COX-2 Inhibitors in Cancer Cachexia

  • Giovanni Mantovani


Cyclo-oxygenase-2 (COX-2) is an enzyme catalysing the synthesis of prostaglandins (PGs) from arachidonic acid. Cells contain genes coding for two isoforms of COX (COX-1 and COX-2). COX-1 is expressed constitutively in most tissues and appears to be responsible for the production of PGs that mediate normal physiological functions, such as maintenance of the integrity of the gastric mucosa and regulation of renal blood flow. In contrast, COX-2 is undetectable in most normal tissues: it is induced by cytokines, growth factors, oncogenes and tumour promoters, and it contributes to the synthesis of PGs in inflamed and neoplastic tissues [1]. COX-2 is induced in many human tumours and is associated with aberrant angiogenesis in a number of pathological settings, especially those involving inflammation. It has been well demonstrated that dysregulation of COX-2 expression correlates with development of gastrointestinal cancers.


Cancer Cachexia Indomethacin Treatment Advanced Lung Adenocarcinoma Prostaglandin Leukot Essent Fatty Acid Aberrant Angiogenesis 
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Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • Giovanni Mantovani
    • 1
  1. 1.Department of Medical OncologyUniversity of CagliariCagliariItaly

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