Abstract
During disease, a formidable biological fight occurs between invading cells and the defending host.As a consequence, both sides use all the available weapons to succeed: invaders will try to shut off the host defence systems while the host will try to isolate and destroy the invaders. Metabolic perturbations inevitably develop and, if the challenge is prolonged over time, changes in body composition occur. Thus, cachexia could be considered as ‘collateral damage’ in the fight between invading cells and the defending host.
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References
Tisdale MJ (2001) Cancer anorexia and cachexia. Nutrition 17:438–442
Shaw JH, Wolfe RR (1987) Fatty acid and glycerol kinetics in septic patients and in patients with gastrointestinal cancer. The response to glucose infusion and parenteral feeding. Ann Surg 205:368–376
Drott C, Persson H, Lundholm K (1989) Cardiovascular and metabolic response to adrenaline infusion in weight-losing patients with and without cancer. Clin Physiol 9:427–439
Edmonson JH (1966) Fatty acid mobilization and glucose metabolism in patients with cancer. Cancer 19:277–280
Costa G, Bewley P, Aragon M, Siebold J (1981) Anorexia and weight loss in cancer patients. Cancer Treat Rep 65(Suppl 5):3–7
Groundwater P, Beck SA, Barton C et al (1990) Alteration of serum and urinary lipolytic activity with weight loss in cachectic cancer patients. Br J Cancer 62:816–821
Beck SA, Tisdale MJ (1987) Production of lipolytic and proteolytic factors by a murine tumor producing cachexia in the host. Cancer Res 47:5919–5923
Khan S, Tisdale MJ (1999) Catabolism of adipose tissue by a tumour-produced lipid-mobilising factor. Int J Cancer 80:444–447
Berg M, Fraker DL, Alexander HR (1994) Characterization of differentiation factor/leukaemia inhibitory factor effect on lipoprotein lipase activity and mRNA in 3T3-LI adipocytes. Cytokine 6:425–432
Thompson MP, Cooper ST, Parry BR, Tuckey JA (1993) Increased expression of the mRNA for the hormone-sensitive lipase in adipose tissue of cancer patients. Biochim Biophys Acta 1180:236–242
Todorov PT, McDevitt TM, Meyer DJ et al (1998) Purification and characterization of a tumour lipidmobilizing factor. Cancer Res 58:2353–2358
Hirai K, Hussey HJ, Barber MD et al (1998) Biological evaluation of a lipid-mobilizing factor isolated from the urine of cancer patients. Cancer Res 58:2359–2365
Bing C, Brown M, King P et al (2000) Increased gene expression of brown fat UCP1 and skeletal muscle UCP2 and UCP3 in MAC16-induced cancer cachexia. Cancer Res 60:2405–2410
Fredrix EW, Soeters PB, Wouters EF et al (1991) Effect of different tumor types on resting energy expenditure. Cancer Res 51:6138–6141
Falconer JS, Fearon KC, Plester CE et al (1994) Cytokines, the acute-phase response, and resting energy expenditure in cachectic patients with pancreatic cancer. Ann Surg 219:325–331
Gambardella A, Tortoriello R, Pesce L et al (1999) Intralipid infusion combined with propranolol administration has favourable metabolic effects in elderly malnourished cancer patients. Metabolism 48:291–297
Lowell BB, Flier JS (1997) Brown adipose tissue, beta 3-adrenergic receptors and obesity. Ann Rev Med Chem 48:307–316
Hyltander A, Daneryd P, Sandstrom R et al (2000) b-Adrenoceptor activity and resting energy metabolism in weight losing cancer patients. Eur J Cancer 36:330–334
Russell ST, Hirai K, Tisdale MJ (2002) Role of b3-adrenergic receptors in the action of a tumour lipid mobilizing factor. Br J Cancer 86:424–428
Islam-Ali B, Khan S, Price SA, Tisdale MJ (2001) Modulation of adipocyte G-protein expression in cancer cachexia by a lipid-mobilizing factor (LMF). Br J Cancer 85:758–763
Bing C, Bao Y, Jenkins J et al (2004) Zinc-a2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia. Proc Natl Acad Sci USA 101:2500–2505
Gohda T, Makita Y, Shike T et al (2003) Identification of epistatic interaction involved in obesity using the KK/Ta mouse as a type 2 diabetes model: is Znalpha2 glycoprotein-1 a candidate gene for obesity? Diabetes 52: 2175–2181
Islam-Ali BS, Tisdale MJ (2001) Effect of a tumourproduced lipid-mobilizing factor on protein synthesis and degradation. Br J Cancer 84:1648–1655
Bing C, Russell ST, Beckett EE et al (2002) Expression of uncoupling proteins-1,-2 and-3 mRNA is induced by an adenocarcinoma-derived lipid-mobilizing factor. Br J Cancer 86:612–618
Russell ST, Tisdale MJ (2002) Effect of tumour-derived lipid-mobilising factor on glucose and lipid metabolism in vivo. Br J Cancer 87:580–584
Sanders PM, Tisdale MJ (2004) Role of lipid-mobilising factor (LMF) in protecting tumour cells from oxidative damage. Br J Cancer 90:1274–1278
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© 2006 Springer-Verlag Italia
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Laviano, A., Muscaritoli, M., Fanelli, F.R. (2006). Lipid Mobilising Factor in Cancer Cachexi. In: Mantovani, G., et al. Cachexia and Wasting: A Modern Approach. Springer, Milano. https://doi.org/10.1007/978-88-470-0552-5_46
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DOI: https://doi.org/10.1007/978-88-470-0552-5_46
Publisher Name: Springer, Milano
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