Immunological Parameters of Nutrition

  • Clelia Madeddu
  • Giovanni Mantovani


The interdependency between nutrition and immune function was recognised formally in the 1970s when immunological measures were introduced as part of the assessment of nutritional status [1]. Both the nutritional status and specific nutrients may affect the immune system directly (e.g., by triggering immune cell activation or altering immune cell interactions) or indirectly (e.g., by changing substrates for DNA synthesis, altering energy metabolism, changing the physiological integrity of cells, or altering signals or hormones) [2]. Protein-energy malnutrition is accepted as a major cause of immune deficiency worldwide, and the immune response is considered integral to the pathophysiology of many chronic diseases [3]. Protein-energy malnutrition is associated with a significant impairment of cellmediated immunity, phagocyte function, complement system, secretory immunoglobulin A antibody concentrations and cytokine production.


Immunological Parameter Nutrient Modulation Biotin Deficiency Modern Nutrition Adipose Tissue Lipoprotein Lipase Activ 
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Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • Clelia Madeddu
    • 1
  • Giovanni Mantovani
    • 1
  1. 1.Department of Medical OncologyUniversity of CagliariCagliariItaly

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