Possible Causative or Contributing Role of Viruses

  • Fiorella Calabrese
  • Elisa Carturan
  • Gaetano Thiene
  • Jeffrey A. Towbin


Arrhthmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a primary heart muscle disease characterized by transmural fibrofatty replacement of the right ventricle and clinically by life-threatening ventricular arrhythmias in apparently healthy people [1]. The disease results in a high risk of sudden death, particularly in young people [2] and athletes [3]. Over the past several years, the genetic basis of this disease has been unraveled and shown to be a disease of the desmosome [4]. Mutations in desmoplakin, plakoglobin, plakophilin, desmoglein, and desmocollin have been identified, along with the desmosome modifying gene TGF-β3 [5, 6, 7, 8, 9, 10].


Right Ventricle Polymerase Chain Reac Ventricular Cardiomyopathy Arrhythmogenic Right Ventricular Dysplasia Endocardial Fibroelastosis 
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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Fiorella Calabrese
    • 1
  • Elisa Carturan
    • 1
  • Gaetano Thiene
    • 1
  • Jeffrey A. Towbin
    • 2
  1. 1.Department of Medical Diagnostic SciencesUniversity of PaduaItaly
  2. 2.Pediatric Cardiology, Texas Children’s HospitalBaylor College of MedicineHoustonUSA

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