Mechanisms Involved in the Induction of Tolerance in Allogeneic Hand Transplantation: A Proposal

  • Assia Eljaafari
  • Palmina Petruzzo
  • Xavier Martin
  • Jean-Michel Dubernard


The first human unilateral hand allotransplantation was performed in Lyon, in September 1998, followed by other cases all over the world. The technical feasibility of this procedure has thus been demonstrated. Whereas antigenicity of the skin was considered as the major obstacle to human composite tissue allotransplantation, clinical outcomes have demonstrated that hand allotransplantation seems to be well tolerated without drastic immunosuppressive drugs. This chapter briefly describes current advances in the field of tolerance to organ transplantation and elaborates suggestions for the reasons why hand transplantations are likely to be immunologically well tolerated by the host.


Human Leukocyte Antigen Human Mesenchymal Stem Cell Tolerance Induction Peripheral Tolerance Allograft Tolerance 


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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Assia Eljaafari
    • 1
  • Palmina Petruzzo
    • 2
    • 3
  • Xavier Martin
    • 2
  • Jean-Michel Dubernard
    • 2
  1. 1.Mixed Unit of Immunogenomics, BioMerieux/HCL and Unit of Transplantation Surgery Department of DermatologyÉdouard Herriot HospitalLyonFrance
  2. 2.Department of TransplantationÉdouard Herriot HospitalLyonFrance
  3. 3.Department of SurgeryUniversity of CagliariItaly

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