Endocrine Disorders

  • Laura Gianotti
  • Andrea Picu
  • Fabio Lanfranco
  • Francesco Tassone
  • Matteo Baldi
  • Roberta Giordano
  • Ezio Ghigo
  • Mauro Maccario


Body weight is determined by the complex interaction of caloric intake, absorption and utilisation of nutrients. Multiple factors (age, health status, neural, hormonal and metabolic influences, and medications) influence this interaction. The major site of this integration is represented by the hypothalamic area, where complex and specific neural circuits receive feedback from peripheral signals and coordinate the response in terms of stimulation or inhibition of food intake and energy balance [1] [3]. Among these peripheral signals, the adipocyte-derived hormone leptin informs the brain regarding the need to inhibit food intake and limit fat accumulation [4, 5]. In contrast, the gastric hormone ghrelin (see chapter by Broglio et al.) induces a sensation of hunger and is involved in energy homeostasis by inducing the storage of fat in adipose tissue [6].


Celiac Disease Anorexia Nervosa Adrenal Insufficiency Chromaffin Cell Islet Cell Tumour 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • Laura Gianotti
    • 1
  • Andrea Picu
    • 2
  • Fabio Lanfranco
    • 2
  • Francesco Tassone
    • 2
  • Matteo Baldi
    • 2
  • Roberta Giordano
    • 2
  • Ezio Ghigo
    • 2
  • Mauro Maccario
    • 2
  1. 1.Department of Internal Medicine, Division of Endocrinology and MetabolismUniversity of TurinTurinItaly
  2. 2.Department of Internal Medicine, Division of EndocrinologyUniversity of TurinTurinItaly

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