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Selective Digestive Tract Decontamination in Intensive Care Medicine: a Practical Guide to Controlling Infection pp 73–87Cite as

Compounding Medication for Digestive Decontamination: Pharmaceutical Aspects

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Abstract

To assess the effect of selective decontamination of the digestive tract on respiratory tract infections and survival of patients treated in an intensive care unit, meta-analyses of clinical studies comparing patients treated with selective decontamination and untreated controls have been carried out. Analyses of these studies have shown a protective effect of selective decontamination on infections. On the other hand, the mortality benefit has been shown only recently [1]. Earlier studies with historical controls and randomised trials showed that mortality was not significantly different between treatment and control patients. The evidence from these studies is consistent with an effect of selective decontamination of the digestive tract on survival of patients in the intensive care unit, in addition to a clear preventive effect on the occurrence of respiratory tract infections [2]–[12].

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Author information

Authors and Affiliations

  1. Pharma Assist, Hoogeveen, The Netherlands

    Rients Schootstra PharmD (Hospital pharmacist)

  2. Department of Hospital Pharmacy, Medical Centre Leeuwarden, Leeuwarden, The Netherlands

    Jan P. Yska PharmD (Hospital Pharmacist)

Authors
  1. Rients Schootstra PharmD
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  2. Jan P. Yska PharmD
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands

    Peter H. J. van der Voort (Internist-intensivist) (Internist-intensivist)

  2. Department of Clinical Microbiology and Infection Control, Royal Liverpool Children’s NHS Trust of Alder Hey, Liverpool, UK

    Hendrick K. F. van Saene

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© 2008 Springer

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Schootstra, R., Yska, J.P. (2008). Compounding Medication for Digestive Decontamination: Pharmaceutical Aspects. In: van der Voort, P.H.J., van Saene, H.K.F. (eds) Selective Digestive Tract Decontamination in Intensive Care Medicine: a Practical Guide to Controlling Infection. Springer, Milano. https://doi.org/10.1007/978-88-470-0653-9_5

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  • DOI: https://doi.org/10.1007/978-88-470-0653-9_5

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0652-2

  • Online ISBN: 978-88-470-0653-9

  • eBook Packages: MedicineMedicine (R0)

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