The Pharmacokinetics and Pharmacodynamics of Drugs in Elderly Cachectic (Cancer) Patients

  • Dario Cova
  • Vito Lorusso
  • Nicola Silvestris


The word cachexia is derived from the Greek words kakòs, meaning ‘bad,’ and hexis, meaning ‘condition’ [1]. From an epidemiological point of view, while patients with haematological malignancies and breast cancer seldom have this syndrome, most other solid tumours are associated with a high frequency of cachexia [2]. Indeed, its prevalence increases from 50% to more than 80% before death, and in more than 20% of patients cachexia is the main cause of death [3].


Glomerular Filtration Rate Atrophic Gastritis Vinca Alkaloid Elderly Cancer Patient Cachectic Patient 
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Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • Dario Cova
    • 1
  • Vito Lorusso
    • 2
  • Nicola Silvestris
    • 3
  1. 1.Onco-Geriatric Unit, Pio Albergo Trivulzio Institute,Milan, Italy and Geropharmacological Pharmacosurveillance Center, Department of PharmacologyUniversity of MilanMilanItaly
  2. 2.Medical Oncology UnitIRCCS Oncology InstituteBariItaly
  3. 3.Medical Oncology UnitGiorgio Porfiri Oncology Center, Hospital of LatinaLatinaItaly

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