Medical Treatment of Hemangiomas

  • Jochen Rössler
  • Charlotte Marie Niemeyer


Cytotoxic drugs are a valuable option for the treatment of hemangiomas that interfere with normal functions (vision, breathing, eating, voiding or stooling), result in serious disfigurement, or give rise to ulceration, bleeding, infection, pain, heart and liver failure. Corticosteroids administered systemically are considered first line medical therapy for proliferating hemangiomas. If resistance to corticosteroid treatment is observed or when visceral involvement is present, other cytotoxic drugs such as vincristine or cyclophosphamide can be used. Interferon is effective and was prescribed until recently. However, because of severe neurological toxicity it is increasingly omitted. Here, we summarize the mode of action and side effects as well as the current experience with these drugs used systemically or intra-lesionally.


Obstructive Sleep Apnea Corticosteroid Therapy Interferon Alpha Infantile Hemangioma Hemorrhagic Cystitis 
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Copyright information

© Springer-Verlag Italia 2009

Authors and Affiliations

  • Jochen Rössler
    • 1
  • Charlotte Marie Niemeyer
    • 2
  1. 1.Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent MedicineUniversity Hospital of FreiburgFreiburgGermany
  2. 2.Clinic IV of Pediatric Hematology and Oncology, Centre for PediatricsUniversity of FreiburgFreiburgGermany

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