Leptin and Des-acyl Ghrelin: Their Role in Physiological Body Weight Regulation and in the Pathological State

  • Simona Perboni
  • Giovanni Mantovani
  • Akio Inui


Obesity, eating disorders and cachexia endanger the lives of millions of people worldwide. Fortunately, during the past decade, there has been a rapid and substantial progress toward uncovering the molecular and neural mechanisms by which energy imbalance develops. Central to this research has been the identification and characterisation of certain peripheral metabolic signals, such as leptin and ghrelin, which serve as fundamental indices of energy sufficiency [1].


Arcuate Nucleus Acyl Ghrelin Growth Hormone Secretagogue Receptor POMC Neuron Orexin Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • Simona Perboni
    • 1
  • Giovanni Mantovani
    • 1
  • Akio Inui
    • 2
  1. 1.Department of Medical OncologyUniversity of CagliariCagliariItaly
  2. 2.Department of Behavioral MedicineKagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan

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