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Immunological Parameters of Nutrition

  • Clelia Madeddu
  • Giovanni Mantovani

Abstract

The interdependency between nutrition and immune function was recognised formally in the 1970s when immunological measures were introduced as part of the assessment of nutritional status [1]. Both the nutritional status and specific nutrients may affect the immune system directly (e.g., by triggering immune cell activation or altering immune cell interactions) or indirectly (e.g., by changing substrates for DNA synthesis, altering energy metabolism, changing the physiological integrity of cells, or altering signals or hormones) [2]. Protein-energy malnutrition is accepted as a major cause of immune deficiency worldwide, and the immune response is considered integral to the pathophysiology of many chronic diseases [3]. Protein-energy malnutrition is associated with a significant impairment of cellmediated immunity, phagocyte function, complement system, secretory immunoglobulin A antibody concentrations and cytokine production.

Keywords

Immunological Parameter Nutrient Modulation Biotin Deficiency Modern Nutrition Adipose Tissue Lipoprotein Lipase Activ 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bistrian BR, Blackburn GL, Sherman M et al (1975) Therapeutic index of nutritional depletion in hospitalized patients. Surg Gynecol Obstet 141:512–516PubMedGoogle Scholar
  2. 2.
    Field CJ (2000) Use of T cell function to determine the effect of physiologically active food components. Am J Clin Nutr 71:1720S–1725SPubMedGoogle Scholar
  3. 3.
    Romagnani S (1994) Lymphokine production by human T cells in disease states. Annu Rev Immunol 12:227–257PubMedCrossRefGoogle Scholar
  4. 4.
    Chandra RK (2002) Nutrition and the immune system from birth to old age. Eur J Clin Nutr 56:S73–S76PubMedCrossRefGoogle Scholar
  5. 5.
    Roubenoff R (1997) Inflammatory and hormonal mediators of cachexia. J Nutr 127:1014S–1016SPubMedGoogle Scholar
  6. 6.
    Chandra RK (1997) Graying of the immune system: can nutrient supplements improve immunity in the elderly? JAMA 277:1398–1399PubMedCrossRefGoogle Scholar
  7. 7.
    Nossal GJV (1993) Life, death and the immune system. Sci Am 269:52–64PubMedCrossRefGoogle Scholar
  8. 8.
    Field CJ (1996) Using immunological techniques to determine the effect of nutrition on T-cell function. Can J Physiol Pharmacol 74:769–777PubMedCrossRefGoogle Scholar
  9. 9.
    Pomposelli JJ, Flores EA, Bistrian BR (1988) Role of biochemical mediators in clinical nutrition and surgical metabolism. JPEN J Parenter Enterai Nutr 12:212–218Google Scholar
  10. 10.
    Kushner I (1993) Regulation of the acute phase response by cytokines. Perspect Biol Med 36:611–622PubMedGoogle Scholar
  11. 11.
    Klasing KC (1988) Nutritional aspects of leukocytic cytokines. J Nutr 118:1436–1446PubMedGoogle Scholar
  12. 12.
    Fong Y, Lowry SF (1996) Cytokines and the cellular response to injury and infection. In: Harken AH, Wilmore DW (eds) Care of the surgical patient. Sci Am (Suppl), pp 1–21Google Scholar
  13. 13.
    Smith MK, Lowry SF (1998) The hypercatabolic state. In: Shils ME, Olson JA, Shike M, Ross AC (eds) Modern nutrition in health and disease, 9th ed. Williams and Wilkins, Baltimore, pp 1555–1568Google Scholar
  14. 14.
    Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87–91PubMedCrossRefGoogle Scholar
  15. 15.
    Carswell EA, Old LJ, Kassel RL et al (1975) An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA 72:3666–3670PubMedCrossRefGoogle Scholar
  16. 16.
    Tracey KJ, Cerami A (1993) Tumor necrosis factor, other cytokines and disease. Annu Rev Cell Biol 9:317–343PubMedCrossRefGoogle Scholar
  17. 17.
    Fong Y, Lowry SF (1993) Metabolic consequences of critical illness. In: Barie PS, Shires GT (eds) Surgical intensive care, vol 1. Little, Brown and Co, Boston, pp 893–905Google Scholar
  18. 18.
    Finck BN, Johnson RW (2000) Tumor necrosis factor-alpha regulates secretion of the adipocytederived cytokine, leptin. Microsc Res Tech 50:209–215PubMedCrossRefGoogle Scholar
  19. 19.
    Oliff A, Defeo-Jones D, Boyer M et al (1987) Tumors secreting human TNF/cachectin induce cachexia in mice. Cell 50:555–563PubMedCrossRefGoogle Scholar
  20. 20.
    Van der Poll T, Romijn JA, Endert E et al (1991) Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans. Am J Physiol 261:E457–E465PubMedGoogle Scholar
  21. 21.
    Stephens JM, Pekala PH (1991) Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. J Biol Chem 266:21839–21845PubMedGoogle Scholar
  22. 22.
    Mackay AG, Oliver JD, Rogers MP (1990) Regulation of lipoprotein lipase activity and mRNA content in rat epididymal adipose tissue in vitro by recombinant tumour necrosis factor. Biochem J 269:123–126PubMedGoogle Scholar
  23. 23.
    Hardardottir I, Doerrler W, Feingold KR, Grunfeld C (1992) Cytokines stimulate lipolysis and decrease lipoprotein lipase activity in cultured fat cells by a prostaglandin independent mechanism. Biochem Biophys Res Commun 186:237–243PubMedCrossRefGoogle Scholar
  24. 24.
    Adi S, Pollock AS, Shigenaga JK et al (1992) Role for monokines in the metabolic effects of endotoxin. Interferon-gamma restores responsiveness of C3H/HeJ mice in vivo. J Clin Invest 89:1603–1609PubMedGoogle Scholar
  25. 25.
    Beutler B, Cerami A (1986) Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature 320:584–588PubMedCrossRefGoogle Scholar
  26. 26.
    Jirillo E, Covelli V, Maffione AB et al (1994) Endotoxins, cytokines, and neuroimmune networks with special reference to HIV infection. Ann NY Acad Sci 741:174–184PubMedCrossRefGoogle Scholar
  27. 27.
    Renno T, Krakowski M, Piccirillo C et al (1995) TNF-alpha expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. Regulation by Thl cytokines. J Immunol 154:944–953Google Scholar
  28. 28.
    Tracey KJ, Lowry SF (1990) The role of cytokine mediators in septic shock. Adv Surg 23:21–56PubMedGoogle Scholar
  29. 29.
    Helfgott DC, Tatter SB, Santhanam U et al (1989) Multiple forms of IFN-beta 2/IL-6 in serum and body fluids during acute bacterial infection. J Immunol 142:948–953PubMedGoogle Scholar
  30. 30.
    Castell JV, Gomez-Lechon MJ, David M et al (1989) Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS Lett 242:237–239PubMedCrossRefGoogle Scholar
  31. 31.
    Garman RD, Jacobs KA, Clark SC, Raulet DH (1987) B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells. Proc Natl Acad Sci USA 84:7629–7633PubMedCrossRefGoogle Scholar
  32. 32.
    Stouthard JM, Romijn JA, Van der Poll T et al (1995) Endocrinologie and metabolic effects of interleukin-6 in humans. Am J Physiol 268:E813–E819PubMedGoogle Scholar
  33. 33.
    Papanicolaou DA, Petrides JS, Tsigos C et al (1996) Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines. Am J Physiol 271:E601–E605PubMedGoogle Scholar
  34. 34.
    Luedke CE, Cerami A (1990) Interferon-gamma overcomes glucocorticoid suppression of cachectin/tumor necrosis factor biosynthesis by murine macrophages. J Clin Invest 86:1234–1240PubMedGoogle Scholar
  35. 35.
    Nathan CF, Murray HW, Wiebe ME, Rubin BY (1983) Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med 158:670–689PubMedCrossRefGoogle Scholar
  36. 36.
    Matthys P, Dijkmans R, Proost P et al (1991) Severe cachexia in mice inoculated with interferongamma-producing tumor cells. Int J Cancer 49:77–82PubMedCrossRefGoogle Scholar
  37. 37.
    Mantovani G, Macciò A, Massa E, Madeddu C (2001) Managing cancer-related anorexia/cachexia. Drugs 61:499–514PubMedCrossRefGoogle Scholar
  38. 38.
    Freeman LM, Roubenoff R (1994) The nutrition implication of cardiac cachexia. Nutr Rev 52:340–347PubMedCrossRefGoogle Scholar
  39. 39.
    Morley JE, Baumgartner RN, Roubenoff R et al (2001) Sarcopenia. J Lab Clin Med 137:231–243PubMedCrossRefGoogle Scholar
  40. 40.
    Heimburger DC, Weinsier RL (1997) Handbook of clinical nutrition. Mosby, St LouisGoogle Scholar
  41. 41.
    Fearon KC, Barber MD, Falconer JS et al (1999) Pancreatic cancer as a model: inflammatory mediators, acute-phase response, and cancer cachexia. World J Surg 23:584–588PubMedCrossRefGoogle Scholar
  42. 42.
    Baumann H, Gauldie J (1994) The acute phase response. Immunol Today 15:74–80PubMedCrossRefGoogle Scholar
  43. 43.
    Slaviero KA, Read JA, Clarke SJ, Rivory LP (2003) Baseline nutritional assessment in advanced cancer patients receiving palliative chemotherapy. Nutr Cancer 46:148–157PubMedCrossRefGoogle Scholar
  44. 44.
    Lord GM, Matarese G, Howard JK et al (1998) Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394:897–901PubMedCrossRefGoogle Scholar
  45. 45.
    Palacio A, Lopez M, Perez-Bravo F et al (2002) Leptin levels are associated with immune response in malnourished infants. J Clin Endocrinol Metab 87:3040–3046PubMedCrossRefGoogle Scholar
  46. 46.
    Sanchez-Margalet V, Martin-Romero C, Santos-Alvarez J et al (2003) Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin Exp Immunol 133:11–19PubMedCrossRefGoogle Scholar
  47. 47.
    La Cava A, Alviggi C, Matarese G (2004) Unraveling the multiple roles of leptin in inflammation and autoimmunity. J Mol Med 82:4–11PubMedCrossRefGoogle Scholar
  48. 48.
    Field CJ (2000) Use of T cell function to determine the effect of physiologically active food components. Am J Clin Nutr 71:1720S–1725SPubMedGoogle Scholar
  49. 49.
    Bistrian BR, Blackburn GL, Sherman M et al (1975) Therapeutic index of nutritional depletion in hospitalized patients. Surg Gynecol Obstet 141:512–516PubMedGoogle Scholar
  50. 50.
    McMurray DN (1984) Cell-mediated immunity in nutritional deficiency. Prog Food Nutr Sci 8:193–228PubMedGoogle Scholar
  51. 51.
    Christou NV, Meakins JL, Gordon J et al (1995) The delayed hypersensitivity response and host resistance in surgical patients. 20 years later. Ann Surg 222:534–538PubMedCrossRefGoogle Scholar
  52. 52.
    Beisel WR (1995) Herman Award Lecture, 1995: infection-induced malnutrition—from cholera to cytokines. Am J Clin Nutr 62:813–819PubMedGoogle Scholar
  53. 53.
    Jolly CA, Jiang YH, Chapkin RS et al (1997) Dietary (n-3) polyunsaturated fatty acids suppress murine lymphoproliferation, interleukin-2 secretion, and the formation of diacylglycerol and ceramide. J Nutr 127:37–43PubMedGoogle Scholar
  54. 54.
    Docherty K, Clark AR (1994) Nutrient regulation of insulin gene expression. FASEB J 8:20–27PubMedGoogle Scholar
  55. 55.
    Robinson LE, Field CJ (1998) Dietary long chain (n-3) fatty acids facilitate immune cell activation in sedentary, but not exercise-trained rats. J Nutr 128:498–504PubMedGoogle Scholar
  56. 56.
    Wu GY, Field CJ, Marliss EB (1991) Elevated glutamine metabolism in splenocytes from spontaneously diabetic BB rats. Biochem J 274:40–54Google Scholar
  57. 57.
    Yaqoob P, Knapper JA, Webb DH et al (1998) Effect of olive oil on immune function in middle-aged men. Am J Clin Nutr 67:129–135PubMedGoogle Scholar
  58. 58.
    Calder PC, Yaqoob P, Harvey DJ et al (1994) Incorporation of fatty acids by concanavalin A-stimulated lymphocytes and the effect on fatty acid composition and membrane fluidity. Biochem J 300:509–518PubMedGoogle Scholar
  59. 59.
    Clandinin MT, Cheema S, Field CJ et al (1991) Dietary fat: exogenous determination of membrane structure and cell function. FASEB J 5:2761–2769PubMedGoogle Scholar
  60. 60.
    Peck MD (1994) Interactions of lipids with immune function II: experimental and clinical studies of lipids and immunity. J Nutr Biochem 5:514–520CrossRefGoogle Scholar
  61. 61.
    Meydani M, Meydani SN, Shapiro AC et al (1991) Influence of dietary fat, vitamin E, ethoxyquin and indomethacin on the synthesis of prostaglandin E2 in brain regions of mice. J Nutr 121:438–444PubMedGoogle Scholar
  62. 62.
    Yoshida AH, Keen CL, Ansari AA, Gershwin E (1999) Nutrition and the immune system. In: Schills ME, Olson JA, Shike M, Ross AC (eds) Modern nutrition in health and disease, 9th ed. Williams & Wilkins, Baltimora,pp 725–750Google Scholar
  63. 63.
    Ferguson A (1994) Immunological functions of the gut in relation to nutritional state and mode of delivery of nutrients. Gut 35:S10–S12PubMedCrossRefGoogle Scholar
  64. 64.
    Weiner HL, Friedman A, Miller A et al (1994) Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol 12:809–837PubMedCrossRefGoogle Scholar
  65. 65.
    Carver JD (1994) Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J Nutr 124:144S–148SPubMedGoogle Scholar
  66. 66.
    Van Buren CT, Kulkarni AD, Rudolph FB (1994) The role of nucleotides in adult nutrition. J Nutr 124:160S–164SPubMedGoogle Scholar
  67. 67.
    Newberne PM, Locniskar M (1991) Nutrition and immune status. In: Rowland I (ed) Nutrition, toxicity, and cancer. CRC Press, Boca RatonGoogle Scholar
  68. 68.
    Kramer TR, Johnson WT (1993) Copper and immunity. In: Cunningham-Rundles S (ed) Nutrient modulation of immune response. Marcel Dekker, New YorkGoogle Scholar
  69. 69.
    O’Dell BL (1993) Interleukin-2 production is altered by copper deficiency. Nutr Rev 51:307–309CrossRefGoogle Scholar
  70. 70.
    Kelley DS, Daudu PA, Taylor PC et al (1995) Effects of low-copper diets on human immune response. Am J Clin Nutr 62:412–416PubMedGoogle Scholar
  71. 71.
    Myrvik QN (1994) Immunology and nutrition. In: Shills ME, Olson JA, Shike M (eds) Modern nutrition in health and disease, 8th ed. Lea & Febiger, Philadelphia, pp 623–662Google Scholar
  72. 72.
    Whitley WD, Hancock WW, Kupiec-Weglinski JW et al (1993) Iron chelation suppresses mononuclear cell activation, modifies lymphocyte migration patterns, and prolongs rat cardiac allograft survival in rats. Transplantation 56:1182–1188PubMedCrossRefGoogle Scholar
  73. 73.
    Karlin KD (1993) Metalloenzymes, structural motifs, and inorganic models. Science 261:701–708PubMedCrossRefGoogle Scholar
  74. 74.
    Weiss G, Wachter H, Fuchs D (1995) Linkage of cellmediated immunity to iron metabolism. Immunol Today 16:495–500PubMedCrossRefGoogle Scholar
  75. 75.
    Redegeld F, Filippini A, Sitkovsky M (1991) Comparative studies of the cytotoxic T lymphocytemediated cytotoxicity and of extracellular ATP-induced cell lysis. Different requirements in extracellular Mg2+ and pH. J Immunol 147:3638–3645PubMedGoogle Scholar
  76. 76.
    Mantovani G, Macciò A, Madeddu C et al (2004) Selenium is effective in inducing lymphocyte progression through cell cycle in cancer patients: potential mechanisms for its activity. J Exp Ther Oncol 4: 69–78PubMedGoogle Scholar
  77. 77.
    Kuvibidila S, Yu L, Ode D et al (1993) The immune response in protein-energy malnutrition and single nutrient deficiencies. In: Klurfield DM (ed) Nutrition and immunology. Plenum Press, New York.pp 121–157Google Scholar
  78. 78.
    Taylor EW (1995) Selenium and cellular immunity. Evidence that selenoproteins may be encoded in the +1 reading frame overlapping the human CD4, CD8, and HLA-DR genes. Biol Trace Elem Res 49:85–95PubMedCrossRefGoogle Scholar
  79. 79.
    Vruwink KG, Keen CL, Gershwin ME et al (1993) The effect of experimental zinc deficiency on development of the immune system. In: Cunningham-Rundles S (ed) Nutrient modulation of the immune response. Marcel Dekker, New York, pp 263–279Google Scholar
  80. 80.
    Berg JM, Shi Y 1996 The galvanization of biology: a growing appreciation for the roles of zinc. Science 271:1081–1085PubMedCrossRefGoogle Scholar
  81. 81.
    Lorenson MY, Patel T, Liu JW, Walker AM (1996) Prolactin (PRL) is a zinc-binding protein. I. Zinc interactions with monomeric PRL and divalent cation protection of intragranular PRL cysteine thiols. Endocrinology 137:809–816PubMedCrossRefGoogle Scholar
  82. 82.
    Hadden JW (1995) The treatment of zinc deficiency is an immunotherapy. Int J Immunopharmacol 17:697–701PubMedCrossRefGoogle Scholar
  83. 83.
    Cook-Mills JM, Fraker PJ (1993) The role of metals in the production of toxic oxygen metabolites by mononuclear phagocytes. In: Cunningham-Rundles S (ed) Nutrient modulation of the immune response. Marcel Dekker, New York, pp 127–140Google Scholar
  84. 84.
    Blumberg JB (1994) Vitamins. In: Forse RA (ed) Diet, nutrition, and immunity. CRC Press, Boca Raton, p 237Google Scholar
  85. 85.
    Ross AC, Hammerling UG (1994) Retinoids and the immune system. In: Sporn MB, Roberts AB, Goodman DS (eds) The retinoids: biology, chemistry, and medicine, 2nd ed. Raven Press, New York, pp 521a–543aGoogle Scholar
  86. 86.
    Mawson AR, Onor GI (1991) Gout and vitamin A intoxication: is there a connection? Semin Arthritis Rheum 20:297–304PubMedCrossRefGoogle Scholar
  87. 87.
    Iwata M, Mukai M, Nakai Y, Iseki R (1992) Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes. J Immunol 149:3302–3308PubMedGoogle Scholar
  88. 88.
    Bates CJ (1995) Vitamin A. Lancet 345:31–35PubMedCrossRefGoogle Scholar
  89. 89.
    Muggli R (1993) Vitamin C and phagocytes. In: Cunningham-Rundles S (ed) Nutrient modulation of the immune response. Marcel Dekker, New YorkGoogle Scholar
  90. 90.
    Cunningham-Rundles WF, Berner Y, Cunningham-Rundles S (1993) Interaction of vitamin C in lymphocyte activation: current status and possible mechanism of action. In: Cunningham-Rundles S (ed) Nutrient modulation of the immune response. Marcel Dekker, New YorkGoogle Scholar
  91. 91.
    Meydani SN, Blumberg JB (1993) Vitamin E and the immune response. In: Cunningham-Rundles S (ed) Nutrient modulation of the immune response. Marcel Dekker, New YorkGoogle Scholar
  92. 92.
    Wang Y, Huang DS, Eskelson CD, Watson RR (1994) Long-term dietary vitamin E retards development of retrovirus-induced disregulation in cytokine production. Clin Immunol Immunopathol 72:70–75PubMedCrossRefGoogle Scholar
  93. 93.
    Taraszewski R, Jensen GL (1994) N-6 fatty acids. In: Forse RA (ed) Diet, nutrition, and immunity. CRC Press, Boca Raton, pp 165–177Google Scholar
  94. 94.
    Calder PC (1997) N-3 polyunsaturated fatty acids and cytokine production in health and disease. Ann NutrMetab 41:203–234Google Scholar
  95. 95.
    Gogos CA, Ginopoulos P, Salsa B et al (1998) Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial. Cancer 82:395–402PubMedCrossRefGoogle Scholar
  96. 96.
    Gogos CA, Kalfarentzos F (1995) Total parenteral nutrition and immune system activity: a review. Nutrition 11:339–344PubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • Clelia Madeddu
    • 1
  • Giovanni Mantovani
    • 1
  1. 1.Department of Medical OncologyUniversity of CagliariCagliariItaly

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