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Mechanisms Involved in the Induction of Tolerance in Allogeneic Hand Transplantation: A Proposal

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Hand Transplantation

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Abstract

The first human unilateral hand allotransplantation was performed in Lyon, in September 1998, followed by other cases all over the world. The technical feasibility of this procedure has thus been demonstrated. Whereas antigenicity of the skin was considered as the major obstacle to human composite tissue allotransplantation, clinical outcomes have demonstrated that hand allotransplantation seems to be well tolerated without drastic immunosuppressive drugs. This chapter briefly describes current advances in the field of tolerance to organ transplantation and elaborates suggestions for the reasons why hand transplantations are likely to be immunologically well tolerated by the host.

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Author information

Authors and Affiliations

  1. Mixed Unit of Immunogenomics, BioMerieux/HCL and Unit of Transplantation Surgery Department of Dermatology, Édouard Herriot Hospital, Lyon, France

    Assia Eljaafari

  2. Department of Transplantation, Édouard Herriot Hospital, Lyon, France

    Palmina Petruzzo, Xavier Martin & Jean-Michel Dubernard

  3. Department of Surgery, University of Cagliari, Italy

    Palmina Petruzzo

Authors
  1. Assia Eljaafari
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  2. Palmina Petruzzo
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  3. Xavier Martin
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  4. Jean-Michel Dubernard
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Editor information

Editors and Affiliations

  1. Italian Institute of Hand Surgery, Monza,Milan, Italy

    Marco Lanzetta (Director, Adjunct Professor and President) (Director, Adjunct Professor and President)

  2. University of Canberra, Australia

    Marco Lanzetta (Director, Adjunct Professor and President) (Director, Adjunct Professor and President)

  3. International Hand and Composite, Tissue Allograft Society, Australia

    Marco Lanzetta (Director, Adjunct Professor and President) (Director, Adjunct Professor and President)

  4. Department of Transplantation, Édouard Herriot Hospital, Lyon, France

    Jean-Michel Dubernard  & Palmina Petruzzo  & 

  5. Department of Surgery, University of Cagliari, Italy

    Palmina Petruzzo

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© 2007 Springer-Verlag Italia

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Eljaafari, A., Petruzzo, P., Martin, X., Dubernard, JM. (2007). Mechanisms Involved in the Induction of Tolerance in Allogeneic Hand Transplantation: A Proposal. In: Lanzetta, M., Dubernard, JM., Petruzzo, P. (eds) Hand Transplantation. Springer, Milano. https://doi.org/10.1007/978-88-470-0374-3_56

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  • DOI: https://doi.org/10.1007/978-88-470-0374-3_56

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0373-6

  • Online ISBN: 978-88-470-0374-3

  • eBook Packages: MedicineMedicine (R0)

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