Skip to main content

Estratto

Sono circa 3.500.000 nel mondo occidentale i pazienti annualmente sottoposti a chemioterapia con composti la cui tossicità è dose-limitante per il sistema nervoso centrale (SNC) e per il periferico (SNP).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 19.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 27.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliografia

  1. Keime-Guibert F, Napolitano M, Delattre JY (1998) Neurological complications of radiotherapy and chemotherapy. J Neurol 245:695–708

    Article  PubMed  CAS  Google Scholar 

  2. Quasthoff S, Hartung HP (2002) Chemotherapy-induced peripheral neuropathy. J Neurol 249:9–17

    Article  PubMed  CAS  Google Scholar 

  3. Verstappen CC, Heimans JJ, Hoekman K, Postma TJ (2003) Neurotoxic complications of chemotherapy in patients with cancer: clinical signs and optimal management. Drugs 63:1549–1563

    Article  PubMed  CAS  Google Scholar 

  4. Sghirlanzoni A, Pareyson D, Lauria G (2005) Sensory neuron diseases. Lancet Neurol 4:349–361

    Article  PubMed  CAS  Google Scholar 

  5. Peltier AC, Russell JW (2002) Recent advances in drug-induced neuropathies. Curr Opin Neurol 15:633–638

    Article  PubMed  Google Scholar 

  6. Guthrie TH Jr, Gynther L (1985) Acute deafness. A complication of high-dose cisplatin. Arch Otolaryngol 111:344–345

    PubMed  Google Scholar 

  7. Isoardo G, Bergui M, Durelli L, Barbero P, Boccadoro M, Bertola A, Ciaramitaro P, Palumbo A, Bergamasco B, Cocito D (2004) Thalidomide neuropathy: clinical, electrophysiological and neuroradiological features. Acta Neurol Scand 109:188–193

    Article  PubMed  CAS  Google Scholar 

  8. Ito Y, Arahata Y, Goto Y, Hirayama M, Nagamutsu M, Yasuda T, Yanagi T, Sobue G (1998) Cispatin neurotoxicity presenting as reversible posterior leucoencephalopathy syndrome. AJNR Am J Neuroradiol 19:415–417

    PubMed  CAS  Google Scholar 

  9. Philip PA, Carmichael J, Harris AL (1991) Convulsions and transient cortical blindness after cisplatin. BMJ 302:416

    PubMed  CAS  Google Scholar 

  10. Rangi PS, Partridge WJ, Newlands ES, Waldman AD (2005) Posterior reversible encephalopathy syndrome: a possible late interaction between cytotoxic agents and general anaesthesia. Neuroradiology 47:586–590

    Article  PubMed  CAS  Google Scholar 

  11. Verschraegen C, Conrad CA, Hong WK (1995) Subacute encephalopathy toxicity of cisplatin. Lung Cancer 13:305–309

    Article  PubMed  CAS  Google Scholar 

  12. Cascinu S, Catalano V, Cordella L, Labianca R, Giordani P, Baldelli AM, Beretta GD, Ubiali E, Catalano G (2002) Neuroprotective effect of reduced glutathione on oxaliplatin-based chemotherapy in advanced colorectal cancer: a randomized, double-blind, placebo-controlled trial. J Clin Oncol 20:3478–3483

    Article  PubMed  CAS  Google Scholar 

  13. Caraceni A, Martini C, Spatti G et al (1997) Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy. Acta Neurologica Scandinavica 96:260–261

    Article  PubMed  CAS  Google Scholar 

  14. Pace A, Savarese A, Picardo M et al (2003) Neuroprotective effect of vitamin E supplementation in patients treated with cisplatin chemotherapy. J Clin Oncol 21:927–931

    Article  PubMed  CAS  Google Scholar 

  15. Argyriou AA, Polychronopoulos P, Iconomou G et al (2005) Paclitaxel plus carboplatin-induced peripheral neuropathy A prospective clinical and electrophysiological study in patients suffering from solid malignancies. J Neurol 252:1459–1464

    Article  PubMed  CAS  Google Scholar 

  16. Bargallò N, Burrel M, Berenguer J, Cofan F, Bunesch L, Mercader M (2000) Cortical laminar necrosis caused by immunosuppressive therapy and chemotherapy. AJNR Am J Neuroradiol 21:479–484

    PubMed  Google Scholar 

  17. Freilich RJ, Balmaceda C, Seidman AD, Rubin M, DeAngelis LM (1996) Motor neuropathy due to docetaxel and paclitaxel. Neurology 47:115–118

    PubMed  CAS  Google Scholar 

  18. Mita C, Chatelut E, Bekradda M, Soulie P, Canal P, Misset JL, Cvitkovic E, Bugat R (2003) Phase I and pharmacological study of an oxaliplatin and carboplatin combination in advanced malignancies. Ann Oncol 14:1776–1782

    Article  PubMed  CAS  Google Scholar 

  19. Ziske CG, Schottker B, Gorschluter M, Mey U, Kleinschmidt R, Schlegel U, Sauerbrucher T, Schmidt-Wolf IGH (2002) Acute transient encephalopathy after paclitaxel infusion: report of three cases. Ann Oncol 13:629–631

    Article  PubMed  CAS  Google Scholar 

  20. Nieto Y, Cagnoni PJ, Bearman SI, Shpall EJ, Matthes S, DeBoom T, Baron A, Jones RB (1999) Acute encephalopathy: a new toxicity associated with high-dose paclitaxel. Clin Cancer Res 5:501–506

    PubMed  CAS  Google Scholar 

  21. Plotkin SR, Wen PY (2003) Neurologic complications of cancer therapy. Neurol Clin 21:279–318

    Article  PubMed  Google Scholar 

  22. Scaioli V, Caraceni A, Martini C, Curzi S, Capri G, Luca G (2005) Electrophysiological evaluation of visual pathways in paclitaxel-treated patients. J Neurooncol 25:1–9

    Google Scholar 

  23. van Laarhoven HW, Verstappen CC, Beex LV, Kappelle AC, Punt CJ (2003) 5-FU-induced peripheral neuropathy: a rare complication of a well-known drug. Anticancer Res 23:647–648

    PubMed  Google Scholar 

  24. Heier MS, Fossa SD (1986) Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5’-dFUrd). Acta Neurol Scand 73:449–457

    Article  PubMed  CAS  Google Scholar 

  25. Rubnitz JE, Relling MV, Harrison PL, Sandlund JT, Ribeiro RC, Rivera GK, Thompson SJ, Evans WE, Pui CH (1998) Transient encephalopathy following high-dose methotrexate treatment in childhood acute lymphoblastic leukemia. Leukemia 12:1176–1181

    Article  PubMed  CAS  Google Scholar 

  26. Rollins N, Winick N, Bash R, Booth T (2004) Acute methotrexate neurotoxicity: findings on diffusion-weighted imaging and correlation with clinical outcome. AJNR Am J Neuroradiol 25:1688–1695

    PubMed  Google Scholar 

  27. Fisher JM, Khademian ZP, Simon EM, Zimmerman RA, Bilaniuk LT (2005) Diffusion-weighted MR imaging of the early methotrexate-related neurotoxicity in children. AJNR Am J Neuroradiol 26:1686–1689

    PubMed  Google Scholar 

  28. Gagliano RG, Costanzi JJ (1976) Paraplegia following intrathecal methotrexate: report of a case and review of the literature. Cancer 37:1663–1668

    Article  PubMed  CAS  Google Scholar 

  29. Packer RJ, Sposto R, Atkins TE, Sutton LN, Bruce DA, Siegel KR, Rorke LB, Littman PA, Schut L (1987) Quality of life in children with primitive neuroectodermal tumors (medulloblastoma) of the posterior fossa. Pediatr Neurosci 13:169–175

    PubMed  CAS  Google Scholar 

  30. Cho SG, Moon H, Lee JH, Lee SY, Kim CC, Lee KS (1999) Behenoyl cytarabine-associated reversible encephalopathy in a patient with acute myelogenenous leukemia. J Korean Med Sci 14:89–92

    PubMed  CAS  Google Scholar 

  31. Vogel H, Horoupian DS (1993) Filamentous degeneration of neurons. A possible feature of cytosine arabinoside neurotoxicity. Cancer 71:1303–1308

    Article  PubMed  CAS  Google Scholar 

  32. Rieger C, Fiegl M, Tischer J, Ostermann H, Schiel X (2004) Anticancer Drugs 15:347–350

    Article  PubMed  CAS  Google Scholar 

  33. Wengs WJ, Talwar D, Bernard J (1993) Ifosfamide-induced nonconvulsive status epilepticus. Arch Neurol 50:1104–1105

    PubMed  CAS  Google Scholar 

  34. Meyer T, Ludolph AC, Munch C (2002) Ifosfamide encephalopathy presenting with asterixis. J Neurol Sci 199:85–88

    Article  PubMed  Google Scholar 

  35. Pelgrims J, De Vos F, Van den Brande J, Schrijvers D, Prove A, Vermorken JB (2000) Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature. Br J Cancer 82:291–294

    Article  PubMed  CAS  Google Scholar 

  36. Rosenblum MK, Delattre JY, Walker RW, Shapiro WR (1989) Fatal necrotizing encephalopathy complicating treatment of malignant gliomas with intra-arterial BCNU and irradiation: a pathological study. J Neurooncol 7:269–281

    Article  PubMed  CAS  Google Scholar 

  37. Omuro AMP, De Angelis LM, Yahalom J, Abrey LE (2005) Chemotherapy for primary CNS lymphoma: an intent-to-treat analysis with complete follow-up. Neurology 64:69–74

    Article  PubMed  CAS  Google Scholar 

  38. Adkins JC, Peters DH, Markham A (1997) Fludarabine An update of its pharmacology and use in the treatment of haematological malignancies. Drugs 53:1005–1037

    PubMed  CAS  Google Scholar 

  39. Cheson BD, Vena DA, Foss FM (1994) Neurotoxicity of purine analogs: a review. J Clin oncol 12:2216–2228

    PubMed  CAS  Google Scholar 

  40. Athale UH, Chan AKC (2003) Thrombosis in children with acute lymphoblastic leukemia Part II. Pathogenesis of thrombosis in children with acute lymphoblastic leukemia: effects of the disease and therapy. Thromb Res 111:199–212

    Article  PubMed  CAS  Google Scholar 

  41. Athale UH, Chan AKC (2003) Thrombosis in children with acute lymphoblastic leukemia Part I. Epidemiology of thrombosis in children with acute lymphoblastic leukemia. Thromb Res 111:125–131

    Article  PubMed  CAS  Google Scholar 

  42. Dietemann JL, Botelho C, Nogueira T, Vargas MI, Audibert C, Abu Eid M, Bogorin A, Bernardo R, Jacques C, Kremer S, Zollner G (2004) Imaging in acute toxic encephalopathy. J Neuroradiol 31:313–326

    Article  PubMed  Google Scholar 

  43. Serkova NJ, Christians U, Benet LZ (2004) Biochemical mechanisms of cyclosporine neurotoxicity. Mol Interv 4:97–107

    Article  PubMed  CAS  Google Scholar 

  44. Casey SO, Ricardo C, Sampaio C, Truwit EM, Truwit CL (2000) Posterior reversible encephalopathy syndrome: utility of Fluid-attenuated Inversion Recovery MR imaging in the detection of cortical and subcortical lesions. AJNR Am J Neuroradiol 21:1199–1206

    PubMed  CAS  Google Scholar 

  45. Lamy C, Mas JL (2001) Reversible posterior leukoencephalopathy. A new syndrome or a new name for an old syndrome? Presse Med 30:915–920

    PubMed  CAS  Google Scholar 

  46. Gultekin SH, Rosenfeld MR, Voltz R, Eichen J, Posner JB (2000) Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients. Brain 123:1481–1494

    Article  PubMed  Google Scholar 

  47. Mandrioli J, Cortelli P (2004) Patologie del sistema nervoso vegetativo. In: Sghirlanzoni A, Lauria G, Nardocci N, Pareyson D (eds) Terapia delle malattie neurologiche. Edi-Ermes, Milano, pp 309–328

    Google Scholar 

  48. Lauria G, Pareyson D, Grisoli M, Sghirlanzoni A (2000) Clinical and magnetic resonance imaging findings in chronic sensory ganglionopathies. Ann Neurol 47:104–109

    Article  PubMed  CAS  Google Scholar 

  49. Uhm JH, Yung WK (1999) Neurologic complications of cancer therapy. Curr Treat Options Neurol 1:428–437

    PubMed  Google Scholar 

  50. Cavaletti G, Zanna C (2002) Current status and future prospects for the treatment of chemotherapy-induced peripheral neurotoxicity. Eur J Cancer 38:1832–1837

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Italia, Milano

About this chapter

Cite this chapter

Erbetta, A., Lauria, G., Sghirlanzoni, A. (2006). Complicazioni della chemioterapia. In: Le complicazioni neurologiche in oncologia. Springer, Milano. https://doi.org/10.1007/978-88-470-0440-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-0440-5_12

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0439-9

  • Online ISBN: 978-88-470-0440-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics