The Ubiquitin/Proteasome System in Cancer Cachexia

  • Maurizio Muscaritoli
  • Maurizio Bossola
  • Giovanni Battista Doglietto
  • Filippo Rossi Fanelli


Cancer cachexia (CC) is probably the most debilitating and life-threatening paraneoplastic syndrome. It is characterised by weight loss, anorexia, asthaenia, loss of skeletal muscle protein, depletion of lipid stores, and severe metabolic alterations. CC syndrome is present in about 50% of cancer patients, especially those with tumours of the gastrointestinal tract and lung, and less frequently in those with haematological malignancies and other solid neoplasms, such as breast and thyroid cancer. The majority of terminally ill cancer patients experiences CC, which accounts for about 20% of cancer deaths. This figure translates into approximately 2000000 deaths per year worldwide [1].


Gastric Cancer Gastric Cancer Patient Muscle Atrophy Cancer Cachexia Proteolytic Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Italia 2006

Authors and Affiliations

  • Maurizio Muscaritoli
    • 1
  • Maurizio Bossola
    • 2
  • Giovanni Battista Doglietto
    • 2
  • Filippo Rossi Fanelli
    • 1
  1. 1.Department of Clinical MedicineUniversity of Rome La SapienzaRomeItaly
  2. 2.Department of SurgeryThe Catholic University of RomeRomeItaly

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