Neuropathological Advances in Multiple Sclerosis

  • E. Capello
  • A. Uccelli
  • M. Pizzorno
  • G.L. Mancardi
Part of the Topics in Neuroscience book series (TOPNEURO)


The neuropathology of multiple sclerosis (MS) has been thoroughly and carefully described since the pioneer studies on the disease [1]. It was already clear in the last years of the 1800s that MS is an inflammatory disease of the central nervous system (CNS) with scattered areas of demyelination and relative sparing of axons. The astroglial and microglial reactions, the possible loss of neurons, the axonal injury, and the capacity of the CNS to partly remyelinate the damaged areas were all widely known and described.


Multiple Sclerosis Multiple Sclerosis Patient Multiple Sclerosis Lesion Axonal Damage Acute Disseminate Encephalomyelitis 
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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • E. Capello
    • 1
  • A. Uccelli
    • 1
  • M. Pizzorno
    • 1
  • G.L. Mancardi
    • 1
  1. 1.Department of NeuroscienceOphtalmology and Genetics University of GenoaItaly

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