Brain Mechanisms in Wasting and Cachexia

  • Carlos R. Plata-Salaman


As summarised in previous chapters, chronic (neoplastic, necrotic, infectious) pathophysiological processes of various systems are frequently accompanied by wasting and cachexia. The pathophysiology of wasting and cachexia is complex [1] [10] and multiple brain mechanisms [11] [13] can be involved including neurological, psychiatric, psychological, physiological, biochemical/ metabolic, immunological, and chemical per se (e.g. neurotransmitter-, neuropeptideand cytokine-related). These mechanisms can interact/synergise with peripheral/systemic processes or dysfunctions (e.g. gastrointestinal malabsorption and body losses such as via ulcers, effusions, haemorrhage).


Cancer Cachexia Brain Mechanism Circumventricular Organ Melanocortin System Central Nervous System Response 


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Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • Carlos R. Plata-Salaman
    • 1
  1. 1.Global External Research & Development, Lilly Research LaboratoriesLilly Corporate CenterIndianapolisUSA

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