Abstract
This chapter presents current issues for possible limb transplantation in newborns and indicates directions, which will be likely to produce some answers on different feasibility aspects. Even if total hand transplantation (HT) will never be used in congenital individuals, current research advancements may allow composite tissue allotransplantation (CTA) to be an adequate tool for managing many currently “incurable” malformations presenting with different missing anatomical parts. There are numerous cases of congenital limb deformities (CLD) in which failure of formation or development has no surgical answer because we are unable to restore or properly replace the missing parts. “Confusion arises also from the circumstance that these anomalies are never exactly alike” [1].
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References
Kelikian H (1974) Congenital deformities of the hand and forearm. WB Saunders, Philadelphia
Lundborg G (2000) Tomorrow’s artificial hand. Scand J Plast Reconstr Surg Hand Surg 34:97–100
Lorenz HP, Hedrick MH, Chang J et al (2000) The impact of biomolecular medicine and tissue engineering on plastic surgery in the 21st century. Plast Reconstr Surg 105:2467–2481
Eppley BL (2001) Paediatric plastic surgery revisited. Clin Plast Surg 28:731–444
Breuer C, Anthony T, Fong P (2004) Potential tissueengineering applications for neonatal surgery. Semin Perinatol 28:164–173
Chong AK, Chang J (2006) Tissue engineering for the hand surgeon: a clinical perspective. J Hand Surg [Am] 31:349–358
Dubernard JM, Owen E, Herzberg G et al (1999) Première transplantation de main chez l’homme. Résultats précoces. Chir 124:358–365
Dubernard JM, Owen E, Herzberg G et al (1999) Human hand allograft: report on first 6 months. Lancet 353:1315–1320
Petit F, Paraskevas A, Garrido I, Lantieri L (2005) La transplantation est-elle l’avenir de la microchirurgie? Ann Chir Plast Esth 50:76–79
Hettiaratchy S, Randolph MA, Petit F et al (2004) Composite tissue allotransplantation — a new era in plastic surgery? Br J Plast Surg 57:381–391
Petit F (2002) Allotransplantation de tissus composites et chirurgie réparatrice. Les premières applications cliniques. Maîtrise Orthopédique 111. www.maitrise-orthop.com
Swanson AB (1976) A classification for congenital limb malformations. J Hand Surg [Am] 1:8–22
James MA, Bednar M (2005) Deformities of the wrist and forearm: transverse failure of formation. In: Green DP et al (eds) Green’s operative hand surgery, 5th Edn, Vol 2. Elsevier Churchill Livingstone, Philadelphia, pp 1489–1491
www.handregistry.com/default_noflash/English/Info_for_Patients/Causes_of_Hand_Loss/causes_of_hand_loss.html
Foucher G (1999) Commentary: prospects for hand transplantation. Lancet 353:1286–1287
Lundborg G (1999) Hand transplantation. Scand J Plast Reconstr Surg 33:369–371
Manske PR (2001) Hand transplantation. J Hand Surg [Am] 26:193–195
Jones NF (2002) Concerns about human hand transplantation in the 21st century. J Hand Surg [Am] 27:771–787
Lees VC, McCabe SJ (2002) The rationale for hand transplantation. Transplantation 74:749–753
Gazarian A, Gonnaud F, Queney-Rouyer AP (2000) Trois regards, une consultation. Prise en charge interdisciplinaire des anomalies congénitales de la main. Le Pédia 200:6–11
Mertes K (2006) Personal communication
Peillon B (2006) Personal communication
McCarroll HR (2000) Congenital anomalies: a 25-year overview. J Hand Surg [Am] 25:1007–1037
McGuirk CK, Westgate M-N, Holmes LB (2001) Limb deficiencies in newborn infants. Pediatrics 108:E64
Apkon S (2004) Pediatric limb deficiencies. PM&R Update 8:1–4
Choumon B, Ritz A, Corbet E et al (2002) Agénésie unilatérale d’avant-bras et prothétisation: mise en regard des représentations de parents et de professionnels. Rev Chir Orthop 88:117–124
Czeizel A, Kodaj I, Lenz W (1994) Smoking during pregnancy and congenital limb deficiency. Br Med J 308:1473–1476
Froster UG, Baird PA (1992) Congenital defects of the limbs and alcohol exposure in pregnancy: data from a population based study. Am J Med Genet 44:782–785
Holmes LB (2002) Teratogen-induced limb defects. Am J Med Genet 112:297–303
Hooper G (2000) Functional prostheses. In: Gupta et al (eds) The growing hand. Mosby, St. Louis, pp 1075–1078
Pillet J (2000) Esthetic prostheses. In: Gupta et al (eds) The growing hand. Mosby, St. Louis, pp 1079–1090
Scotland TR, Galway HR (1983) A long-term review of children with congenital and acquired upper limb deficiency. J Bone Joint Surg Br 65:346–349
Jain S (1996) Rehabilitation in limb deficiency: II. The pediatric amputee. Arch Phys Med Rehabil 77:S9–S13
Mark TJ, Phillip EW (1992) Congenital anomalies of hand. In: Crenshaw AH (ed) Campbell’s operative orthopaedics. Mosby-Year Book, St. Louis 5:3353–3425
Muzaffar AR (2003) Hand V: fractures and dislocations; the wrist; congenital anomalies. Selected Readings in Plastic Surgery 9:1–56
Kozin SH (2003) Upper-extremity congenital anomalies. J Bone Joint Surg Am 85:1564–1575
Schwabe GC, Mundlos S (2004) Genetics of congenital anomalies. Handchir Mikrochir Plast Chir 36:85–97
Daluiski A, Yi SE, Lyons KM (2001) The molecular control of upper extremity development: implications for congenital hand anomalies. J Hand Surg [Am] 26:8–22
Britto J, Chan J, Evans R et al (2001) Differential expression of FGF receptors in human digital development suggests common pathogenesis in complex acrosyndactyly & craniosynostosis. Plast Reconstr Surg 107:1331–1338
Tonkin MA (2004) An introduction to congenital hand anomalies. Handchir Mikrochir Plast Chir 36:75–84
Cohn MJ, Bright PE (1999) Molecular control of vertebrate limb development, evolution and congenital malformations. Cell Tissue Res 296:3–17
Choumon B, Fischer S, Gréco J, Ritz A, Bérard C (2006) Parcours devie d’adultes présentant une agénésie unilatérale d’avant-bras: enjeux et incidence du recours à la prothèse sur l’image de soi et les relations sociales. Rev Chir Orthop 92:27–32
Datta D, Selvarajah K, Davey N (2004) Functional outcome of patients with proximal upper limb deficiency — acquired and congenital. Clin Rehab 18:172–177
Dubert T, Voche P, Dumontier C, Dinh A (2001) [The DASH questionnaire. French translation of a transcultural adaptation]. Chir Main 20:294–302
Nicholas R (2005) Ethical considerations in allograft tissue transplantation: a surgeon’s perspective. Clin Orthop Relat Res 435:11–16
Baumeister S, Kleist C, Dohler B et al (2004) Risks of allogeneic hand transplantation. Microsurgery 20:98–103
Brenner MJ, Tung TH, Jensen JN, Mackinnon SE (2002) The spectrum of complications of immunosuppression: is the time right for hand transplantation? J Bone Joint Surg Am 84:1861–1870
Breidenbach WC, Tobin GR, Gorantla VS et al (2002) A position statement in support of hand transplantation. J Hand Surg [Am] 27:760–770
Auchincloss H Jr (2001) In search of the elusive Holy Grail: the mechanisms and prospects for achieving clinical transplantation tolerance. Am J Transplant 1:6–12
Morrow WR, Chinnock RE (2000) Survival after heart transplantation. In: Tejani et al (eds) Pediatric solid organ transplantation. Munksgaard, Copenhagen, pp 417–426
West LJ (2002) Developmental aspects of immunomodulation: exploiting the immature immune system for organ transplantation. Transpl Immunol 9:149–153
West LJ (2002) Defining critical windows in the development of the human immune system. Hum Exp Toxicol 21:499–505
Holan V (1990) Absolute specificity of neonatally induced transplantation tolerance. Transplantation 50:1072–1074
Butler PE, Lee WP, van de Water AP, Randolph MA (2000) Neonatal induction of tolerance to skeletal tissue allografts without immunosuppression. Plast Reconstr Surg 105:2424–2430
Petit F, Minns AB, Nazzal JA et al (2004) Prolongation of skin allograft survival after neonatal injection of donor bone marrow and epidermal cells. Plast Reconstr Surg 113:270–276
Siemionow M, Ozer K (2002) Advances in composite tissue allograft transplantation as related to the hand and upper extremity. J Hand Surg [Am] 27:565–580
Webber SA, Boyle GJ, Law YM et al (2003) A clinical trial of intrathymic inoculation of donor bone marrow with pediatric heart transplantation. Am J Transplant 3(S5):167
Guenther DA, Madsen JC (2005) Advances in strategies for inducing central tolerance in organ allograft recipients. Pediatr Transplant 9:277–281
Petit F, Lantieri L, Randolph MA, Lee WP (2006) Les voies de recherche en immunologie appliquées à l’allotransplantation de tissus composites. Ann Chir Plast Esth 51:11–17
Kirk AD (2003) Crossing the bridge: large animal models in translational transplantation research. Immunol Rev 196:176–196
Jain S, Lakhtakia PK (2002) Profile of congenital transverse deficiencies among cases of congenital orthopaedic anomalies. J Orthop Surg 10:45–52
Giraux P, Sirigu A, Schneider F, Dubernard JM (2001) Cortical reorganization in motor cortex after graft of both hands. Nat Neurosci 4:691–692
Brenneis C, Loscher WN, Egger KE et al (2005) Cortical motor activation patterns following hand transplantation and replantation. J Hand Surg [Br] 30:530–533
Farne A, Roy AC, Giraux P et al (2002) Face or hand, not both: perceptual correlates of reafferentation in a former amputee. Curr Biol 12:1342–1346
Mogilner A, Grossman JA, Ribary U et al (1993) Somatosensory cortical plasticity in adult humans revealed by magnetoencephalography. Proc Natl Acad Sci USA 90:3593–3597
Pearson J, Pytel BA (1981) Neuronal survival and peripheral tissue size during human embryogenesis: study of a partial twinning. Dev Neurosci 4:142–149
Wetts R, Vaughn JE (1998) Peripheral and central target requirements for survival of embryonic rat dorsal ganglion neurons in slice cultures. J Neurosci 18:6905–6913
Caldero J, Prevette D, Mei X et al (1998) Peripheral target regulation of the development and survival of spinal sensory and motor neurons in the chick embryo. J Neurosci 18:356–370
Stoeckel MC, Jörgens S, Witte OW, Seitz RJ (2005) Reduced somatosensory hand representation in thalidomide-induced dysmelia as revealed by fMRI. Eur J Neurosci 21:556–562
Stoeckel MC, Pollok B, Witte OW et al (2005) Shrinkage of somatosensory hand area in subjects with upper extremity dysmelia revealed by magnetoencephalography. J Neurophysiol 93:813–818
Melzack R (1998) Possible phantom pain for childhood extremity aplasia. Fortschr Neurol Psychiatr 66(1):6 [German]
Wilkins KL, McGrath PJ, Finley GA, Katz J (1998) Phantom limb sensations & phantom limb pain in child & adolescent amputees. Pain 78:7–12
Boonstra AM, Rijnders LJ, Groothoff JW, Eisma WH (2000) Children with congenital deficiencies or acquired amputations of the lower limbs: functional aspects. Prosthet Orthot Int 24:19–27
Price EH (2006) A critical review of congenital phantom limb cases & a developmental theory for the basis of body image. Conscious Cogn [In press]
Gilbert A (1982) Toe transfers for congenital hand defects. J Hand Surg [Am] 7:118–124
Lister G (1988) Microsurgical transfer of the second toe for congenital deficiency of the thumb. Plast Reconstr Surg 82:658–665
Eaton CJ, Lister GD (1991) Toe transfer for congenital hand defects. Microsurgery 12:186–195
Foucher G, Moss ALH (1991) Microvascular second toe to finger transfer: a statistical analysis of 55 transfers. Br J Plast Surg 44:87–90
Vilkki S (1995) Advances in microsurgical reconstruction of the congenitally adactylous hand. Clin Orthop 314:45–58
Van Holder C, Giele H, Gilbert A (1999) Double second toe transfer in congenital hand anomalies. J Hand Surg [Br] 24:471–475
Wei FC, Jain V, Chen SHT (2003) Toe-to-hand transplantation. Hand Clin 19:165–175
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Gazarian, A., Abrahamyan, D.O. (2007). Limb Transplantation in Congenital Deformities. In: Lanzetta, M., Dubernard, JM., Petruzzo, P. (eds) Hand Transplantation. Springer, Milano. https://doi.org/10.1007/978-88-470-0374-3_55
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DOI: https://doi.org/10.1007/978-88-470-0374-3_55
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