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T1 Black Holes and Gray Matter Damage

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Neurodegeneration in Multiple Sclerosis

Part of the book series: Topics in Neuroscience ((TOPNEURO))

Abstract

Magnetic resonance imaging (MRI) has become important in the early diagnosis and monitoring of various neurologic disorders including multiple sclerosis (MS). MRI has emerged as a key supportive therapeutic outcome measure in MS-related clinical trials. The limitations of conventional MRI surrogates have driven researchers to develop better biomarkers, including those capturing destructive aspects of the disease. In this chapter, we discuss the most recent data highlighting the role of hypointense lesions on T1-weighted images (black holes; BH) and gray matter (GM) damage in the MRI assessment of MS. We focus on the most relevant pathologic, MRI, and clinical correlation studies addressing BH and GM injury.

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Author information

Authors and Affiliations

  1. Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA

    M. Neema, V.S.R. Dandamudi, A. Arora, J. Stankiewicz & R. Bakshi

Authors
  1. M. Neema
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  2. V.S.R. Dandamudi
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  3. A. Arora
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  4. J. Stankiewicz
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  5. R. Bakshi
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Editor information

Editors and Affiliations

  1. Neuroimaging Research Unit Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy

    Massimo Filippi  & Marco Rovaris  & 

  2. Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy

    Giancarlo Comi

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© 2007 Springer-Verlag Italia

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Neema, M., Dandamudi, V., Arora, A., Stankiewicz, J., Bakshi, R. (2007). T1 Black Holes and Gray Matter Damage. In: Filippi, M., Rovaris, M., Comi, G. (eds) Neurodegeneration in Multiple Sclerosis. Topics in Neuroscience. Springer, Milano. https://doi.org/10.1007/978-88-470-0391-0_4

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  • DOI: https://doi.org/10.1007/978-88-470-0391-0_4

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0390-3

  • Online ISBN: 978-88-470-0391-0

  • eBook Packages: MedicineMedicine (R0)

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