Focus on Optimization of Cardiac Resynchronization Therapy Techniques

  • Maurizio Lunati
  • Yann Poezevara
  • Andrea Boncompagni
Conference paper


Although cardiac resynchronization therapy (CRT) is now a first-line therapy in moderate to severe congestive heart failure patients with broad QRS, a number of treatment modalities remain open issues. Patient selection criteria need to be further specified, as a broader population can probably benefit from CRT. For instance, several clinical trials are currently addressing the role of CRT in patients with narrow QRS, with mild heart failure (HF) symptoms, or with complete AV block to prevent HF development. But even in those patients who meet current selection criteria, we need to further understand some aspects of the treatment modalities to offer maximum benefit from the therapy: Which location for the right ventricular (RV) and left ventricular (LV) pacing leads offers the best resynchronization? How should CRT parameters (AV and VV delays) be programmed to provide maximum hemodynamic benefit? Answers to these questions are crucial to reduce the number of non-responders to CRT, and to maximize the response to CRT by the majority of patients. In this review we will focus on techniques to optimize CRT programming.


Right Ventricular Cardiac Resynchronization Therapy Mild Heart Failure Right Ventricular Lead Interventricular Delay 
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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Maurizio Lunati
    • 1
  • Yann Poezevara
    • 2
  • Andrea Boncompagni
    • 3
  1. 1.Cardiology Department, Electrophysiology UnitNiguarda Ca’ Granda HospitalMilanItaly
  2. 2.SORIN GroupLes Plessis Robinson CedexFrance
  3. 3.SORIN GroupMilanItaly

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