Simultaneous Vascularised Bone Marrow Transplantation to Promote Acceptance of Limb Allografts
Rejection is prevented in clinical hand transplantation using immunosuppressive drugs. However, as these are non-life-saving transplants, it would be ideal to achieve a level of chimerism and/or tolerance sufficient to withdraw the antirejection drugs without compromising functional recovery and sensibility return. One perceived means to obtaining improved survival of transplanted tissues is administration of bone marrow (BM) cells, which has been used in both clinical practice and experimental investigation [1, 2]. There are several approaches to using these cells. One is to use donor bone marrow cells in conjunction with conventional or modified immunosuppression to promote survival. This has been used in the clinic where it has met with limited success and in experimental transplantation where the outcome has generally been improved.
KeywordsBone Marrow Cell Donor Cell Transplant Proc Brown Norway Donor Chimerism
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