Cytokines in Cachexia

  • Giovanni Mantovani


Tissue damage is a threat to well-being because it is self-promoting; that is, hydrolases released from inflammatory or injured cells cause further injury and provide substrate for formation and propagation of free radicals. For this reason, the body must localise and limit the injury and clear tissue debris. To perform these functions, the organism has developed an acute-phase response that includes stereotyped, coordinated adaptations ranging from behavioural to physiological [1]. The acute-phase response includes the hepatic synthesis of large quantities of proteins. The functions of the acute-phase proteins vary widely and include binding proteins (opsonins), protease inhibitors, complement factors, apoproteins, fibrinogen, and others.


Chronic Obstruc Tive Pulmonary Disease Leukocytic Pyrogen Altered Gastric Emptying Serum Lipid Concen 


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Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • Giovanni Mantovani
    • 1
  1. 1.Department of Medical OncologyUniversity of CagliariCagliariItaly

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