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Arrhythmogenic RV Cardiomyopathy/Dysplasia pp 79–85Cite as

Possible Causative or Contributing Role of Viruses

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Abstract

Arrhthmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a primary heart muscle disease characterized by transmural fibrofatty replacement of the right ventricle and clinically by life-threatening ventricular arrhythmias in apparently healthy people [1]. The disease results in a high risk of sudden death, particularly in young people [2] and athletes [3]. Over the past several years, the genetic basis of this disease has been unraveled and shown to be a disease of the desmosome [4]. Mutations in desmoplakin, plakoglobin, plakophilin, desmoglein, and desmocollin have been identified, along with the desmosome modifying gene TGF-β3 [5–10].

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Author information

Authors and Affiliations

  1. Department of Medical Diagnostic Sciences, University of Padua, Italy

    Fiorella Calabrese MD, Elisa Carturan & Gaetano Thiene MD

  2. Pediatric Cardiology, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, USA

    Jeffrey A. Towbin MD

Authors
  1. Fiorella Calabrese MD
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  2. Elisa Carturan
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  3. Gaetano Thiene MD
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  4. Jeffrey A. Towbin MD
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Editor information

Editors and Affiliations

  1. Section of Cardiology, Department of Medicine, Sarver Heart Center, University of Arizona, Tucson, AZ, USA

    Frank I. Markus

  2. Department of Cardiological, Thoracic and Vascular Sciences, University of Padua, Italy

    Andrea Nava

  3. Department of Medical Diagnostic Sciences, University of Padua, Italy

    Gaetano Thiene

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© 2007 Springer-Verlag Italia

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Calabrese, F., Carturan, E., Thiene, G., Towbin, J.A. (2007). Possible Causative or Contributing Role of Viruses. In: Markus, F.I., Nava, A., Thiene, G. (eds) Arrhythmogenic RV Cardiomyopathy/Dysplasia. Springer, Milano. https://doi.org/10.1007/978-88-470-0490-0_10

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  • DOI: https://doi.org/10.1007/978-88-470-0490-0_10

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0489-4

  • Online ISBN: 978-88-470-0490-0

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