Proton MR Spectroscopy

  • N. De Stefano
Part of the Topics in Neuroscience book series (TOPNEURO)


In the last few years, there has been an increased appreciation of the apparently primary role of neuronal and axonal injury in the pathogenesis of multiple sclerosis (MS) [1, 2]. This has been driven to a significant degree by the results of proton magnetic resonance (MR) spectroscopy (1H-MRS) studies, which have emphasized that substantial neuroaxonal damage occurs inside the demyelinating lesions as well as in the normal-appearing white matter (NAWM) and gray matter (GM) of the brain of patients with MS [2, 3]. All this has been confirmed pathologically [1, 4, 5] and has led to a reconsideration of the role of axonal damage in MS [6].


Multiple Sclerosis Axonal Injury Multiple Sclerosis Lesion Axonal Damage Magnetic Resonance Spectroscopy Study 
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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • N. De Stefano
    • 1
  1. 1.Department of Neurological and Behavioral SciencesUniversity of SienaSienaItaly

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