CAS  Google Scholar 

  92. Bryans CI, Southerland WL, Zuspan FP (1963) Eclampsia: a follow-up study of eclamptic women. Obstet Gynecol 21:701–707

    PubMed  Google Scholar 

  93. The Magpie Trial Collaborative Group (2002) Do women with preeclampsia, and their babies, benefit from magnesium sulfate? The Magpie Trial: a randomized placebocontrolled trial. Lancet 359:1877–1890

    Article  Google Scholar 

  94. Weinstein L (1985) Preeclampsia-eclampsia with hemolysis, elevated liver enzymes and thrombocytopenia. Obstet Gynecol 66:657–660

    PubMed  CAS  Google Scholar 

  95. Haddad B, Barton JR, Livingston JC et al (2000) Risk factors for adverse maternal outcomes among women with HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome. Am J Obstet Gynecol 183:444–448

    Article  PubMed  CAS  Google Scholar 

  96. Martin JN Jr, Rinehart B, May WL et al (1999) The spectrum of severe preeclampsia: comparative analysis by HELLP syndrome classification. Am J Obstet Gynecol 180:1373–1384

    Article  PubMed  Google Scholar 

  97. Sibai BM (1990) The HELLP Syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing? Am J Obstet Gynecol 162:311–316

    PubMed  CAS  Google Scholar 

  98. Audibert F, Friedmm SA, Frangieb AY, Sibai BM (1996) Clinical utility of strict diagnostic criteria for the HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. Am J Obstet Gynecol 175:460–464

    Article  PubMed  CAS  Google Scholar 

  99. Rath W, Loos W, Kuhn W, Graeff H (1990) The importance of early laboratory screening methods for maternal and fetal outcome in cases of HELLP syndrome. Eur J Obstet Gynccol Rep rod Biol 36:43–51

    Article  CAS  Google Scholar 

  100. Clark SL, Phelm JR, Allen SH, Golde SR (1987) Antepartum reversal of hematologic abnormalities associated with the HELLP syndrome. J Reprod Med 32:781–784

    Google Scholar 

  101. Pritchard JA, Weisman R, Ratoff OD, Vosburg GJ (1954) Intravascular hemolysis, thrombocytopenia, and other hematologic abnormalities associated with severe toxemia of pregnancy. N Engl J Med 250:89–98

    Article  PubMed  CAS  Google Scholar 

  102. Sibai BM, Ramadm MK, Usta I et al (1993) Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome). Am J Obstet Gynecol 169:1000–1006

    PubMed  CAS  Google Scholar 

  103. Woods JB, Blake PG, Perry KG Jr et al (1992) Ascites: a portent of cardiopulmonary complications in the preeclamptic patient with the syndrome of hemolysis elevated liver enzymes, and low platelets. Obstet Gynecol 80:87–91

    PubMed  CAS  Google Scholar 

  104. Abramovici D, Friedman SA, Mercer BM et al (1999) Neonatal outcome in severe preeclampsia at 24 to 36 weeks’ gestation: does HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome matter? Am J Obstet Gynecol 180:221–225

    Article  PubMed  CAS  Google Scholar 

  105. Van Pampus MG, Wolf H, Westenberg SM et al (1998) Maternal and perinatal outcome after expectant management of the HELLP syndrome compared with preeclampsia without HELLP syndrome. Eur J Obstet Gynecol Reprod Biol 76:31–36

    Article  PubMed  Google Scholar 

  106. Van Pampus MG, Wolf H, Ilsen A, Treffers PE (2000) Maternal outcome following temporizing management of the (H)ELLP syndrome. Hypertens Pregnancy 19:211–220

    Article  PubMed  Google Scholar 

  107. Sibai BM, Ramadan MK (1993) Acute renal failure in pregnancies complicated by hemolysis, elevated liver enzymes, and low platelets. Am J Obstet Gynecol 168:1682–1690

    PubMed  CAS  Google Scholar 

  108. Drakeley AJ, LeRoux PA, Anthony J, Penny J (2002) Acute renal failure complicating severe preeclampsia requiring admission to obstetric intensive care unit. Am J Obstet Gynecol 186:253–256

    Article  PubMed  Google Scholar 

  109. Visser XV, Wallenburg HCS (1995) Temporising management of severe preeclampsia with and without the HELLP syndrome. Br J Obstet Gynaecol 102:111–117

    PubMed  CAS  Google Scholar 

  110. Martin JN Jr, Perry KG, Blake PG et al (1997) Better maternal outcomes are achieved with dexamethasone therapy for postpartum HELLP (hemolysis, elevated liver enzymes, and thrombocytopenia) syndrome. Am J Obstet Gynecol 177:1011–1017

    Article  PubMed  Google Scholar 

  111. Vigil-DeGracia P, Garcia-Caceres E (1997) Dexamethasone in the postpartum treatment of HELLP syndrome. Am J Gynaecol Obstet 59:217–221

    CAS  Google Scholar 

  112. Isler CM, Barrilleaux PS, Magann EF et al (2001) A prospective, randomized trial comparing the efficacy of dexamethasone and betamethasone for the treatment of antepartum HELLP syndrome. Am J Obstet Gynecol 184:1332–1339

    Article  PubMed  CAS  Google Scholar 

  113. Crane JMG, Tabarsi B, Hutehens D (2003) The maternal benefits of corticosteroids with HELLP syndrome. J Obstet Gynaecol Can 25:650–655

    PubMed  Google Scholar 

  114. Magann EF, Bass D, Chauhm SP et al (1994) Antepartum corticosteroids: disease stabilization in patients with the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP). Am J Obstet Gynecol 171:1148–1153

    PubMed  CAS  Google Scholar 

  115. Magann EF, Perry KG Jr, Meydrech EF et al (1994) Postpartum corticosteroids: accelerated recovery from the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP). Am J Obstet Gynecol 171:1154–1158

    PubMed  CAS  Google Scholar 

  116. Martin JN Jr, Thigsen BD, Rose CH et al (2003) Maternal benefit of high-dose intravenous corticosteroid therapy for HELLP. Am J Obstet Gynecol 189:830–834

    Article  PubMed  CAS  Google Scholar 

  117. O’Brien JM, Milligm DA, Barton JR (2000) Impact of high-dose corticosteroid therapy for patients with HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome. Am J Obstet Gynecol 183:921–924

    Article  PubMed  CAS  Google Scholar 

  118. Tompkins MJ, Thiagarajah S (1999) HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome: the benefit of corticosteroids. Am J Obstet Gynecol 181:304–309

    Article  PubMed  CAS  Google Scholar 

  119. Amorium MMR, Santos LC, Faundes A (1999) Corticosteroid therapy for prevention of respiratory distress syndrome in severe preeclampsia. Am J Obstet Gynecol 180:1283–1288

    Article  Google Scholar 

  120. No authors listed (1995) Effect of corticosteroids for fetal maturation on perinatal outcomes: NIB Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes. JAMA 273:413–418

    Google Scholar 

  121. Heller CS, Elliott JP (1997) High-order multiple pregnancies complicated by HELLP syndrome: a report of four cases with corticosteroid therapy to prolong gestation. J Reprod Med 42:743–746

    PubMed  CAS  Google Scholar 

  122. O’Brien JM, Shumate SA, Satchwell SL et al (2002) Maternal benefit to corticosteroid therapy in patients with HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome: impact on the rate of regional anesthesia. Am J Obstet Gynecol 186:475–479

    Article  PubMed  CAS  Google Scholar 

  123. Mac Kenna J, Dover NL, Brame RG (1983) Preeclampsia associated with hemolysis, elevated liver enzymes, and low platelets: an obstetric emergency? Obstet Gynecol 62:751–754

    Google Scholar 

  124. Martin JN Jr, Files JC, Blake PG et al (1995) Postpartum plasma exchange for atypical preeclampsia-eclampsia as HELLP syndrome. Am J Obstet Gynecol 172:1107–1127

    Article  PubMed  Google Scholar 

  125. Burt VL, Whetton P, Rochella EJ et al (1995) Prevalence of hypertension in the US adult population — Results from the third national health and nutrition examination survey, 1988–1991. Hypertension 23:305–313

    Google Scholar 

  126. McCowan LM, Buist RG, North RA, Gamble G (1996) Perinatal morbidity in chronic hypertension. Br J Obstet Gynaecol 103:123–129

    PubMed  CAS  Google Scholar 

  127. Sibai BM, Anderson GD (1986) Pregnancy outcome of intensive therapy in severe hypertension in first trimester. Obstet Gynecol 67:517–522

    PubMed  CAS  Google Scholar 

  128. Sibai BM, Villar MA, Mabie BC (1990) Acute renal failure in hypertensive disorders of pregnancy —Pregnancy outcome and remote prognosis in thirty-one consecutive cases. Am J Obstet Gynecol 162:777–783

    PubMed  CAS  Google Scholar 

  129. Brown MA, Hague WM, Higgins J et al (2000) The detection, investigation and management of hypertension in pregnancy. Full consensus statement. Aust N Z J Obstet Gynaecol 40:139–155

    Article  PubMed  CAS  Google Scholar 

  130. Ferrer RL, Sibai BM, Murlow CD et al (2000) Management of mild chronic hypertension during pregnancy —A review. Obstet Gynecol 96:849–860

    Article  PubMed  CAS  Google Scholar 

  131. Bartolus R, Ricci E, Chatenoud L, Parazzini F (2000) Nifedipine administration in pregnancy: effect on the development of children at 18 months. Br J Obstet Gynaecol 107:792–794

    Google Scholar 

  132. Mabie WC, Ratts TE, Ramanathan KB, Sibai BM et al (1988) Circulatory congestion in obese hypertensive women —A subset of pulmonary edema in pregnancy. Obstet Gynecol 72:553–558

    PubMed  CAS  Google Scholar 

  133. Butters L, Kennedy S, Rubin PC (1990) Atenolol in essential hypertension during pregnancy. BMJ 301:587–589

    PubMed  CAS  Google Scholar 

  134. Rey E, Lelorier J, Burgess E et al (1997) Report of the Canadian Hypertension Society Consensus Conference —3. Pharmacologic treatment of hypertensive disorders in pregnancy. CMAJ 157:1245–1254

    PubMed  CAS  Google Scholar 

  135. Umans JG, Lindheimer MD et al (1998) Antihypertensive treatment. In: Lindheimer MD, Roberts JM, Cunningham FG (eds) Chesley’s hypertensive disorders in pregnancy, 2nd ed. Appleton and Lange, Norwalk, pp 581–604

    Google Scholar 

  136. Easterling TR, Carr DB, Brateng D et al (2001) Treatment of hypertension in pregnancy — Effect of atenolol on maternal disease, preterm delivery and fetal growth. Obstet Gynecol 98:427–433

    Article  PubMed  CAS  Google Scholar 

  137. Easterling TR, Brateng D, Schmucker B et al (1999) Prevention of preeclampsia —A randomized trial of atenolol in hyperdynamic patients before onset of hypertension. Obstet Gynecol 93:725–733

    Article  PubMed  CAS  Google Scholar 

  138. Sibai BM, Mabie WC, Shamsa F et al (1990) A comparison of no medication versus methyldopa or labetalol in chronic hypertension during pregnancy. Am J Obstet Gynecol 162:960–966

    PubMed  CAS  Google Scholar 

  139. Sibai BM, Grossman RA, Grossman HG (1984) Effects of diuretics on plasma volume in pregnancies with longterm hypertension. Am J Obstet Gynecol 150:831–835

    PubMed  CAS  Google Scholar 

  140. Collins R, Yusuf S, Peto R (1985) Overview of randomized trials of diuretics in pregnancy. Br Med J 290:17–23

    Article  CAS  Google Scholar 

  141. Gruppo di Studio Ipertensione in Gravidanza (1998) Nifedipine versus expectant management in mild to moderate hypertension in pregnancy. Br J Obstet Gynaecol 105:718–722

    Google Scholar 

  142. Magee LA, Schick B, Donnenfeld AE et al (1996) The safety of calcium channel blockers in human pregnancy —A prospective, multicenter cohort study. Am J Obstet Gynecol 174:823–828

    Article  PubMed  CAS  Google Scholar 

  143. Cockburn J, Moar VA, Ounsted M, Redman LW (1982) Final report of study on hypertension during pregnancy —The effect of specific treatment on the growth and development of the children. Lancet 1:647–649

    Article  PubMed  CAS  Google Scholar 

  144. Magee LA, Duley L (2001) Oral beta-blockers for mild to moderate hypertension during pregnancy. Cochrane Database Syst Rev 4:CD002863

    Google Scholar 

  145. Jones DC, Hayslett JP (1996) Outcome of pregnancy in women with moderate or severe renal insufficiency. N Engl J Med 335:226–232

    Article  PubMed  CAS  Google Scholar 

  146. Sibai BM, Abdella TN, Anderson GD (1983) Pregnancy outcome in 211 patients with mild chronic hypertension. Obstet Gynecol 61:571–576

    PubMed  CAS  Google Scholar 

  147. Briggs GG, Freeman RK, Yaffee SJ (1998) Drugs in pregnancy and lactation —A reference guide to fetal and neonatal risk, 5th ed. Williams & Wilkins, Baltimore

    Google Scholar 

  148. White WB (1984) Management of hypertension during lactation. Hypertension 6:297–300

    PubMed  CAS  Google Scholar 

  149. American College of Obstetricians and Gynecologists (2001) Chronic hypertension in pregnancy. ACOG practice bulletin no. 29, American College of Obstetricians and Gynecologists, Washington

    Google Scholar 

  150. Rey E, Couturier A (1994) The prognosis of pregnancy in women with chronic hypertension. Am J Obstet Gynecol 171:410–416

    PubMed  CAS  Google Scholar 

  151. Wolf M, Shah A, Lam C et al (2005) Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies. Am J Obstet Gynecol 193:16–72

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Dipartimento di Chirurgia Area Ostetrico Ginecologica, Università degli Studi di Roma “Tor Vergata”, Roma

    Letizia Brienza, Maria Elena Pietrolucci & Domenico Arduini

  2. Dipartimento di Chirurgia Sezione di Ginecologia e Ostetricia, Università degli Studi di Roma “Tor Vergata”, Roma

    Herbert Valensise

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  1. Letizia Brienza
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  2. Maria Elena Pietrolucci
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  3. Herbert Valensise
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  4. Domenico Arduini
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Brienza, L., Pietrolucci, M.E., Valensise, H., Arduini, D. (2008). Complicanze ipertensive della gravidanza. In: Medicina dell’età prenatale. Springer, Milano. https://doi.org/10.1007/978-88-470-0688-1_17

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