The Contribution of Reactive Oxygen Species in Sarcopenia and Muscle Aging

  • Stefania Fulle
  • Giorgio Fanò


In recent years, age-related diseases and disabilities have become of major interest and importance for health. This holds particularly for the Western community, where the remarkable improvement of medical health, standard of living, and hygiene have reduced the main causes of death. Despite numerous theories and intensive research, the principal molecular mechanisms underlying the process of aging are still unknown. Most, if not all, attempts to prevent or stop the onset of typical degenerative diseases associated with aging have so far been futile. Solutions to the major problems of dealing with age-related diseases can only come from a systematic and thorough molecular analysis of the aging process and a detailed understanding of its causes.


Skeletal Muscle Satellite Cell Chronic Fatigue Syndrome Skeletal Muscle Fiber Muscle Aging 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Harman D (1956) Aging: A theory based on free radical and radiation chemistry. J Gerontol 2:298–300Google Scholar
  2. 2.
    Harman D (1972) The biologic clock: The mitochondria? J Am Geriatr Soc 20:145–147PubMedGoogle Scholar
  3. 3.
    Lee HC, Wei YH (1997) Role of mitochondria in human aging. J Biomed Sci 4:319–326PubMedCrossRefGoogle Scholar
  4. 4.
    Frontera WR, Hughes VA, Fielding RA et al (2000) Aging of skeletal muscle: A 12-year longitudinal study. J Appl Physiol 88:1321–1326PubMedGoogle Scholar
  5. 5.
    Janssen I, Shepard DS, Katzmarzyk PT et al (2004) The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc 52:80–85PubMedCrossRefGoogle Scholar
  6. 6.
    Rantanen T, Guralnik JM, Foley D et al (1999) Midlife hand grip strength as a predictor of old age disability. JAMA 281:558–560PubMedCrossRefGoogle Scholar
  7. 7.
    Di Tano G, Fulle S, Pietrangelo T et al (2005) Sarcopenia: Characteristics, genesis, remedies. Sport Sci Health 1:69–74CrossRefGoogle Scholar
  8. 8.
    Eu JP, Sun J, Xu L et al (2000) The skeletal muscle calcium release channel: Coupled O2 sensor and NO signaling functions. Cell 102:499–509PubMedCrossRefGoogle Scholar
  9. 9.
    Fulle S, Protasi F, Di Tano G et al (2004) The contribution of reactive oxygen species to sarcopenia and muscle aging. Exp Gerontol 39:17–24PubMedCrossRefGoogle Scholar
  10. 10.
    Mecocci P, Fanò G, Fulle S et al (1999) Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Rad Biol Med 26:303–308PubMedCrossRefGoogle Scholar
  11. 11.
    Fanò G, Mecocci P, Vecchiet J et al (2001) Age and sex influence on oxidative damage and functional status in human skeletal muscle. J Muscle Res Cell Motil 22:345–351PubMedCrossRefGoogle Scholar
  12. 12.
    Sun J, Xin C, Eu, JP et al (2001) Cysteine-3635 is responsible for skeletal muscle ryanodine receptor modulation by NO. Proc Natl Acad Sci U S A 98:11158–11162PubMedCrossRefGoogle Scholar
  13. 13.
    Yin D, Kuczera K, Squier TC (2000) The sensitivity of carboxyl-terminal methionines in calmodulin isoforms to oxidation by H(2)O(2) modulates the ability to activate the plasma membrane Ca-ATPase. Chem. Res. Toxicol 13:103–110PubMedCrossRefGoogle Scholar
  14. 14.
    Chatterjee SN, Agarwal S (1988) Liposomes as membrane model for study of lipid peroxidation. Free Rad Biol Med 4:51–72PubMedCrossRefGoogle Scholar
  15. 15.
    Belia S, Pietrangelo T, Fulle S et al (1998) Sodium nitroprusside, a NO donor, modifies Ca2+ transport and mechanical properties in frog skeletal muscle. J Muscle Cell Motil 19:865–876CrossRefGoogle Scholar
  16. 16.
    Fulle S, Mecocci P, Fano G et al (2000) Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome. Free Radic Biol Med 29:1252–1259PubMedCrossRefGoogle Scholar
  17. 17.
    Mauro A (1961) Satellite cell of skeletal muscle fibers. J Biophys Biochem Cytol 9:493–498PubMedCrossRefGoogle Scholar
  18. 18.
    Zammit PS, Heslop L, Hudon V et al (2002) Kinetics of myoblast proliferation show that resident satellite cells are competent to fully regenerate skeletal muscle fibers. Exp Cell Res 281:39–49PubMedCrossRefGoogle Scholar
  19. 19.
    Fulle S, Di Donna S, Puglielli C et al (2005) Age-dependent imbalance of the antioxidative system in human satellite cells. Exp Gerontol 40:189–197PubMedCrossRefGoogle Scholar
  20. 20.
    Squier TC (2001) Oxidative stress and protein aggregation during biological aging. Exp Gerontol 36:15339–15350CrossRefGoogle Scholar
  21. 21.
    Ji LL (2001) Exercise at old age: does it increase or alleviate oxidative stress? Ann N Y Acad Sci 928:236–247PubMedCrossRefGoogle Scholar
  22. 22.
    Goldspink DF (2005) Ageing and activity: Their effects on the functional reserve capacities of the heart and vascular smooth and skeletal muscles. Ergonomics 48:1334–1351PubMedCrossRefGoogle Scholar
  23. 23.
    LaStayo PC, Ewy GA, Pierotti DD et al (2003) The positive effects of negative work: Increased muscle strength and decreased fall risk in a frail elderly population. J Gerontol A Biol Sci Med Sci 58:M419–M424Google Scholar
  24. 24.
    Hood DA (2001) Invited review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle. J Appl Physiol 90:1137–1157PubMedGoogle Scholar
  25. 25.
    Ojuka EO, Jones TE, Han DH et al (2003) Raising Ca2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle. FASEB J 17:675–681PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2007

Authors and Affiliations

  • Stefania Fulle
    • 1
  • Giorgio Fanò
    • 1
  1. 1.Center for Research on Ageing Interuniversity Institute of Myology Department Basic and Applied Medical SciencesUniversity “G. d’Annunzio”ChietiItaly

Personalised recommendations