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Angiogenesis

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Hemangiomas and Vascular Malformations

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Abstract

The vascular system is a complex network of vessels that carries oxygenated blood and nutrients throughout our bodies. It comes as no surprise that angiogenesis, the process of growing new blood vessels, occurs not only in health, but also in serious disease, where it may be either up- or down-regulated. While the growth of the vascular system is one of the earlier events of embryogenesis, angiogenesis also occurs in adulthood, during wound healing and restoration of blood flow to injured tissues. The healthy body controls angiogenesis through a perfect balance of modulators, regulated by a strong interaction between growth factors and inhibitors, the imbalance of which can lead to disease. Angiogenesis is a “common denominator” shared by diseases affecting more than one billion people worldwide; these diseases are caused by both excessive angiogenesis (cancer, diabetic eye disease, rheumatoid arthritis), and insufficient angiogenesis (coronary heart disease, stroke, delayed wound healing) [1].

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Author information

Authors and Affiliations

  1. Hematology-Oncology Laboratory, European Institute of Oncology, Milan, Italy

    Alice Agliano

Authors
  1. Alice Agliano
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Editor information

Editors and Affiliations

  1. Department of Vascular Surgery, Center for Vascular Malformations “Stefan Belov”, “G. Salvini” Hospital, Garbagnate Milanese (Milan), Italy

    Raul Mattassi  & Massimo Vaghi  & 

  2. Center for Circulatory Disturbances and Vascular Defects, Department for Angiology and Vascular Surgery, Facharztklinik Hamburg, Hamburg, Germany

    Dirk A. Loose

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© 2009 Springer-Verlag Italia

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Agliano, A. (2009). Angiogenesis. In: Mattassi, R., Loose, D.A., Vaghi, M. (eds) Hemangiomas and Vascular Malformations. Springer, Milano. https://doi.org/10.1007/978-88-470-0569-3_1

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  • DOI: https://doi.org/10.1007/978-88-470-0569-3_1

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0568-6

  • Online ISBN: 978-88-470-0569-3

  • eBook Packages: MedicineMedicine (R0)

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