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Anti-TNF-α Antibody and Cancer Cachexia

  • Mark de Witte
  • Mark Anderson
  • Don Robinson

Abstract

Cachexia is characterised by accelerated loss of adipose tissue and skeletal muscle in the context of a chronic inflammatory response [1] [3]. It is a common complication of advanced cancer [4]. About half of all cancer patients suffer from this syndrome, which is among the most debilitating and life-threatening complications [5]. The key feature of this syndrome is weight loss, but other symptoms, such as anorexia, fatigue, vomiting and anaemia, and accelerated malnutrition with depletion of whole-body lipid and protein stores are frequently observed. Cancer cachexia contributes to immobility, a propensity to infection, shortened duration of survival, and overall decreased quality of life [6].

Keywords

Lean Body Mass Cancer Cachexia Hairy Cell Leukaemia Isolate Limb Perfusion Hairy Cell Leukaemia Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • Mark de Witte
    • 1
  • Mark Anderson
    • 1
  • Don Robinson
    • 1
  1. 1.Clinical Hematology/Oncology, CentocorMalvernUSA

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