Endocrine Aspects of Neural Tube Defects

  • Abdullah Bereket


Children with open neural tube defects (NTDs) are prone to several endocrine problems. Short stature and precocious puberty are the most common endocrine sequelae of NTDs; however, abnormalities in thyroid hormone and prolactin (PRL) have also been reported. Thus, multidisciplinary evaluation and management of NTDs should also include a thorough endocrine evaluation.


Spina Bifida Standard Deviation Score Neural Tube Defect Precocious Puberty Growth Hormone Treatment 


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  1. 1.
    Charney EB, Rosenblum M, Finegold D (1981) Linear growth in a population of children with myelomeningocele. Z Kinderchir 34:415–491PubMedGoogle Scholar
  2. 2.
    Klauschie J, Rose SR (1996) Incidence of short stature in children with hydrocephalus. J Pediatr Endocrinol Metab 9:181–187PubMedGoogle Scholar
  3. 3.
    Rotenstein D, Adams M, Reigel DH (1995) Adult stature and anthropomorphic measurements of patients with myelomeningocele. Eur J Pediatr 154:398–402PubMedCrossRefGoogle Scholar
  4. 4.
    Hoyt WF, Kaplan SL, Grumbach MM (1970) Septooptic dysplasia and pituitary dwarfism. Lancet 1:893–894PubMedCrossRefGoogle Scholar
  5. 5.
    Rudman D, Duns T, Priest JH et al (1978) Prevalence of growth hormone deficiency in children with cleft lip or palate. J Pediatr 93:378–382PubMedCrossRefGoogle Scholar
  6. 6.
    Wacharasindhu S, Asawutmangkul U, Srivuthana S (2005) Endocrine abnormalities in patients with fron — to ethmoidal encephalomeningocele. A pre limi nary study. Horm Res 64:64–67PubMedCrossRefGoogle Scholar
  7. 7.
    Rotenstein D, Flom LL, Reigel DH (1989) Growth hormone treatment accelerates growth of short children with neural tube defects. J Pediatr 115:417–420PubMedCrossRefGoogle Scholar
  8. 8.
    Rotenstein D (1990) Endocrine aspects of open neural tube defects. Neuroscience Journal 12:21–23Google Scholar
  9. 9.
    Lopponen T, Saukkonen AL, Serlo W et al (1997) Reduced levels of growth hormone, insulin-like growth factor-I and binding protein-3 in patients with shunted hydrocephalus. Arch Dis Child 77:32–37PubMedGoogle Scholar
  10. 10.
    Trollmann R, Strehl E, Wenzel D, Dorr HG (1998) Arm span, serum IGF-1 and IGFBP-3 levels as screening parameters for the diagnosis of growth hormone deficiency in patients with myelomeningocele-preliminary data. Eur J Pediatr 157:451–455PubMedCrossRefGoogle Scholar
  11. 11.
    Satin-Smith MS, Katz LL, Thornton P et al (1996) Arm span as measurement of response to growth hormone (GH) treatment in a group of children with meningo — myelocele and GH deficiency. J Clin Endocrinol Metab 81:1654–1656PubMedCrossRefGoogle Scholar
  12. 12.
    Hochhaus F, Butenandt O, Schwarz HP, Ring-Mrozik E (1997) Auxological and endocrinological evaluation of children with hydrocephalus and/or meningomyelocele. Eur J Pediatr 156:597–601PubMedCrossRefGoogle Scholar
  13. 13.
    Lopponen T, Saukkonen AL, Serlo W et al (1995) Slow prepubertal linear growth but early pubertal growth spurt in patients with shunted hydrocephalus. Pediatrics 95:917–923PubMedGoogle Scholar
  14. 14.
    Perrone L, Del Gaizo D, D’Angelo E et al (1994) Endocrine studies in children with myelo me ningo cele. J Pediatr Endocrinol 7:219–23PubMedGoogle Scholar
  15. 15.
    Hochhaus F, Butenandt O, Ring-Mrozik E (1999) One-year treatment with recombinant human growth hormone of children with meningomyelocele and growth hormone deficiency: a comparison of supine length and arm span. J Pediatr Endocrinol Metab 12:153–159PubMedGoogle Scholar
  16. 16.
    Trollmann R, Bakker B, Lundberg M, Doerr HG (2006) Growth in pre-pubertal children with myelo — me ningocele (MMC) on growth hormone (GH): the KIGS experience. Pediatr Rehabil 9:144–148PubMedCrossRefGoogle Scholar
  17. 17.
    Rotenstein D, Bass AN (2004) Treatment to near adult stature of patients with myelomeningocele with recombinant human growth hormone. J Pediatr Endocrinol Metab. 17:1195–1200PubMedGoogle Scholar
  18. 18.
    Rotenstein D, Reigel DH, Lucke JF (1996) Growth of growth hormone-treated and nontreated children before and after tethered spinal cord release. Pediatr Neurosurg 24:237–241PubMedCrossRefGoogle Scholar
  19. 19.
    Furman L, Mortimer JC (1994) Menarche and menstrual function in patients with myelo meningo cele. Dev Medicine and Child Neurol 36:910–917CrossRefGoogle Scholar
  20. 20.
    De Luca F, Muritano M, Rizzo G et al (1985) True precocious puberty: a long term complication in children with shunted non-tumoral hydrocephalus. Helvetica Paediatrica Acta 40:467–472PubMedGoogle Scholar
  21. 21.
    Meyer S, Landau H (1984) Precocious puberty in myelomeningocele patients. J Pediatr Orthop 4:28–31PubMedGoogle Scholar
  22. 22.
    Proos LA, Dahl M, Ahlsten G et al (1996) Increased perinatal intracranial pressure and prediction of early puberty in girls with myelomeningocele. Arch Dis Child 75:42–45PubMedGoogle Scholar
  23. 23.
    Kaplan S, Grumbach M (1990) Pathophysiology and treatment of sexual precocity. J Clin Endocrinol Metab 71:785–789PubMedCrossRefGoogle Scholar
  24. 24.
    Trollmann R, Strehl E, Darr HG (1998) Precocious puberty in children with myelomeningocele: treatment with gonadotropin-releasing hormone analogues. Dev Med Child Neurol 40:38–43PubMedGoogle Scholar
  25. 25.
    Jackson AB, Sipski ML (2005) Reproductive issues for women with spina bifida. J Spinal Cord Med 28:81–91PubMedGoogle Scholar
  26. 26.
    Roberts D, Shepherd RW, Shepherd K (1991) Anthropometry and obesity in myelomeningocele. J Paediatr Child Health 27:83–90PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2008

Authors and Affiliations

  • Abdullah Bereket
    • 1
  1. 1.Division of Pediatric Endocrinology Department of PediatricsMarmara University Medical CenterIstanbulTurkey

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