Simultaneous Vascularised Bone Marrow Transplantation to Promote Acceptance of Limb Allografts

  • Marco Lanzetta
  • Alexander Kubitskiy
  • G. Alex Bishop
  • Jian Li
  • Geoffrey W. McCaughan


Rejection is prevented in clinical hand transplantation using immunosuppressive drugs. However, as these are non-life-saving transplants, it would be ideal to achieve a level of chimerism and/or tolerance sufficient to withdraw the antirejection drugs without compromising functional recovery and sensibility return. One perceived means to obtaining improved survival of transplanted tissues is administration of bone marrow (BM) cells, which has been used in both clinical practice and experimental investigation [1, 2]. There are several approaches to using these cells. One is to use donor bone marrow cells in conjunction with conventional or modified immunosuppression to promote survival. This has been used in the clinic where it has met with limited success and in experimental transplantation where the outcome has generally been improved.


Bone Marrow Cell Donor Cell Transplant Proc Brown Norway Donor Chimerism 


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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Marco Lanzetta
    • 1
    • 2
    • 3
    • 4
    • 5
  • Alexander Kubitskiy
    • 6
    • 7
  • G. Alex Bishop
    • 8
  • Jian Li
    • 7
  • Geoffrey W. McCaughan
    • 7
  1. 1.Italian Institute of Hand SurgeryMonza, MilanItaly
  2. 2.Hand Surgery and Reconstructive Microsurgery UnitSan Gerardo HospitalMonza, MilanItaly
  3. 3.University of Milan-BicoccaMilanItaly
  4. 4.University of CanberraAustralia
  5. 5.International Hand and CompositeTissue Allograft SocietyAustralia
  6. 6.Microsearch Foundation of AustraliaSydneyAustralia
  7. 7.AW Morrow Laboratory and Collaborative Transplantation GroupSydney UniversitySydneyAustralia
  8. 8.Collaborative Transplant LaboratorySydney UniversitySydneyAustralia

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