Abstract
From the previous chapter it should be clear that in most cases the before-after comparison in a single group of patients is an inadequate experimental design, as it fails to achieve comparisons free from bias. “Before” is not a good control for “after”, since the effects of many factors are mixed with the effect of the treatment, introducing all kinds of systematic errors. Generally, in this type of experimental design, bias has the effect of simulating or exaggerating the effect of the treatment.
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© 2007 Springer-Verlag Italia, Milano
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(2007). Experimental Design: the Randomized Blinded Study as an Instrument to Reduce Bias. In: Fundamentals of Clinical Research. Statistics for Biology and Health. Springer, Milano. https://doi.org/10.1007/978-88-470-0492-4_9
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DOI: https://doi.org/10.1007/978-88-470-0492-4_9
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0491-7
Online ISBN: 978-88-470-0492-4
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