Abstract
Cancer cachexia (CC) is probably the most debilitating and life-threatening paraneoplastic syndrome. It is characterised by weight loss, anorexia, asthaenia, loss of skeletal muscle protein, depletion of lipid stores, and severe metabolic alterations. CC syndrome is present in about 50% of cancer patients, especially those with tumours of the gastrointestinal tract and lung, and less frequently in those with haematological malignancies and other solid neoplasms, such as breast and thyroid cancer. The majority of terminally ill cancer patients experiences CC, which accounts for about 20% of cancer deaths. This figure translates into approximately 2000000 deaths per year worldwide [1].
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© 2006 Springer-Verlag Italia
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Muscaritoli, M., Bossola, M., Doglietto, G.B., Fanelli, F.R. (2006). The Ubiquitin/Proteasome System in Cancer Cachexia. In: Mantovani, G., et al. Cachexia and Wasting: A Modern Approach. Springer, Milano. https://doi.org/10.1007/978-88-470-0552-5_48
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DOI: https://doi.org/10.1007/978-88-470-0552-5_48
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0471-9
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