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Dietary Intake, Resting Energy Expenditure, Weight Loss, and Survival in Cancer Patients

  • Kent Lundholm
  • Ingvar Bosaeus

Abstract

Weight loss is frequently seen in patients with advanced cancer and has long been recognised to be associated with decreased survival [1]. Cancer cachexia is a complex syndrome depending on cytokines, eicosanoids, and classical hormones, and characterised by progressive weight loss with depletion of host reserves of skeletal muscle and adipose tissue. It is the net result of profound metabolic changes that appear in patients with advanced stages of cancer, and is characterised by net breakdown of skeletal muscle and alterations in fat and carbohydrate metabolism. Cachexia is the most common paraneoplastic syndrome, and is also referred to as the cancer anorexia-cachexia syndrome, with features of anorexia, early satiety, weakness, and fatigue.

Keywords

Energy Intake Lung Cancer Patient Total Energy Expenditure Cancer Cachexia Rest Energy Expenditure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Dewys WD, Begg C, Lavin PT et al (1980) Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med 69:491–497PubMedCrossRefGoogle Scholar
  2. 2.
    Bosaeus I, Daneryd P, Svanberg E et al (2001) Dietary intake and resting energy expenditure in relation to weight loss in cancer patients. Int J Cancer 93:380–383PubMedCrossRefGoogle Scholar
  3. 3.
    Baracos VE (2002) Hypercatabolism and hypermetabolism in wasting states. Curr Opin Clin Nutr Metab Care 5:237–239PubMedCrossRefGoogle Scholar
  4. 4.
    Cohn SH, Gartenhaus W. Vartsky D et al (1981) Body composition and dietary intake in neoplastic disease. Am J Clin Nutr 34:1997–2004PubMedGoogle Scholar
  5. 5.
    Parkinson SA, Lewis J, Morris R et al (1987) Oral protein and energy supplements in cancer patients. Hum Nutr Appl Nutr 41:233–243PubMedGoogle Scholar
  6. 6.
    Simons JP, Schols AM, Hoefnagels JM et al (1998) Effects of medroxyprogesterone acetate on food intake, body composition, and resting energy expenditure in patients with advanced, nonhormone-sensitive cancer: a randomized, placebo-controlled trial. Cancer 82:553–560PubMedCrossRefGoogle Scholar
  7. 7.
    Staalvan den Brekel AJ, Schols AM, ten Velde GP et al (1994) Analysis of the energy balance in lung cancer patients. Cancer Res 54:6430–6433Google Scholar
  8. 8.
    Wigmore SJ, Plester CE, Ross JA et al (1997) Contribution of anorexia and hypermetabolism to weight loss in anicteric patients with pancreatic cancer. Br J Surg 84:196–197PubMedCrossRefGoogle Scholar
  9. 9.
    Levine JA, Morgan MY (1998) Preservation of macronutrient preferences in cancer anorexia. Br J Cancer 78:579–581PubMedGoogle Scholar
  10. 10.
    Fordy C, Glover C, Henderson DC et al (1999) Contribution of diet, tumour volume and patient-related factors to weight loss in patients with colorectal liver métastases. Br J Surg 86:639–644PubMedCrossRefGoogle Scholar
  11. 11.
    Lundholm K, Edstrom S, Karlberg I et al (1982) Glucose turnover, gluconeogenesis from glycerol,and estimation of net glucose cycling in cancer patients. Cancer 50:1142–1150PubMedCrossRefGoogle Scholar
  12. 12.
    Warnold I, Lundholm K, Schersten T (1978) Energy balance and body composition in cancer patients. Cancer Res 38:1801–1807PubMedGoogle Scholar
  13. 13.
    Bozzetti F, Pagnoni AM, Del Vecchio M (1980) Excessive caloric expenditure as a cause of malnutrition in patients with cancer. Surg Gynecol Obstet 150:229–234PubMedGoogle Scholar
  14. 14.
    Hyltander A, Drott C, Korner U et al (1991) Elevated energy expenditure in cancer patients with solid tumours. Eur J Cancer 27:9–15PubMedCrossRefGoogle Scholar
  15. 15.
    Dempsey DT, Feurer ID, Knox LS et al (1984) Energy expenditure in malnourished gastrointestinal cancer patients. Cancer 53:1265–1273PubMedCrossRefGoogle Scholar
  16. 16.
    Knox LS, Crosby LO, Feurer IDetal (1983) Energyexpenditure in malnourished cancer patients. Ann Surg 197:152–162PubMedCrossRefGoogle Scholar
  17. 17.
    Barber MD, Ross JA, Fearon KC (1999) Cancer cachexia. Surg Oncol 8:133–141PubMedCrossRefGoogle Scholar
  18. 18.
    Tisdale MJ (2002) Cachexia in cancer patients. Nat Rev Cancer 2:862–871PubMedCrossRefGoogle Scholar
  19. 19.
    Zylicz Z, Schwantje O, Wagener DJ et al (1990) Metabolic response to enterai food in different phases of cancer cachexia in rats. Oncology 47:87–91PubMedCrossRefGoogle Scholar
  20. 20.
    Jatoi A, Daly BD, Hughes V et al (1999) The prognostic effect of increased resting energy expenditure prior to treatment for lung cancer. Lung Cancer 23:153–158PubMedCrossRefGoogle Scholar
  21. 21.
    Hyltander A, Korner U, Lundholm KG (1993) Evaluation of mechanisms behind elevated energy expenditure in cancer patients with solid tumours. Eur J Clin Invest 23:46–52PubMedCrossRefGoogle Scholar
  22. 22.
    Drott C, Svaninger G, Lundholm K (1988) Increased urinary excretion of cortisol and catecholamines in malnourished cancer patients. Ann Surg 208:645–650PubMedCrossRefGoogle Scholar
  23. 23.
    Drott C, Persson H, Lundholm K (1989) Cardiovascular and metabolic response to adrenaline infusion in weightlosing patients with and without cancer. Clin Physiol 9:427–439PubMedGoogle Scholar
  24. 24.
    Lundholm K, Daneryd P, Korner U et al (2004) Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia. Int J Oncol 24:505–512PubMedGoogle Scholar
  25. 25.
    Lindmark L, Bennegard K, Eden E et al (1986) Thermic effect and substrate oxidation in response to intravenous nutrition in cancer patients who lose weight. Ann Surg 204:628–636PubMedCrossRefGoogle Scholar
  26. 26.
    Moses AW, Slater C, Preston T et al (2004) Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids. Br J Cancer 90:996–1002PubMedCrossRefGoogle Scholar
  27. 27.
    Jatoi A, Hillman S, Stella PJ et al (2003) Daily activities: exploring their spectrum and prognostic impact in older, chemotherapy-treated lung cancer patients. Support Care Cancer 11:460–464PubMedCrossRefGoogle Scholar
  28. 28.
    Gibney E, Elia M, Jebb SA et al (1997) Total energy expenditure in patients with small-cell lung cancer: results of a validated study using the bicarbonate-urea method. Metabolism 46:1412–1417PubMedCrossRefGoogle Scholar
  29. 29.
    Anonymous (1989) Parenteral nutrition in patients receiving cancer chemotherapy. American College of Physicians. Ann Intern Med 110:734–736Google Scholar
  30. 30.
    Bruera E, Macmillan K, Kuehn N et al (1990) A controlled trial of megestrol acetate on appetite, caloric intake, nutritional status, and other symptoms in patients with advanced cancer. Cancer 66:1279–1282PubMedCrossRefGoogle Scholar
  31. 31.
    Lundholm K, Gelin J, Hyltander A et al (1994) Anti-inflammatory treatment may prolong survival in undernourished patients with metastatic solid tumors. Cancer Res 54:5602–5606PubMedGoogle Scholar
  32. 32.
    Lundholm K, Daneryd P, Bosaeus I et al (2004) Palliative nutritional intervention in addition to cyclooxygenase and erythropoietin treatment for patients with malignant disease: effects on survival, metabolism and function. A randomized prospective study. Cancer 100:1967–1977PubMedCrossRefGoogle Scholar
  33. 33.
    Fearon KC, Von Meyenfeldt MF, Moses AG et al (2003) Effect of a protein and energy dense N-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial. Gut 52:1479–1486PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • Kent Lundholm
    • 1
  • Ingvar Bosaeus
    • 2
  1. 1.Department of SurgeryGöteborg University, Sahlgrenska University HospitalGöteborgSweden
  2. 2.Clinical Nutrition, Göteborg University, Sahlgrenska University HospitalGöteborgSweden

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