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Leptin and Des-acyl Ghrelin: Their Role in Physiological Body Weight Regulation and in the Pathological State

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Cachexia and Wasting: A Modern Approach

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Abstract

Obesity, eating disorders and cachexia endanger the lives of millions of people worldwide. Fortunately, during the past decade, there has been a rapid and substantial progress toward uncovering the molecular and neural mechanisms by which energy imbalance develops. Central to this research has been the identification and characterisation of certain peripheral metabolic signals, such as leptin and ghrelin, which serve as fundamental indices of energy sufficiency [1].

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Authors and Affiliations

  1. Department of Medical Oncology, University of Cagliari, Cagliari, Italy

    Simona Perboni & Giovanni Mantovani

  2. Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

    Akio Inui

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  1. Simona Perboni
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  2. Giovanni Mantovani
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  3. Akio Inui
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Editor information

Editors and Affiliations

  1. Department of Medical Oncology, University of Cagliari, Cagliari, Italy

    Giovanni Mantovani

  2. Department of Clinical Cardiology, Imperial College, NHLI, London, UK

    Stefan D. Anker

  3. Department of Cardiology Charité, Applied Cachexia Research, Campus Virchow-Klinikum, Berlin, Germany

    Stefan D. Anker

  4. Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

    Akio Inui

  5. GRECC, VA Medical Center and Division of Geriatric Medicine, Saint Louis University, St. Louis, MO, USA

    John E. Morley

  6. Department of Clinical Medicine, University of Rome, La Sapienza, Rome, Italy

    Filippo Rossi Fanelli

  7. Department of Infectious Diseases, IRCCS S.Matteo Polyclinic, University of Pavia, Pavia, Italy

    Daniele Scevola

  8. Bone Marrow and Blood Stem Cell Transplantation Program, Center for Lymphoma and Myeloma, New York Presbyterian Hospital/Weill Medical Center, New York, NY, USA

    Michael W. Schuster

  9. Department of Medicine-Geriatrics, University of New York at Stony Brook VAMC, Northport, NY, USA

    Shing-Shing Yeh

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Perboni, S., Mantovani, G., Inui, A. (2006). Leptin and Des-acyl Ghrelin: Their Role in Physiological Body Weight Regulation and in the Pathological State. In: Mantovani, G., et al. Cachexia and Wasting: A Modern Approach. Springer, Milano. https://doi.org/10.1007/978-88-470-0552-5_25

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  • DOI: https://doi.org/10.1007/978-88-470-0552-5_25

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