Abstract
Surgery is analogous to an extreme stress test. It initiates inflammatory, hypercoagulable, stress, and hypoxic states, which may be associated with elevations in troponin levels leading to postoperative myocardial dysfunction and failure [1]. Cardiac surgery, especially, is associated with the inherent risk of myocardial ischemia and myocardial infarction; and consequently, with postoperative heart failure. The degree of permanent postoperative myocardial injury is determined by the severity and duration of ischemia. A progressive pattern of myocardial dysfunction-apart from ongoing ischemia-suggests that additional underlying mechanisms, which are at least partially different from those of myocardial stunning, may also exist [2].
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References
Devereaux PJ, Goldman L, Cook DJ et al (2005) Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk. CMAJ 173:627–634
Liakopoulos OJ, Muhlfeld C, Koschinsky M et al (2005) Progressive loss of myocardial contractile function despite unimpaired coronary blood flow after cardiac surgery. Basic Res Cardiol 100:75–83
Surgenor SD, O’Connor GT, Lahey SJ et al (2001) Predicting the risk of death from heart failure after coronary artery bypass graft surgery. Anesth Analg 92:596–601
Gardner SC, Grunwald GK, Rumsfeld JS et al (2001) Risk factors for intermediate-term survival after coronary artery bypass grafting. Ann Thorac Surg 72:2033–2037
Royster RL (1993) Myocardial dysfunction following cardiopulmonary bypass: recovery patterns, predictors of inotropic need, theoretical concepts of inotropic administration. J Cardiothorac Vasc Anesth 7:19–25
Khan NE, De Souza A, Mister R et al (2004) A randomized comparison of off-pump and on-pump multivessel coronary-artery bypass surgery. N Engl J Med 350:21–28
Argenziano M, Spotnitz HM, Whang W et al (1999) risk stratification for coronary bypass surgery in patients with left ventricular dysfunction: analysis of the Coronary Artery Bypass Grafting Patch Trial database. Circulation 100:119II–124
Mangano DT (1985) Biventricular function after myocardial revascularization in humans: deterioration and recovery patterns during the first 24 hours. Anesthesiology 62:571–577
Vanky FB, Hakanson E, Tamas E et al (2006) Risk factors for postoperative heart failure in patients operated on for aortic stenosis. Ann Thorac Surg 81:1297–1304
Corin WJ, Sutsch G, Murakami T et al (1995) Left ventricular function in chronic mitral regurgitation: preoperative and postoperative comparison. J Am Coll Cardiol 25:113–121
Slogoff S, Keats AS (1985) Does perioperative myocardial ischemia lead to postoperative myocardial infarction? Anesthesiology 62:107–114
Fillinger MP, Surgenor SD, Hartman GS et al (2002) The association between heart rate and in-hospital mortality after coronary artery bypass graft surgery. Anesth Analg 95:1483–1488
Leung JM, O’Kelly B, Browner WS et al (1989) Prognostic importance of postbypass regional wall-motion abnormalities in patients undergoing coronary artery bypass graft surgery. SPI Research Group. Anesthesiology 71:16–25
Thielmann M, Massoudy P, Neuhauser M et al (2006) Prognostic value of preoperative cardiac troponin I in patients undergoing emergency coronary artery bypass surgery with non-ST-elevation or ST-elevation acute coronary syndromes. Circulation 114: I448–I453
Kirklin JW, Conti VR, Blackstone EH (1979) Prevention of myocardial damage during cardiac operations. N Engl J Med 301:135–141
Kay HR, Levine FH, Fallon JT et al (1978) Effect of cross-clamp time, temperature, and cardioplegic agents on myocardial function after induced arrest. J Thorac Cardiovasc Surg 76:590–603
Fremes SE, Tamariz MG, Abramov D et al (2000) Late results of the Warm Heart Trial: the influence of nonfatal cardiac events on late survival. Circulation 102:339III–345
Fukunami M, Hearse DJ (1989) The inotropic consequences of cooling: studies in the isolated rat heart. Heart Vessels 5:1–9
Guru V, Omura J, Alghamdi AA et al (2006) Is blood superior to crystalloid cardioplegia?: a meta-analysis of randomized clinical trials. Circulation 114: I-331
Banach M, Rysz J, Drozdz JA et al (2006) Risk factors of atrial fibrillation following coronary artery bypass grafting: a preliminary report. Circ J 70:438–441
Tripp HF, Bolton JW (1998) Phrenic nerve injury following cardiac surgery: a review. J Card Surg 13:218–223
Kevin LG, Novalija E, Stowe DF (2005) Reactive oxygen species as mediators of cardiac injury and protection: the relevance to anesthesia practice. Anesth Analg 101:1275–1287
Kloner RA, Jennings RB. (2001) Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: Part 1. Circulation 104:2981–2989
Casthely PA, Shah C, Mekhjian H et al (1997) Left ventricular diastolic function after coronary artery bypass grafting: a correlative study with three different myocardial protection techniques. J Thorac Cardiovasc Surg 114:254–260
Glavind-Kristensen M, Brix-Christensen V, Toennesen E et al (2002) Pulmonary endothelial dysfunction after cardiopulmonary bypass in neonatal pigs. Acta Anaesthesiol Scand 46:853–859
Toller WG, Kersten JR, Pagel PS et al (1999) Sevoflurane reduces myocardial infarct size and decreases the time threshold for ischemic preconditioning in dogs. Anesthesiology 91:1437–1446
De Hert SG, Van der Linden PJ, Cromheecke S et al (2004) Cardioprotective properties of sevoflurane in patients undergoing coronary surgery with cardiopulmonary bypass are related to the modalities of its administration. Anesthesiology 101:299–310
Conzen PF, Fischer S, Detter C et al (2003) Sevoflurane provides greater protection of the myocardium than propofol in patients undergoing off-pump coronary artery bypass surgery. Anesthesiology 99:826–833
Nader ND, Li CM, Khadra WZ et al (2004) Anesthetic myocardial protection with sevoflurane. J Cardiothorac Vasc Anesth 18:269–274
Mangano DT, Layug EL, Wallace A et al (1996) Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. N Engl J Med 335:1713–1721
Fleisher LA, Beckman JA, Brown KA et al (2006) ACC/AHA 2006 Guideline update on perioperative cardiovascular evaluation for noncardiac surgery: focused update on perioperative beta-blocker therapy: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). Circulation 113:2662–2674
Giles JW, Sear JW and Foex P. (2004) Effect of chronic beta-blockade on peri-operative outcome in patients undergoing non-cardiac surgery: an analysis of observational and case control studies. Anaesthesia 59:574–583
Nette AF, Abraham G, Ungemach FR et al (2005) Interaction between simvastatin and metoprolol with respect to cardiac beta-adrenoceptor density, catecholamine levels and perioperative catecholamine requirements in cardiac surgery patients. Naunyn Schmiedebergs Arch Pharmacol 372:115–124
Poldermans D, Boersma E, Bax JJ et al (1999) The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. N Engl J Med 341:1789–1794
Akhtar S, Amin M, Tantawy H et al (2005) Preoperative beta-blocker use: is titration to a heart rate of 60 beats per minute a consistently attainable goal? J Clin Anesth 17:191–197
Ferguson TB Jr, Coombs LP, Peterson ED (2002) Preoperative beta-blocker use and mortality and morbidity following CABG surgery in North America. JAMA 287:2221–2227
ten Broecke PWC, De Hert SG, Mertens E et al (2003) Effect of preoperative ?-blockade on perioperative mortality in coronary surgery. Br J Anaesth 90:27–31
Toller WG, Stranz C (2006) Levosimendan, a new inotropic and vasodilator agent. Anesthesiology 104:556–569
Follath F, Cleland JG, Just H et al (2002) Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial. Lancet 360:196–202
Morelli A, Teboul JL, Maggiore SM et al (2006) Effects of levosimendan on right ventricular afterload in patients with acute respiratory distress syndrome: a pilot study. Crit Care Med 34:2287–2293
Al-Shawaf E, Ayed A, Vislocky I et al (2006) Levosimendan or milrinone in the type 2 diabetic patient with low ejection fraction undergoing elective coronary artery surgery. J Cardiothorac Vasc Anesth 20:353–357
Sonntag S, Sundberg S, Lehtonen LA et al (2004) The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia. J Am Coll Cardiol 43:2177–2182
Barisin S, Husedzinovic I, Sonicki Z et al (2004) Levosimendan in off-pump coronary artery bypass: a four-times masked controlled study. J Cardiovasc Pharmacol 44:703–708
Nijhawan N, Nicolosi AC, Montgomery MW et al (1999) Levosimendan enhances cardiac performance after cardiopulmonary bypass: a prospective, randomized placebo-controlled trial. J Cardiovasc Pharmacol 34:219–228
Tritapepe L, De S, V, Vitale D et al (2006) Preconditioning effects of levosimendan in coronary artery bypass grafting-a pilot study. Br J Anaesth 96:694–700
Christenson JT, Cohen M (2002) Preoperative IABP in high-risk patients reduces postoperative lactate release and subsequent mortality. Ann Thorac Surg 73:1026–1027
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Moosbauer, W., Hofer, A., Gombotz, H. (2007). Prevention and Management of Cardiac Dysfunction during and after Cardiac Surgery. In: Perioperative Critical Care Cardiology. Topics in Anaesthesia and Critical Care. Springer, Milano. https://doi.org/10.1007/978-88-470-0558-7_14
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DOI: https://doi.org/10.1007/978-88-470-0558-7_14
Publisher Name: Springer, Milano
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