Managing Hypertrophic Cardiomyopathy: Screening in Young Subjects

  • Maurizio Santomauro
  • Gianluca Botto
  • Corrado Diaco
  • Michele M. Gulizia
  • Giuseppe Marceca
  • Francesco Melandri
  • Franco Naccarella
  • Carla Riganti
  • Massimo Santini
Conference paper


Myocardial diseases (MDs) include an infrequently occurring heterogeneous group of potentially lethal abnormalities in children and young adults. Recent epidemiological studies have shown that dilated and hypertrophic cardiomyopathies are the most frequent morphological substrata of cardiomyopathy in children [1, 2]. Furthermore, MDs have been associated with unexpected sudden death (SD) in apparently healthy people < 35 years old [3]–[9]. Acute myocarditis and hypertrophic cardiomyopathy are the leading causes of SD in this age group. In addition, arrhythmogenic right ventricular cardiomyopathy/dysplasia has been recognized as a relatively frequent cause of SD in southern European countries [4, 9, 10]. In some cases, SD is the first manifestation of disease, although sometimes the child or young adult has had some symptom during their lifetime [11, 12]. The actual incidence and distribution of cardiac SD by sex and age group in well-defined populations are poorly characterized, and only a few observational studies have assessed this problem in children and young adults. Most studies have been done in selected samples or in reference centers, with the consequent bias making it impossible to provide epidemiological data. A population-based observational retrospective study was carried out in children and young adults < 35 years old in the Italian province of Campania between 1998 and 2005 with the aims of assessing the epidemiological and clinical data on MD mortality and determining the causes of SD and non-sudden death (NSD).


Sudden Death Sport Activity Hypertrophic Cardiomyopathy Acute Myocarditis Unexpected Sudden Death 
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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Maurizio Santomauro
    • 1
  • Gianluca Botto
    • 2
  • Corrado Diaco
    • 2
  • Michele M. Gulizia
    • 3
  • Giuseppe Marceca
    • 4
  • Francesco Melandri
    • 5
  • Franco Naccarella
    • 6
  • Carla Riganti
    • 7
  • Massimo Santini
    • 8
  1. 1.Department of Cardiovascular and Internal Medicine, Faculty of Medicine and SurgeryFederico II UniversityNaples
  2. 2.Department of CardiologyS. Anna HospitalComo
  3. 3.Division of CardiologyGaribaldi-Nesima HospitalCatania
  4. 4.Scuola di Specializzazione Medicina del LavoroLa Sapienza UniversityRome
  5. 5.Cardiology UnitNuovo Ospedale CivileSassuolo (MO)
  6. 6.Cardiovascular Epidemiology UnitCardiology Department AUSLBologna
  7. 7.Direzione SanitariaAOU Federico IINaples
  8. 8.Cardiovascular DepartmentSan Filippo Neri HospitalRomeItaly

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